1,3-BENZODIOXOLE-4-CARBOXYLICACID

A solution of methyl benzo[ ][1 , 3]dioxole-4-carboxylate (0.4 g, 2.22 mmol) in methanol (8.0 mL) was treated with 2.0 M aqueous KOH (2.2 mL) and the solution stirred at rt for 3 hours. The mixture was concentrated to ~3 mL volume, diluted with water (5 mL) and acidified to pH ~3 using 2.0 M HCI. The resulting precipitate was removed by filtration, washed with water then diethyl ether and dried in vacuo to give benzo[ ][1 , 3]dioxole-4-carboxylic acid as a beige solid (0.38 g, 97percent).Compound P-2 (500 mg, 2.8 mmol) was weighed and suspended in 5 mL of water. Add 2N NaOH aqueous solution 10mL, Heat to 50°C for about 5 hours, The reaction solution is clear. Pour the reaction solution into ice water, Adjust pH to acidic with 2N dilute HCl There is a solid precipitated, Filtering, Dry powder 280mg, Yield 61percent. Used for the next reaction without purification.To a solution of the compound of the previous step (16 g) in methanol (170 ml) was added a solution of sodium hydroxide (9.9 g) in water (40 ml), and the mixture was stirred at room temperature for 3.5 hr. 2, 3-(methylenedioxy)benzoic acid A solution of methyl benzo[ ][1 , 3]dioxole-4-carboxylate (0.4 g, 2.22 mmol) in methanol (8.0 mL) was treated with 2.0 M aqueous KOH (2.2 mL) and the solution stirred at rt for 3 hours. The mixture was concentrated to ~3 mL volume, diluted with water (5 mL) and acidified to pH ~3 using 2.0 M HCI. The resulting precipitate was removed by filtration, washed with water then diethyl ether and dried in vacuo to give benzo[ ][1 , 3]dioxole-4-carboxylic acid as a beige solid (0.38 g, 97percent).Compound P-2 (500 mg, 2.8 mmol) was weighed and suspended in 5 mL of water. Add 2N NaOH aqueous solution 10mL, Heat to 50°C for about 5 hours, The reaction solution is clear. Pour the reaction solution into ice water, Adjust pH to acidic with 2N dilute HCl There is a solid precipitated, Filtering, Dry powder 280mg, Yield 61percent. Used for the next reaction without purification.To a solution of the compound of the previous step (16 g) in methanol (170 ml) was added a solution of sodium hydroxide (9.9 g) in water (40 ml), and the mixture was stirred at room temperature for 3.5 hr. 2, 3-(methylenedioxy)benzoic acid

Molecular Weight:166.13
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:166.02660867
Monoisotopic Mass:166.02660867
Topological Polar Surface Area:55.8
Heavy Atom Count:12
Complexity:192
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes