Benzyl acetate

150.174

150.17

205-399-7

0ECG3V79ZJ

1331

4550

1993

DTXSID0020151

WATER-WHITE LIQUID

2915390090

26.3

2

Colorless liquid with a pear smell

1.050 g/cm³ @ Temp: 25 °C

-51 °C

213 °C

216 °F

n20/D 1.502(lit.)

H2O: <0.1 g/100 mL at 23 ºC

Complete packaging, light loading and unloading, warehouse ventilation, away from the fire, high temperature, and oxidants stored separately

0.164mmHg at 25°C

5.1

vol% in air: 0.9.4

PEAR-LIKE ODOR

BITTER, PUNGENT TASTE

VAPOR PRESURE = 1.0 MM HG @ 45 °C

Insoluble in water.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

BENZYL ACETATE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. This chemical is incompatible with strong oxidizing agents. It is also incompatible with acids, bases and reducing agents. (NTP, 1992)

862 °F (NTP, 1992)|460 °C

Ⅲ

2810

1

R36/37/38

S26-S37/39

AF5075000

Xi

Separated from strong oxidants. Ventilation along the floor.

Stable under normal temperatures and pressures.

P210, P260, P261, P264, P270, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P307+P311, P312, P314, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, P501

H412

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Benzyl acetate is a food additive permitted for direct addition to food for human consumption, as long as 1) the quantity added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) when intended for use in or on food it is of appropriate food grade and is prepared and handled as a food ingredient. Synthetic flavoring substances and adjuvants incl benzyl acetate may be safely used in foods.

DHHS/NTP; Toxicology & Carcinogenesis Studies of Benzyl Acetate in F344/N Rats and B6C3F1 Mice (Gavage Studies) Technical Report Series No. 250 (1986) NIH Publication No. 86-2506|WHO/IPCS; Toxicological Evaluation of Certain Food Additives and Contaminants WHO Food Additives Series 32 (1993)

This chemical is combustible. (NTP, 1992)|Combustible. Above 90 °C explosive vapour/air mixtures may be formed.|Flammable - 2nd degree

H412 (91.98%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]|P273, and P501|Aggregated GHS information provided by 2175 companies from 15 notifications to the ECHA C&L Inventory.| |Danger|H227: Combustible liquid [Warning Flammable liquids]|P210, P260, P261, P264, P270, P271, P280, P302+P352, P304+P340, P305+P351+P338, P307+P311, P312, P314, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should protect this material from exposure to light. Keep it away from oxidizing materials and store it under refrigerated temperatures. (NTP, 1992)

Self-contained breathing apparatus, rubber boots and heavy rubber gloves. (USCG, 1999)

Combustible liquid.

Explosive limits , vol% in air: 0.9-8.4

ALCOHOL FOAM, CARBON DIOXIDE.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

... Irritating to skin, eyes, respiratory tract.

Ventilation. Cover the spilled material with earth or sand. Collect leaking and spilled liquid in covered containers as far as possible. Wash away remainder with plenty of water.

Separated from strong oxidants. Ventilation along the floor.

A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20 °C; on spraying or dispersing, however, much faster.

The vapour is irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause unconsciousness.

The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the kidneys.

NO open flames. Above 90 °C use a closed system and ventilation.

Use ventilation, local exhaust or breathing protection.

Protective gloves.

Wear safety spectacles.

| 1 - Materials that, under emergency conditions, can cause significant irritation.| 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.| 0 - Materials that in themselves are normally stable, even under fire conditions.| 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.

Benzyl acetate was detected in an aqueous industrial effluent extract collected between Nov 1979-81 in the organics and plastics industrial category at a concentration of 40 ng/ul extract(1).

Benzyl acetate was identified as a volatile component in 15 out of 31 consumer fragrance products, including perfume, shampoo, and fabric softener(1). Benzyl acetate was identified as a volatile component emitted from a sample of rubberized jute carpet cushion during chemical screening experiments(2). Benzyl acetate was identified as a volatile organic compound emitted by a household detergent(3). Benzyl acetate was identified as a volatile compound in two colognes, a perfume and a soap(4).

IDENTIFICATION: Benzyl acetate is a solvent used in perfumery and in chemical synthesis. HUMAN EXPOSURE: Benzyl acetate is absorbed from the gastrointestinal tract, through the lungs and through intact skin. It is hydrolyzed in man to benzyl alcohol and acetate; the benzyl radical is oxidized to benzoic acid and excreted as hippuric acid. ANIMAL/BACTERIAL STUDIES: This compound is hydrolyzed in vitro with a pancreatin preparation. Benzylmercapturic acid and hippuric acid were isolated from the urine of rats that had been injected sc with benzyl acetate. Mice and rats were dosed either iv or po with (14)C labeled benzyl acetate. Elimination of benzyl acetate as carbon dioxide or volatiles was minimal. The elimination of the (14)C label occurred mainly in urine with less than 1% excreted in the feces. More than 90% of the (14)C in urine was present as hippuric acid with minor amounts present as benzyl alcohol. Neither route of administration or dose had any significant effect on the pattern of elimination. Groups of 5 B6C3F1 mice of each sex were dosed with benzyl acetate in corn oil by gavage daily for 14 days. All male mice at the highest dose level had died by day 3 of the study. Weight changes were not dose related. At autopsy the only effect reported was a thickening of the mucosa of the stomach and in the cardiac region in two males and all females in the highest dose group and one female in the medium dose group. Groups of 50 male and female B6C3F1 mice were administered benzyl acetate in corn oil by gavage for 5 days/wk for 103 weeks. Vehicle control groups of 50 animals per sex were administered corn oil by gavage. The high mortality rate in female mice was associated with infection, resulting in inflammation or abcesses of the ovaries, uterus, mesentery, peritoneum or multiple organs. There was no association of treatment with the reported incidences of hepatocellular and forestomach tumors after the administration of benz yl acetate. Groups of 50 male and female F344/N rats of each sex were administered benzyl acetate in corn oil 5 days/wk for 103 weeks. Vehicle control groups consisted of 50 animals per sex were administered corn oil by gavage. The incidence of all malignant epithelial tumors in the preputial gland of male rats was elevated in the high dose group. There was increased incidence of retinopathy and cataracts in the high dose males and low dose females. In mutagenicity tests using Salmonella typhimurium TA100, TA1535, TA1537, TA98 with or without rat or hamster-9 activation results were negative. In vitro mammalian cytogenicity chromosomal aberrations in Chinese hamster ovary cells produced a negative response, in presence or absence of induced rat liver S-9 fraction. In the mouse lymphoma cell assay, it was positive for mutagenicity when induced by metabolic activation and negative in the absence of activation. Bacterial gene mutation with Bacillus subtilus and unscheduled DNA synthesis in vitro and in vivo were both negative.[

Rat (Osborne-Mendel) oral 2.49 g/kg

Benzyl acetate />99% pure was administered/ in corn oil by gavage to groups of 50 male 50 female F344/N rats at doses of 0, 250, or 500 mg/kg body weight and to groups of 50 male and 50 female B6C3F1 mice at doses of 0, 500, or 1000 mg/kg once daily five of days per week for 103 weeks. ... Under the conditions of these gavage studies, benzyl acetate incr the incidence of acinar cell adenomas of the exocrine pancreas in male F344/N rats; the gavage vehicle may have been a contributing factor. There was no evidence of carcinogenicity for female F344/N rats. For male and female B6C3F1 mice there was some evidence of carcinogenicity in that benzyl acetate caused an incr incidences of hepatocellular adenomas and squamous cell neoplasms of the forestomach.

PRESENT AS MAIN CONSTITUENT IN SEVERAL OILS & FLOWER ABSOLUTES: YLANG-YLANG, CANANGA, NEROLI, JASMINE, HYACINTH, GARDENIA, TUBEROSE. IT HAS BEEN ISOLATED FROM FLOWERS OF ... /AZALEA/ ... CAN BE ISOLATED FROM NATURAL SOURCES (IN WHICH IT MAY OCCUR AT LEVELS UP TO 65%).|Benzyl acetate occurs in a number of plants, particularly jasmine(1). Benzyl acetate was identified as a volatile component of roasted filberts(2) and in the juice of Japanese Kogyoku apples(3).

Benzyl acetate's production and use in artificial jasmine and other perfumes; in soap perfume; as a flavoring; a solvent and high boiler for cellulose acetate and nitrate, natural and synthetic resins; in oils; lacquers; polishes; printing inks; and in varnish removers(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 280(SRC), determined from a log Kow of 1.96(2) and a regression-derived equation(3), indicates that benzyl acetate is expected to have moderate mobility in soil(SRC). Volatilization of benzyl acetate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.1X10-5 atm-cu m/mole(SRC) derived from its experimental values for vapor pressure, 0.18 mm Hg(4), and water solubility, 3.1X10+3 mg/l(5). Biodegradation of benzyl acetate in soil may be important(SRC), based upon its biodegradation in water(5).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 280(SRC), determined from a log Kow of 1.96(2) and a regression-derived equation(3), indicates some adsorption of benzyl acetate to suspended solids and sediment in the water column is expected(SRC). Benzyl acetate is expected to volatilize from water surfaces(3,SRC) based on an estimated Henry's Law constant of 1.1X10-5 atm-cu m/mole(SRC) from its experimental values for vapor pressure, 0.18 mm Hg(4), and water solubility, 3.1X10+3 mg/l(5). Estimated volatilization half-lives for a model river and model lake are 4.1 and 34 days, respectively(3,SRC). According to a classification scheme(6), an estimated BCF of 18(3,SRC), from a log Kow(2), suggests that bioconcentration in aquatic organisms is low(SRC). Benzyl acetate is expected to biodegrade in aquatic systems(SRC); benzyl acetate reached 92 to 96% of its theoretical BOD over a period of 4 weeks(5). An estimated hydrolysis half-life of 38 days at pH 7(7), indicates hydrolysis may be an important process(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), benzyl acetate, which has a vapor pressure of 0.18 mm Hg at 25 °C(2,SRC), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase benzyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 2.5 days(3,SRC).

The rate constant for the vapor-phase reaction of benzyl acetate with photochemically-produced hydroxyl radicals has been estimated as 6.4X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 2.5 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). A hydrolysis half-life of 38 days at 25 °C and pH 7 was calculated for benzyl acetate from an estimated pseudo-first-order hydrolysis rate constant of 2.1X10-7/s(2). The UV spectrum of benzyl acetate in methanol indicates no absorption above 290 nm, suggesting this compound is not expected to directly photolyze(3). Photolysis of benzyl acetate in t-butanol with 1.3 mol/l acetone added as a sensitizer at 300 nm produced (quantum yields) t-butyl benzyl ether (<0.01) and bibenzyl (<0.01)(4). The rate constant for the reaction of benzyl acetate with peroxy radicals in water at 30 °C was determined to be 2.3 L/mol s(5). This value corresponds to an estimated half-life of 9.6 years(SRC) at an aqueous peroxy radical concentration of 1X10-9 mol/l(6).

An estimated BCF of 18 was calculated for benzyl acetate(SRC), using a log Kow of 1.96(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests that bioconcentration in aquatic organisms is low(SRC).

The Koc of benzyl acetate is estimated as approximately 180(SRC), using a log Kow of 1.96(1) and a regression-derived equation(2,SRC). According to a classification scheme(3), this estimated Koc value suggests that benzyl acetate is expected to have moderate mobility in soil(SRC).

The Henry's Law constant for benzyl acetate is estimated as 1.1X10-5 atm-cu m/mole(SRC) from its experimental values for vapor pressure, 0.18 mm Hg(1), and water solubility, 3.1X10+3 mg/l(2). This value indicates that benzyl acetate is expected to volatilize from water surfaces(3,SRC). Based on this Henry's Law constant, the estimated volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 4.1 days(3,SRC). The estimated volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 34 days(3,SRC). Benzyl acetate's Henry's Law constant(1,2,SRC) indicates that volatilization from moist soil surfaces may be important(SRC).

Benzyl acetate was identified as a volatile component of roasted filberts(1). Benzyl acetate was identified as a volatile flavor compound in the juice of Japanese Kogyoku apples(2).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 128,306 workers (52,480 of these are female) are potentially exposed to benzyl acetate in the US(1). Occupational exposure to benzyl acetate may occur through inhalation and dermal contact with this compound at workplaces where benzyl acetate is produced or used(SRC). The general population may be exposed to benzyl acetate via ingestion of food, and inhalation and dermal contact with consumer products containing benzyl acetate(SRC).

Benzyl acetate was absorbed from the gastrointestinal tract of rats and mice, with approximately 90% of the administered dose recovered as various metabolites in the urine within 24 hr. ... This capacity for absorption, metabolism, and disposition was unaffected by the amount or number of doses administered.|The effect of vehicle and occlusion on the in vitro percutaneous absorption of [methylene-14C]-benzyl acetate (1.7-16.6 mg/sq cm) has been studied in diffusion cells using full thickness skin from male Fischer 344 rats. Absorption of neat benzyl acetate through rat skin occluded with parafilm was 49.3 +/- 2.0% (mean +/- SD, n=4) after 48 hr. When benzyl acetate in ethanol was applied to the skin and the skin was occluded with parafilm, the extent of absorption at 48 hr was not significantly different from that after neat application. However at 6 hr, as the ethanol content of the application mixture was increased, the absorption of benzyl acetate through occluded skin was enhanced proportionally. When phenylethanol was used as a vehicle, the extent of the benzyl acetate absorption through occluded skin at 48 hr was enhanced (P less than 0.05) compared with that after application neat; with 50% (v/v) phenyl-ethanol, absorption at 48 hr was 56.3 +/- 4.9%. However, this enhanced absorption did not correlate with the proportion of phenylethanol in the application mixture. When dimethylsulphoxide was used as a vehicle, the extent of absorption of benzyl acetate through occluded skin at 48 hr was enhanced (P less than 0.05) compared with that after application neat (absorption was 59.3 +/- 3.7% of the applied dose when 50% (v/v) dimethylsulphoxide was used). As the dimethylsulphoxide content of the application mixture was increased, the absorption of benzyl acetate was enhanced proportionally. Occlusion of the skin surface with parafilm often significantly enhanced absorption (P less than 0.05), although the effect varied with time and vehicle. In general, the degree of any enhanced absorption caused by the use of a vehicle or occlusion of the skin was small, and, in most cases, would be unlikely to be toxicologically significant.|The comparative absorption of ... benzyl acetate has been studied in rat and human skin, using shaved, full-thickness dorsal skin of male Fischer 344 rats and full-thickness human skin obtained from patients undergoing surgical resection. Penetration of the compound through rat and human skin was evaluated in vitro in flow-through diffusion cells following topical application of neat [methylene-14C] benzyl acetate (33.1 mg/sq cm) to the epidermal surface and occlusion with a teflon cap, 2.9 cm above the skin surface. The absorption of benzyl acetate across rat skin was rapid and extensive, reaching 34.3 +/- 3.9% of the applied dose (11.3 +/- 1.3 mg/sq cm) (mean +/-SD, n=12) at 24 hr and 55.8 +/- 5.0% of the applied dose (18.5 +/- 1.7 mg/sq cm)at 72 hr. The penetration of benzyl acetate was significantly (P<0.05) less rapid and extensive through human skin, reaching 5.5 +/- 0.1% of the applied dose (1.8 +/- 0.0 mg/sq cm) (mean +/- SD, n=12) at 24 hr and 17.8 +/- 3.3% of the applied dose (5.9 +/-1.1 mg sq cm) at 72 hr. The rate of penetration of benzyl acetate was greater through rat skin than through human tissue at all time points studied up to 72 hr. The maximum rate of skin penetration was 0.6 +/- mg/sq cm/hr and 0.1 +/_- 0.0 mg/sq cm/hr through rat and human skin, respectively. These data indicate that systemic exposure to benzyl acetate may occur after skin contact in humans. They also support the evidence from the literature that human skin is generally less permeable to xenobiotics than rat skin.

... BENZYL ACETATE IS RAPIDLY HYDROLYZED TO ACETIC ACID AND BENZYL ALCOHOL, AND THE LATTER OXIDIZED TO BENZOIC ACID & ... EXCRETED AS HIPPURIC ACID.|In rats, benzyl acetate is hydrolyzed to benzyl alcohol, which is oxidized to benzoic acid and excreted as hippuric acid and benzyl mercapturic acid.|In a chemical disposition study conducted by the NTP, male Fischer 344 rats and male B6C3F1 mice were shown to efficiently absorb and rapidly metabolize and excrete orally administered benzyl acetate. The doses used in this study were 5, 50, or 500 mg/kg for rats and 10, 100, or 1000 mg/kg for mice in single dose corn oil gavage administrations and 500 mg/kg for rats and 1000 mg/kg for mice daily five times per week for two weeks, also administered by gavage in corn oil. Most (90%) of the benzyl acetate-derived radioactivity was recovered in the urine and none was detected in the liver, blood, muscle, adipose tissue skin, lung, kidney, or stomach of treated rats or mice. The major metabolite isolated in the urine was hippuric acid (94%-99% of the dose). Other metabolites found were mercapturic acid and benzyl alcohol. Benzyl acetate was not detected in the urine of treated animals. Neither the size of the dose nor the frequency of dosing had any effect on the absorption, metabolism, or excretion of this compound. There was no evidence to indicate any saturation of this metabolizing capacity in either species over the range of doses studied.|Effects of gavage versus dosed feed administration on the toxicokinetics of benzyl acetate were studied in male F344 rats and B6C3F1 mice. Benzyl acetate was rapidly hydrolyzed to benzyl alcohol and then oxidized to benzoic acid. After gavage administration of benzyl acetate in corn oil at 500 mg/kg (rats) and 1000 mg/kg(mice), high benzoic acid plasma concentrations were observed. In contrast, much lower benzoic acid plasma concentrations were found after dosed feed administration at about 615 mg/kg/day for rats and about 850 mg/kg/day for mice. Results show that although the daily doses of benzyl acetate are comparable, bolus gavage administration effectively saturated the benzoic acid elimination pathway whereas dosed feed administration did not. In contrast, hippuric acid plasma concentrations were similar after both gavage and dosed feed administration due to the depletion of the glycine supply pool. ...

Harmful if inhaled. May be harmful if swallowed or absorbed through the skin. Vapor or mist is irritating to the eyes, mucous membrane and upper respiratory tract. (USCG, 1999)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

IF INGESTED CAN CAUSE GI IRRITATION WITH VOMITING & DIARRHEA.|... BENZYL ACETATES ... ARE OF LOW VOLATILITY ... & EXCEPT FOR LOCAL IRRITATION, NO EFFECTS HAVE BEEN REPORTED IN MAN.|SUMMARY TOXICITY STATEMENT: ACUTE= HIGH VIA INHALATION ROUTE. HIGH= CAPABLE OF CAUSING DEATH OR PERMANENT INJURY DUE TO EXPOSURES OF NORMAL USE; INCAPACITATING & POISONOUS; REQUIRES SPECIAL HANDLING.|SUMMARY TOXICITY STATEMENT; ACUTE= MODERATE VIA ORAL ROUTE. AN IRRITANT. MODERATE= MAY CAUSE REVERSIBLE OR IRREVERSIBLE CHANGES TO EXPOSED TISSUE, NOT PERMANENT INJURY OR DEATH; CAN CAUSE CONSIDERABLE DISCOMFORT.|Benzyl acetate produces respiratory tract irritation and /CNS depressant/ effects in humans, and continued exposure to benzyl acetate at an ambient concentration of 50 ppm results in kidney damage. When ingested, benzyl acetate can cause general intestinal irritation.

(14C)benzyl acetate

The substance can be absorbed into the body by inhalation and by ingestion.

Burning sensation. Confusion. Dizziness. Drowsiness. Laboured breathing. Sore throat.

Dry skin.

Redness.

The bulk of benzyl acetate is used in soap odors, but it is also popular for other perfumes and is used to a minor extent in flavors (1980).

FREE FROM CHLORINE GRADE WHICH SHOULD HAVE ESTER CONTENT OF 97% BUT FOR WHICH LOWER GRADE MATERIAL IS SOMETIMES SUBSTITUTED; TECHNICAL GRADE WHICH IS NOT FREE FROM CHLORINE & FOR WHICH ESTER CONTENT VARIES CONSIDERABLY; "FOOD CHEMICALS CODEX".

All other chemical product and preparation manufacturing|Acetic acid, phenylmethyl ester: ACTIVE|FEMA NUMBER 2135. NON-ALCOHOLIC BEVERAGES, 7.8 PPM; ICE CREAM, ICES ... 14 PPM; CANDY, 34 PPM; BAKED GOODS, 22 PPM; GELATINS & PUDDINGS, 23 PPM; CHEWING GUM, 760 PPM.

GC with FID or MS has been used to analyze for benzyl acetate in volatile mixtures.

Combined GC/MS has been used to detect benzyl acetate at trace levels in mouse urine.

Food additives -> Flavoring Agents|Flavoring Agents -> JECFA Flavorings Index|Fire Hazards -> Flammable - 2nd degree|Cosmetics -> Solvent

Flavoring Agents