2-Hydroxycyclohexanecarboxylic acid

2-hydroxycyclohexanecarboxylic acid is a hydroxy monocarboxylic acid. It derives from a cyclohexanecarboxylic acid.

In the first step, 9.8 kg (100 mol) of epoxycyclohexane was dissolved in 50 L of NMP.2.88 kg (120 mol) of Mg powder was added under stirring, and the temperature was lowered to -15 ° C to -5 ° C.19.5 kg (180 mol) of TMSCl was added while introducing carbon dioxide gas into the solution.After 10 hours of reaction, After the reaction is completed, the temperature is below 0 °C.The filtrate was added to a 1N hydrochloric acid solution.Adjust pH=3-4, extract ethyl acetate 80L twice, After washing with a half-saturated saline solution, the organic layer was distilled to obtain 13.8 kg (95.8 mol) of 2-hydroxycyclohexanecarboxylic acid.The yield is 95.8percent, and the ratio of cis is inversely 2.3:7.7;

Molecular Weight:144.17
XLogP3:1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:144.078644241
Monoisotopic Mass:144.078644241
Topological Polar Surface Area:57.5
Heavy Atom Count:10
Complexity:133
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes