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2-Chloro-4-methylaniline

2-Chloro-4-methylaniline structure

CAS No:
615-65-6
Formula:
C7H8ClN
Chemical Name:
2-Chloro-4-methylaniline
Synonyms:
Benzenamine,2-chloro-4-methyl-;p-Toluidine,2-chloro-;2-Chloro-4-methylbenzenamine;2-Chloro-p-toluidine;2-Chloro-4-methylaniline;3-Chloro-4-aminotoluene;4-Methyl-2-chloroaniline;4-Amino-3-chlorotoluene;1-Amino-2-chloro-4-methylbenzene;(2-Chloro-4-methylphenyl)amine;NSC 60120
Categories:
Organic Chemistry > Amides

Description

clear yellow to pale brown liquid The chloromethylanilines are colorless or white crystalline solids or liquids, some have a mild fishy odor.

2-Chloro-4-methylaniline Basic Attributes

Molecular Weight：

141.6

Exact Mass：

141.60

EC Number：

210-440-7

UNII：

K59ISJ2KO1

NSC Number：

60120

DSSTox ID：

DTXSID3022083

HScode：

2921430090

Characteristics

PSA：

XLogP3：

1.9

Appearance：

clear yellow to pale brown liquid

Density：

1.151 g/cm³ @ Temp: 20 °C

Melting Point：

7 °C

Boiling Point：

219 °C @ Press: 732 Torr

Flash Point：

99.4±0.0 °C

Refractive Index：

1.585

Water Solubility：

SLIGHTLY SOL IN WATER, ACETONE

Safety Information

Packing level：

III

Hazard category：

6.1

Transport codes：

UN 3429 6.1/PG 3

wgk germany：

hazard class code：

R22;R36/37/38

safety instructions：

S36/37-S37/39-S26

RTECS Number：

XU5110000

Marks：

Xn:Harmful;

Precautionary statement(s)：

P273-P280-P305 + P351 + P338

Hazard Statements：

H302 + H312 + H332-H315-H318-H412

GHS Classification：

|Danger|H302+H312+H332 (86.36%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]|P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, and P501|Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Non-Human Toxicity Values：

MUTATION/METABOLIC ACTIVATION SALMONELLA TYPHIMURIUM MUTATION DOSE 1 UMOL/PLATE

Drug Information

Metabolism/Metabolites：

FORMS 2,2'-DICHLORO-4,4'-DIMETHYLAZOBENZENE IN HORSERADISH. KNOWLES ET AL, J ECOL ENT 62: 411 (1969). /FROM TABLE/

Human Toxicity Excerpts：

THE TOLUIDINES (BOTH O- AND P-) MAY PRODUCE TRANSIENT HEMATURIA AS WELL AS METHEMOGLOBINEMIA AFTER HEAVY EXPOSURES, BUT CHLORO-DERIVATIVES ARE MORE POTENT IN THIS RESPECT, ESPECIALLY 5-CHLORO-O-TOLUIDINE... /TOLUIDINES/|THE CYSTITIS RELATED TO THESE ANILINE DERIVATIVES HAS NO RELATIONSHIP TO CARCINOGENIC AMINE-RELATED PROCESSES. /CHLOROTOLUIDINES/|...HEMATURIA MAY BE OBSERVED IN MEN HANDLING CHLOROTOLUIDINES. ...MAY BE A HEMORRHAGIC CYSTITIS WITH PAINFUL & FREQUENT MICTURITION. THIS ACUTE PROBLEM... NO LONG TERM SIGNIFICANCE & CLEARS...ON CESSATION... IF...PERSISTS, OTHER PATHOLOGICAL URINARY TRACE PHENOMENA MUST BE CONSIDERED. /CHLOROTOLUIDINES/

MeSH Entry Terms：

2-chloro-4-toluidine

2-Chloro-4-methylaniline Use and Manufacturing

Uses

INTERMEDIATE

Manufacturing Info：

Benzenamine, 2-chloro-4-methyl-: ACTIVE

Computed Properties

Molecular Weight:141.60
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:141.0345270
Monoisotopic Mass:141.0345270
Topological Polar Surface Area:26
Heavy Atom Count:9
Complexity:94.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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2-Chloro-4-methylaniline

CAS No.: 615-65-6

Content: 99.00%

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