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Chlorohydroquinone

Chlorohydroquinone structure

CAS No:
615-67-8
Formula:
C6H5ClO2
Chemical Name:
Chlorohydroquinone
Synonyms:
1,4-Benzenediol,2-chloro-;Hydroquinone,chloro-;2-Chloro-1,4-benzenediol;Chlorohydroquinone;1,4-Dihydroxy-2-chlorobenzene;Chloroquinol;Monochlorohydroquinone;2-Chlorohydroquinone;2-Chloro-1,4-dihydroxybenzene;1-Chloro-2,5-dihydroxybenzene;Chloro-p-hydroquinone;2-Chloro-1,4-hydroquinone;NSC 427;NSC 5934;134900-92-8;140627-31-2;68103-34-4
Categories:
Active Pharmaceutical Ingredients > Other Chemical Drugs

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Description

LIGHT BROWN TO GREY FINE CRYSTALLINE POWDER

Chlorohydroquinone Basic Attributes

Molecular Weight：

144.554

Exact Mass：

144.56

EC Number：

210-442-8

UNII：

93SNN9E337

NSC Number：

5934|427

DSSTox ID：

DTXSID4060656

Color/Form：

WHITE TO LIGHT-TAN FINE CRYSTALS

HScode：

29081990

Characteristics

PSA：

40.5

XLogP3：

1.4

Appearance：

White to off-white crystals

Density：

1.5±0.1 g/cm3

Melting Point：

100 °C

Boiling Point：

263 °C

Flash Point：

119.7±21.8 °C

Refractive Index：

1.629

Water Solubility：

H2O: soluble ;VERY SOL IN WATER AND ALC, SLIGHTLY SOL IN ETHER

Storage Conditions：

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Safety Information

Packing level：

Ⅲ

Hazard category：

6.1

Transport codes：

2811

wgk germany：

hazard class code：

6.1

safety instructions：

S36/37-S37/39-S26

RTECS Number：

MX4800000

Marks：

Xi:Irritant;

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P280-P305 + P351 + P338 + P310

Hazard Statements：

H315-H317-H318-H335

Disposal Methods：

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

GHS Classification：

|Danger|H302 (18.75%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P333+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 48 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Metabolism/Metabolites：

YIELDS 3-CHLORO-4-HYDROXYPHENYL-BETA-D-GLUCURONIDE IN RABBIT. /FROM TABLE/

Human Toxicity Excerpts：

IRRITATING BUT NOT CORROSIVE. HUMAN POISONINGS HAVE BEEN REPORTED FROM MIXTURE OF HYDROQUINONE & METOL. SYSTEMIC ACTIONS LIKE PHENOL, BUT IN ADDITION TREMORS & CONVULSIONS ARE PROMINENT, PLUS AN OCCASIONAL SEVERE HEMOLYTIC ANEMIA (SUBSEQUENT TO METHEMOGLOBINEMIA?). /HYDROQUINONE/|INGESTION OF 1 G /HYDROQUINONE/ HAS CAUSED TINNITUS, NAUSEA, VOMITING, SENSE OF SUFFOCATION, SHORTNESS OF BREATH, CYANOSIS, CONVULSIONS, DELIRIUM, COLLAPSE. DEATH HAS FOLLOWED INGESTION OF 5 G. IRRITATION OF GI TRACT OCCURS WITH ORAL INGESTION. /HYDROQUINONE/|DERMATITIS CAN RESULT FROM SKIN CONTACT. STAINING AND OPACIFICATION OF CORNEA OCCUR IN WORKERS EXPOSED FOR PROLONGED PERIODS TO CONCN OF VAPOR... /HYDROQUINONE/|NO TOXICITY DATA WERE LOCATED. /IT IS/ PRESUMABLY SIMILAR IN TOXICITY TO HYDROQUINONE.|For more Human Toxicity Excerpts (Complete) data for CHLOROHYDROQUINONE (6 total), please visit the HSDB record page.

MeSH Entry Terms：

2-chloro-1,4-hydroxyquinone

Chlorohydroquinone Use and Manufacturing

Methods of Manufacturing

Chlorination of hydroquinone.

Uses

Chlorohydroquinone is a benzenediol that consists of hydroquinone bearing a single chloro substituent. It has a role as a metabolite. It is a member of monochlorobenzenes and a member of chlorohydroquinones.
Chlorohydroquinone is a component of polyethers based on organotin with potential application to breast cancer treatment via growth inhibition. Also a component in the synthesis of contraceptive agents in pharmaceutical compounds.
Chlorohydroquinone is used in photographic developing solutions. It is also a bactericide.

Formulations：

EDWAL LIQUID CHQ- CHLOROHYDROQUINONE, 10% SOLN.|GRADES: PHOTOGRAPHIC; COMMERCIAL.

Manufacturing Info：

1,4-Benzenediol, 2-chloro-: INACTIVE|TP - indicates a substance that is the subject of a proposed TSCA section 4 test rule.

Computed Properties

Molecular Weight:144.55
XLogP3:1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Exact Mass:143.9978071
Monoisotopic Mass:143.9978071
Topological Polar Surface Area:40.5
Heavy Atom Count:9
Complexity:97.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 615-67-8

Grade: Industrial Grade

Content: 99%

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