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Lipoic acid

Lipoic acid structure

CAS No:
62-46-4
Formula:
C8H14O2S2
Chemical Name:
Lipoic acid
Synonyms:
Thioctic;5-(dithiolan-3-yl)pentanoic acid;R-LIPOIC ACID POTASSIUM COMPOUND;6,8-Thioctic acid;6,8-Thiocticacid;6,8-Thiotic acid;6,8-Thioticacid;6-Thioctic acid
Categories:
Active Pharmaceutical Ingredients > Digestive System Drugs

Description

Thioctic acid, 6,8-dithiooctanoic acid

Lipoic acid is a class of compounds belonging to the B class vitamins and is the growth factor of yeast and some kinds of microorganisms. It can play the role of coenzyme role in a multi-enzyme system that is responsible for catalyzing the acyl transfer effect in the reaction of oxidative decarboxylation of pyruvate into acetate and oxidative decarboxylation reaction of α-ketoglutarate into succinic acid.

Its chemical name is 5-[3-(1,2-dithiol hetero-cycle)] pentanoic acid. The appearance is pale yellow crystals with the molecular weight being 206.33. DL-body: the melting point is 60~61 ℃. L-body (natural products): the melting point is 45~47.5 ℃. Optical rotation [α] D23 + 113 ℃. D-body (natural products): the melting point is 46~48 ℃. Optical rotation [α] D23 + 104 ℃. It is soluble in organic solvents but insoluble in water. It can be used for the prevention and treatment of acute hepatitis, liver cirrhosis, hepatic coma, fatty liver and other diseases.

Alpha lipoic acid (ALA) is synthesised enzymatically in the mitochondria from octanoic acid and plays a critical role in mitochondrial energy metabolism. ALA presents as two enantiomers: the R-(+) enantiomer, which is widely present in nature and is biologically active, and the S-(-) enantiomer, which is often included in synthetic-based ALA supplements but is believed to have limited biological activity.Formulations includes:R-alpha lipoic acid capsules, tablets, powders or dropsRacemic mixture of R- and S- alpha lipoic acid enantiomers in capsules, tablets, powders or dropsIntravenous administration of R-alpha lipoic acid

Alpha Lipoic Acid (ALA) was discovered in 1951. It is a sulfur-containing coenzyme, and when it was first isolated and studied, its main function was thought to be in the Krebs Cycle.In 1988, ALA was discovered to be a potent antioxidant, and is active in both fat- and watersoluble regions of the cell.

Lipoic acid Basic Attributes

Molecular Weight：

206.33

Exact Mass：

206.33

EC Number：

200-534-6

HScode：

2934999090

Characteristics

PSA：

87.90000

XLogP3：

2.16

Density：

1.2888 (rough estimate)

Melting Point：

48-52 °C(lit.)

Boiling Point：

315.2°C (rough estimate)

Flash Point：

>230 °F

Refractive Index：

1.5200 (estimate)

Water Solubility：

Soluble in methanol, ethanol, diethyl ether and chloroform

Vapor Pressure：

9.49X10-1 mm Hg at 25 °C (est)

Critical Temperature & Pressure：

4°C, protect from light

Safety Information

wgk germany：

hazard class code：

R22

safety instructions：

S24/25

Marks：

Xn:Harmful

Lipoic acid Use and Manufacturing

B vitamins, used in the treatment of acute and chronic hepatitis, cirrhosis, hepatic coma, fatty liver, diabetes, etc.; used in acute and chronic hepatitis, cirrhosis, hepatic coma, etc.; antioxidant; a kind of mitochondria Coenzyme, which acts as a coenzyme in a multi-enzyme system, catalyzes the oxidative decarboxylation of pyruvate to acetic acid and the oxidative decarboxylation of α-ketoglutarate to succinate.

Alpha-lipoic acid is a kind of B vitamins and can be used for the treatment of acute and chronic hepatitis, cirrhosis, hepatic coma, fatty liver, diabetes, etc. other uses of lipoic acid are as follows:1. Neutralize free radicals.2. It is quickly absorbed and utilized by body cells.3. Can strengthen the role of other antioxidants.4. Can be concentrated on the inside and outside of cells and cell membranes.5. Promote normal gene expression.6. Chelate metal ions, or excrete toxic metals from the body.7. Alpha-lipoic acid is an antioxidant that is made naturally in the body and also found in foods.

α-lipoic acid (ALA, thioctic acid) is an organosulfur component produced from plants, animals, and humans. It has various properties, among them great antioxidant potential and is widely used as a racemic drug for diabetic polyneuropathy-associated pain and paresthesia. It has been used in alternative medicine as a possibly effective aid in weight loss, treating diabetic nerve pain, healing wounds, lowering blood sugar, improving skin discoloration caused by vitiligo, and decreasing complications of coronary artery bypass graft (CABG) surgery.Alpha Lipoic Acid 600 mg | 45 Tablets

Drug Function and Efficacy

It can reduce lipid oxidation in nerve tissue; it may prevent the glycosylation of proteins; it inhibits aldose reductase, prevents the conversion of glucose or galactose into sorbitol, prevents diabetes, controls blood sugar and prevents neuropathy caused by hyperglycemia; it is a strong antioxidant in both water-soluble and oil-soluble matrices; it can directly or indirectly promote the regeneration of vitamin C and vitamin E in the body; it can increase the levels of glutathione and coenzyme Q10 in cells; it can chelate certain metal ions (such as copper, manganese, zinc) to form stable chelates; it protects against arsenic poisoning and can reduce liver toxicity after chromium poisoning; it chelates mercury ions in kidney slices.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Lipoic Acid Injection
Ingredients	Lipoic Acid
Indication	This product may inhibit the efficacy of cisplatin.
Specifications	12ml:0.3g
Manufacturer	Nanjing Xinbai Pharmaceutical Co., Ltd.

Lipoic Acid for Injection
Ingredients	Lipoic acid. Chemical name: (plusmn;)-5-[3-(1,2-dithiolane)]-pentanoic acid.
Indication	This product may inhibit the efficacy of sirtuin.
Specifications	0.15g
Manufacturer	Fuan Pharmaceutical Group Yantai Justaware Pharmaceutical Co., Ltd.

Lipoic Acid Tablets
Specifications	0.1 g

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Registered Holders

Jiangsu Shenlong Pharmaceutical Co., Ltd.

China
Active
Guang'an Kingday Pharma & Chem Co., Ltd.

China
Active
Suzhou Fushilai Pharmaceutical Co., Ltd.

China
Active

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