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Tetramethylurea

Tetramethylurea structure

CAS No:
632-22-4
Formula:
C5H12N2O
Chemical Name:
Tetramethylurea
Synonyms:
Urea,N,N,N′,N′-tetramethyl-;Urea,tetramethyl-;Urea,1,1,3,3-tetramethyl-;N,N,N′,N′-Tetramethylurea;Tetramethylurea;Temur;TMU;Tetramethylcarbamide;NSC 91488
Categories:
Chemical Reagents > Organic Reagents

Description

Clear colorless to pale yellow liquid

1,1,3,3-tetramethylurea is a member of the class of ureas that is urea substituted by methyl groups at positions 1, 1, 3 and 3 respectively. Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Tetramethylurea Basic Attributes

Molecular Weight：

116.16

Exact Mass：

116.16

BRN：

773898

EC Number：

211-173-9

UNII：

2O1EJ64031

NSC Number：

91488

DSSTox ID：

DTXSID1060893

Color/Form：

LIQUID

HScode：

29241900

Characteristics

PSA：

23.6

XLogP3：

0.2

Appearance：

Clear colorless to pale yellow Liquid

Density：

0.9687 g/cm³ @ Temp: 20 °C

Melting Point：

-1.2 °C

Boiling Point：

176.5 °C

Flash Point：

150 °F

Refractive Index：

1.4496-1.4516

Water Solubility：

Micible with water.

Storage Conditions：

Store below +30°C.

Vapor Pressure：

vaopr pressure = 13.9 mm Hg @ 71 deg C

Toxicity：

Oral-Mouse LD50: 2920 mg/kg

Flammability characteristics：

Combustible in case of open flame, high temperature and strong oxidant; emit toxic nitrogen oxide fumes during combustion

Odor：

FAINT, PLEASANT

Dissociation Constants：

PKB: 2

Experimental Properties：

DIPOLE MOMENT: 3.47 D IN BENZENE

Safety Information

Transport codes：

NA 1993 / PGIII

wgk germany：

hazard class code：

22-61

safety instructions：

53-45

RTECS Number：

YU2625000

Marks：

Xn,T

Storage features：

Completely packed, lightly placed; storeroom ventilated, away from open flames, high temperature, and stored separately from oxidants

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P201, P202, P210, P280, P281, P308+P313, P370+P378, P403+P235, P405, P501

Hazard Statements：

H227

Special Reports：

REVIEW OF PREPN, MFR, PROPERTIES AND USE AS SOLVENT AND AS REAGENT: LUTTRINGHAUS, DIRKSEN, AGNEW CHEM INT ED 3, 260 (1964).[The Merck Index. 9th ed. Rahway, New Jersey: Merck & Co., Inc., 1976., p. 1190]

GHS Classification：

|Danger|H302 (97.87%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, and P501|Aggregated GHS information provided by 141 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H227: Combustible liquid [Warning Flammable liquids]|P201, P202, P210, P280, P281, P308+P313, P370+P378, P403+P235, P405, and P501

Fire Potential：

FIRE HAZARD: MODERATE, VIA HEAT, FLAME & OXIDIZERS.

Fire Fighting Procedures：

FOAM, MIST, SPRAY, DRY CHEMICALS.

Toxicity

Toxicity class：

moderately toxic

Interactions：

MIXING TETRAMETHYLUREA WITH MINERAL OIL INCREASED MATERNAL TMU TOXICITY WHEN APPLIED TO SKIN OF RATS.|TETRAMETHYL UREA WAS CAPABLE OF ENHANCING THE TOXICITY OF MORPHINE AND CHLORPROMAZINE IN DOGS, MONKEYS, AND MICE.|TETRAMETHYLUREA LOWERED YIELDS AND/OR INCIDENCES OF TUMORS PROMOTED BY RETINYL ACETATE OR CROTON OIL AFTER INITIATION BY 7,12-DIMETHYLBENZ(A)ANTHRACENE. TOPICAL APPLICATION OF INDUCERS MIGHT HAVE THERAPEUTIC POTENTIAL IN EPIDERMAL CARCINOMA.

Drug Information

MeSH Entry Terms：

1,1,3,3-tetramethylurea

Tetramethylurea Use and Manufacturing

Methods of Manufacturing

PREPN: LAWSON, CROOM, J ORG CHEM, 28, 232 (1963).

Uses

As solvent and reagent.

Production

(1972) PROBABLY GREATER THAN 4.54X10+5 GRAMS|(1975) PROBABLY LESS THAN 4.54X10+5 GRAMS

Manufacturing Info：

Urea, N,N,N',N'-tetramethyl-: ACTIVE

Computed Properties

Molecular Weight:116.16
XLogP3:0.2
Hydrogen Bond Acceptor Count:1
Exact Mass:116.094963011
Monoisotopic Mass:116.094963011
Topological Polar Surface Area:23.6
Heavy Atom Count:8
Complexity:78.4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Content: 99%

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