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Home > Encyclopedia > Nandrolone phenylpropionate

Nandrolone phenylpropionate

pharmaceutical raw materials
Nandrolone phenylpropionate structure

Nandrolone phenylpropionate 

structure
  • CAS No:

    62-90-8

  • Formula:

    C27H34O3

  • Chemical Name:

    Nandrolone phenylpropionate

  • Synonyms:

    Estr-4-en-3-one,17-(1-oxo-3-phenylpropoxy)-,(17β)-;Estr-4-en-3-one,17β-hydroxy-,hydrocinnamate;Estr-4-en-3-one,17β-hydroxy-,phenylpropionate;Hydrocinnamic acid,ester with 17β-hydroxyestr-4-en-3-one;(17β)-17-(1-Oxo-3-phenylpropoxy)estr-4-en-3-one;Durabolin;17β-Hydroxyestr-4-en-3-one phenylpropionate;17β-Hydroxy-19-norandrost-4-en-3-one 17-phenylpropionate;Nandrolone phenpropionate;Nandrolone phenylpropionate;Nerobil;Norandrolone phenylpropionate;Norandrostenolone phenylpropionate;19-Norandrostenolone phenylpropionate;19-Nor-17β-hydroxy-3-ketoandrost-4-ene 17-phenylpropionate;19-Nortestosterone phenylpropionate;NPP;NTPP;Superanabolon;Nerobolil;17β-Hydroxy-4-estren-3-one17-phenylpropionate;Nortestosterone phenylpropionate;Fenobolin;Phenobolin;17β-(3-Phenylpropionyloxy)-estr-4-en-3-one;Nandrolon phenylpropionate;Nandrolin;Durabol;Activin (anabolic steroid);Nandrobolic;NSC 23162;Strabolene;Nandrosol

  • Categories:

    Active Pharmaceutical Ingredients  >  Hormones and the Endocrine System

Description

White to Off-White Solid


Solid


Nandrolone phenpropionate is a 3-phenylpropionate ester. It has a role as an anabolic agent and an androgen. It derives from a nandrolone.|Durabolin is a DEA Schedule III controlled substance. Substances in the DEA Schedule III have a potential for abuse less than substances in Schedules I or II and abuse may lead to moderate or low physical dependence or high psychological dependence.|C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of estradiol to resemble testosterone but less one carbon at the 19 position. It is a schedule III drug in the U.S.

Nandrolone phenylpropionate Basic Attributes

406.56

406.56

200-551-9

KF7Z9K2T3W

4000

23162

DTXSID2023353

2942000000

Characteristics

43.37000

5.97

Solid

1.1±0.1 g/cm3

95-96 °C

487.61°C (rough estimate)

234.6±30.2 °C

1.577

4.58e-04 g/L

Controlled Substance, -20?C Freezer

LD50 intraperitoneal in mouse: > 1gm/kg

D +58° (chloroform)

Safety Information

UN 1170 3/PG 2

3

20/21/22-40

23-36

Xn

P280-P301 + P312 + P330

H302 + H312-H351

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P322, P330, P363, P405, and P501|Aggregated GHS information provided by 55 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

58%

Drug Information

For the treatment of refractory deficient red cell production anemias, breast carcinoma, hereditary angioedema, antithrombin III deficiency, fibrinogen excess, growth failure and Turner's syndrome. It is also indicated in the prophylaxis of hereditary angioedema.

Nandrolone is an anabolic steroid occurring naturally in the human body, albeit in small quantities. Nandrolone increases production and urinary excretion of erythropoietin. It may also have a direct action on bone marrow. Nandrolone binds to the androgen receptor to a greater degree than testosterone, but due to its inability to act on the muscle in ways unmediated by the receptor, has less overall effect on muscle growth.

These compounds stimulate anabolism and inhibit catabolism. They stimulate the development of muscle mass, strength, and power. (See all compounds classified as Anabolic Agents.)

The absorption after oral dosing is rapid for testosterone and probably for other anabolic steroids, but there is extensive first-pass hepatic metabolism for all anabolic steroids except those that are substituted at the 17-alpha position. The rate of absorption from subcutaneous or intramuscular depots depends on the product and its formulation. Absorption is slow for the lipid-soluble esters such as the cypionate or enanthate, and for oily suspensions.

Nandrolone is unusual in that unlike most anabolic steroids, it is not broken down into the more reactive DHT by the enzyme 5α-reductase, but rather into a less effective product known as Dihydronandrolone.

The elimination half-life from plasma is very short.

Nandrolone is an androgen receptor agonist. The drug bound to the receptor complexes which allows it to enter the nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.

17 beta-hydroxyestr-4-en-3-one hydrocinnamate

Nandrolone|Deca-Durabolin, Durabolin, Durabolin-50|4000|Schedule III - Substances in the DEA Schedule III have a potential for abuse less than substances in Schedules I or II and abuse may lead to moderate or low physical dependence or high psychological dependence.|No

Nandrolone phenylpropionate Use and Manufacturing

Uses

Anabolic Steroid.

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Pharmaceuticals

Computed Properties

Molecular Weight:406.6
XLogP3:5.1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:406.25079494
Monoisotopic Mass:406.25079494
Topological Polar Surface Area:43.4
Heavy Atom Count:30
Complexity:703
Defined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is a protein anabolic hormone. It can increase the synthesis of protein from amino acids, inhibit the decomposition of amino acids to produce urea, and correct the negative nitrogen balance. The anabolic effect is stronger and more lasting than methyltestosterone, and the androgenic effect is weaker. It can accumulate calcium, phosphorus, potassium, sulfur and creatine, promote skeletal muscle development, body bone growth, and weight gain.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

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