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Colchicine

Colchicine structure

CAS No:
64-86-8
Formula:
C22H25NO6
Chemical Name:
Colchicine
Synonyms:
Acetamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-;Colchicine;Acetamide,N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-,(S)-;Benzo[a]heptalene,acetamide deriv.;N-[(7S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide;NSC 757;(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide;Colchineos;Colchisol;Colcin;Colsaloid;Condylon;(-)-Colchicine;Colcrys;(S)-N-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide;Mitigare;5843-86-7;30512-31-3
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM.

Colchicine Basic Attributes

Molecular Weight：

399.43700

Exact Mass：

399.44

EC Number：

200-598-5

HScode：

29399990

Characteristics

PSA：

83.09000

XLogP3：

3.26250

Appearance：

Colchicine appears as odorless or nearly odorless pale yellow needles or powder that darkens on exposure to light. Used to treat gouty arthritis, pseudogout, sarcoidal arthritis and calcific tendinitis. (EPA, 1998)

Density：

1.32 g/cm3

Melting Point：

142-150 °C

Boiling Point：

726.0±60.0 °C at 760 mmHg

Flash Point：

392.9ºC

Refractive Index：

1.584

Water Solubility：

H2O: 45 g/L (20 ºC)

Storage Conditions：

Poison room

Vapor Pressure：

3.2X10-11 mm Hg at 25 °C (est)

Toxicity：

LD50 in rats (mg/kg): 1.6 i.v. (Rosenbloom, Ferguson); in mice (mg/kg): 4.13 i.v. (Beliles)

Specific rotation：

Specific optical rotation: -429 at 17 °C/D (water, 1.72%); -121 deg at 17 °C/d (concentration by volume = 0.9 g in 100 ml chloroform); max absorption (95% ethanol): 350.5 nm (log epsilon = 4.22), 243 nm (log epsilon = 4.47)

Odor：

Odorless or nearly so

PH：

pH of 0.5% solution: 5.9

PKA：

12.36None

Safety Information

Packing level：

Hazard category：

6.1

Transport codes：

UN 1544

wgk germany：

hazard class code：

R26/28

safety instructions：

S13-S45

RTECS Number：

GH0700000

Marks：

T+

Stability/Shelf Life：

Stable. Light sensitive. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

Missing Phrase - N15.00950417-P201-P280-P304 + P340 + P310-P305 + P351 + P338 + P310-P308 + P313

Hazard Statements：

H300 + H330-H318-H340

Colchicine Use and Manufacturing

An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signal

Computed Properties

Molecular Weight:399.4
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:399.16818752
Monoisotopic Mass:399.16818752
Topological Polar Surface Area:83.1
Heavy Atom Count:29
Complexity:740
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Colchicine

Colchicine Tablets
Ingredients	The main ingredient of this product is colchicine, which is an alkaloid.
Indication	1. This product can cause reversible vitamin B12 malabsorption. 2. This product can enhance the efficacy of central nervous system depressants and the responsiveness of sympathomimetic drugs.
Specifications	0.5 mg
Manufacturer	Yunnan Phyto Pharmaceutical Co., Ltd.

Colchicine Tablets
Ingredients	The main ingredient of this product is colchicine, which is an alkaloid.
Indication	1. This product can cause reversible vitamin B12 malabsorption. 2. This product can enhance the efficacy of central nervous system depressants and the responsiveness of sympathomimetic drugs.
Specifications	1mg
Manufacturer	KPC Pharmaceuticals, Inc.

See More Related Drugs

Registered Holders

DR WILLMAR SCHWABE INDIA PVT LTD

United States
Active
INDENA SPA

France
Active
Nanjing Belger Pharmaceutical Technology Co., Ltd.

China
Active

See More Registered Holders

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