2,4,6-Trichloroaniline

196.46

196.46

879568

211-219-8

J7IC72N9B0

2114

2811

DTXSID6021379

CRYSTALS FROM ALCOHOL, NEEDLES FROM PETROLEUM ETHER

2921420090

26

3.69

Long needles or fine, light purple fibers. (NTP, 1992)

1.5±0.1 g/cm3

78.5 °C

262 °C @ Press: 746 Torr

262°C

1.626

H2O: <0.1 g/100 mL at 21.5 ºC

Storage temperature: no restrictions.

1.47X10-7 mm Hg @ 25 deg C

Oral-rat LD50: 2400 mg/kg; Oral-Mouse LD50: 1180 mg/kg

Open flame is flammable; burning releases toxic chloride and nitrogen oxide fumes

pKa= -0.03 (conjugate acid)

This compound may be sensitive to exposure to light and air. Insoluble in water.

Aryl Halides

2,4,6-TRICHLOROANILINE is incompatible with acids, acid chlorides, acid anhydrides, chloroformates, and strong oxidizing agents. (NTP, 1992).

II

6.1

UN 2811 6.1/PG 2

3

23/24/25-33-50/53

28-36/37-45-60-61-28A

BZ0250000

T,N

Storehouse ventilated at low temperature and dry; stored separately from acids, oxidants, food additives

Toxic

Stable, but may be light or air sensitive. Incompatible with acids, acid chlorides, acid anhydrides, chloroformates, strong oxidizing agents.

P261-P273-P280-P301 + P310-P311-P501

H301-H311-H331-H373-H410

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Flash point data for this chemical are not available. It is probably combustible. (NTP, 1992)

|Danger|H301 (33.57%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P261, P264, P270, P271, P272, P273, P280, P301+P310, P302+P352, P304+P340, P311, P312, P314, P321, P322, P330, P333+P313, P361, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 140 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Warning|H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]|P273, P391, and P501

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store it in a freezer. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Anilines, including trichloro isomers, are released to the environment during the industrial production of dyes and pigments and also during microbial and/or chemical degradation and photodecomposition of various pesticides(1).

moderately toxic

LD50 Rat oral 2400 mg/kg|LD50 Mouse oral 1180 mg/kg

2,4,6-Trichloroaniline's production and use as an intermediate in the manufacture of benzene derivatives, including 1,3,5-trichlorobenzene, and in the formulation of fungicides, mono-azo dyestuffs, and the preparation of hexachlorodiphenyl urea(1) may result in its release to the environment through various waste streams.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2,400(SRC), determined from a structure estimation method(2), indicates that 2,4,6-trichloroaniline is expected to have slight mobility in soil(SRC). There appears a rapid and spontaneous binding to soil organic matter and to purified humic and fulvic acid preparations(3). Therefore, soils containing high levels of organic matter are expected to attenuate soil mobility(SRC). Volatilization of 2,4,6-trichloroaniline from moist soil surfaces is expected to be a slow environmental fate process(SRC) given an estimated Henry's Law constant of 1.34X10-6 atm-cu m/mole(SRC), using a fragment constant estimation method(4). 2,4,6-Trichloroaniline is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.47X10-7 mm Hg(SRC), determined from a fragment constant method(5).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2,400(SRC), determined from a structure estimation method(2), indicates that 2,4,6-trichloroaniline is expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.34X10-6 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), a BCF of 214(6) suggests bioconcentration in aquatic organisms is high. A measured BCF of 870 was found using activated sludge from a municipal sewage treatment plant over a 5 day period(7).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2,4,6-trichloroaniline, which has a vapor pressure of 1.47X10-7 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase 2,4,6-trichloroaniline is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 14 days(SRC) from its estimated rate constant of 1.11X10-12 cu cm/molecule sec(3). Particulate-phase 2,4,6-trichloroaniline may be removed from the air by wet and dry deposition(SRC). 2,4,6-Trichloroanilne absorbs light in the environmental spectrum (>290 nm), and may undergo photolysis in the ambient environment. Photo-oxidation of 2,4,6-trichloroaniline was found to occur more readily in fulvic acid as opposed to humic acid(4). However, photo oxidation occurred more readily when not bound to any soil material than bound(5).

MONO-, DI-, & TRICHLOROANILINES WERE IRRADIATED IN METHANOL & METHANOL-H2O SOLN BY UV RADIATION; PRODUCTS WERE MONO-, DI-, & TRICHLOROAZOBENZENE.|The rate constant for the vapor-phase reaction of 2,4,6-trichloroaniline with photochemically-produced hydroxyl radicals has been estimated as 1.11X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 14 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 2,4,6-Trichloroaniline is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(3). It may directly photolyze due to absorbance in the environmental UV spectrum. Photooxidation of 2,4,6-trichloroaniline was found to occur more readily in fulvic acid as opposed to humic acid(4). However, photooxidation occurred more readily when not bound to any soil material than bound(5).

100.00|A BCF of 3,630 was measured for 2,4,6-trichloroaniline(1) when exposed to fish for a 96 hr period. This suggests the potential for bioconcentration in aquatic organisms is very high, according to a classification scheme(2).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for 2,4,6-trichloroaniline can be estimated to be about 2,400(SRC). According to a classification scheme(2), this estimated Koc value suggests that 2,4,6-trichloroaniline is expected to have slight mobility in soil. Also, covalent binding to humic substances is an important process in the formation of soil-bound residues of chlorinated anilines. Additionally, other mechanisms of soil-binding, such as entrapping of residues into cavities within the humus structure, or binding to mineral constituents, may also contribute to the phenomenon of bound residues of anilines in soil(3). Aromatic amines (such as various trichloro aniline isomers) have been observed to undergo rapid and reversible covalent bonding with humic materials in aqueous solution. The initial bonding reaction is followed by a slower and much less reversible reaction believed to represent the addition of the amine to quinoidal structures followed by oxidation of the product to give an amino-substituted quinone. These processes represent pathways by which aromatic amines may be converted to latent forms in the biosphere(4). There appears a rapid and spontaneous binding to soil organic matter and to purified humic and fulvic acid preparations. Therefore, a build up of 2,4,6-trichloroaniline in agricultural soils may occur(5).

The Henry's Law constant for 2,4,6-trichloroaniline is estimated as 1.34X10-6 atm-cu m/mole(SRC) from its experimental values for vapor pressure, 1.47X10-7 mm Hg(1), and water solubility, 40 mg/l(2). This Henry's Law constant indicates that 2,4,6-trichloroaniline is not expected to volatilize from water surfaces(3). 2,4,6-Trichloroaniline is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.47X10-7 mm Hg(1).

DRINKING WATER: 2,4,6-Trichloroaniline was detected, concentration not specified, in both finished drinking water and finished water from advanced water treatment. Finished drinking water samples originated from Cincinnati, OH, Miami, FL, New Orleans, LA, Ottumwa, IA, Philadelphia, PA, and Seattle, WA while finished water from advanced water treatment originated from Escondido, Lake Tahoe, Orange County and Pomona (California), Dallas, TX and Washington, D.C.

Occupational exposure to 2,4,6-trichloroaniline may occur through inhalation and dermal contact with this compound at workplaces where 2,4,6-trichloroaniline is produced or used(SRC). The general population may be exposed to 2,4,6-trichloroaniline via drinking water(1) and dermal contact with this compound in dyestuffs, pigments, and pesticides containing 2,4,6-trichloroaniline(2).

YIELDS 3-AMINO-2,4,6-TRICHLOROPHENOL & 4-AMINO-3,5-DICHLOROPHENOL IN RABBITS. /FROM TABLE/|ACARICIDE BENZOYL CHLORIDE PENETRATED SPIDER MITE RAPIDLY & WAS METABOLIZED SLOWLY TO 2,4,6-TRICHLOROANILINE AS ONE OF ITS MINOR METABOLITES.

4.68 Days

SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin and eyes. ACUTE/CHRONIC HAZARDS: This compound may be harmful by inhalation, ingestion or skin absorption. It is an irritant of the skin and eyes. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides, and hydrogen chloride gas. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

2,4,6-trichloraniline

Benzenamine, 2,4,6-trichloro-: ACTIVE

HIGH-POWERED LIQUID CHROMATOGRAPHY USED FOR SEPARATION OF UREA HERBICIDES & OF THEIR CHLOROANILINE METABOLITES. UV ABSORPTION DETECTOR WAS USED.