Glycine sodium
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Glycine sodium
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CAS No:
6000-44-8
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Formula:
C2H5NO2.Na
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Chemical Name:
Glycine sodium
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Synonyms:
Glycine,sodium salt (1:1);Glycine,monosodium salt;Sodium glycinate;Sodium glycine;Glycine sodium salt;Sodium aminoacetate;Sodium glycocollate;Glycine sodium;780026-07-5;1715918-71-0
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CAS No:
Description
Liquid
A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.
Characteristics
66.2
-1.60470
White to yellow Moist Beads
1.014g/cm3
290ºC decomposes
347°C at 760 mmHg
99.5ºC
1.491
Drug Information
Substances used for their pharmacological actions on glycinergic systems. Glycinergic agents include agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function. (See all compounds classified as Glycine Agents.)
Acid, Aminoacetic
Glycine sodium Use and Manufacturing
10 g (calculated on the basis of the dry substance) of a Pd-doped copper catalyst on active carbon (Degussa AG, CE 1015 OY/W) suspended in water was placed first analogously to in an autoclave and 61 g ethanolamine and 272 g sodium hydroxide solution (15percent by weight) were added. The autoclave was closed and the contents were heated to 160° C. The pressure was kept at 12 bar (absolute) and the hydrogen that formed was continuously discharged by a pressure control valve. After the end of the reaction (which is evident from the decrease in gas release) it was cooled to 90° C. and the catalyst was removed from the product solution by filtration. 315 g filtrate which contained 29.8 g percent by weight Na glycinate was obtained (corresponds to a yield of 96.7percent of theory).The filtered catalyst was suspended in 10 g water and fed back into subsequent batches.EXAMPLE 1Synthesis of Sodium Glvcinate Reagent CompositionA glass reactor vessel was charged with 25g glycerol, 13.5g of glycine and 7.0g of sodium hydroxide pellets. These were heated together at 120°C for one hour. Water was continuously distilled from the resultant reagent composition. This reagent composition provided a 100percent yield of sodium glycine in glycerol. This composition can be prepared as a pre-mix as herein described and then charged to a reactor with a fatty acid ester to conduct a reaction to produce cocoyi glycinate. Alternatively, the sodium glycine slurry and and glycerol can be formed in situ as is described in the following reaction scheme.General procedure: In a glove box, a 25 mL Schlenk flask was charged with a stirring bar, catalyst (0.005-0.01 mmol), NaOH or KOH (5.5-10 mmol), amino alcohol (1-5 mmol), water (0.3-0.5 mL) and dioxane (0-0.5 mL) under an atmosphere of nitrogen (see Table 9 for specific amounts used). The flask was taken out of the glove box, equipped with a condenser and the solution was refluxed (oil bath temperature 125° C.) with stirring in an open system under a flow of argon for 24 h. After cooling to room temperature, 1-5 mmol of pyridine was added to the crude reaction mixture as an internal standard. 0-2 mL water was added, leading to a homogeneous solution. Then 0.05 mL of the solution was dissolved in D
Used in the synthesis of organic products, industrial detergent intermediates and biochemical research
Finishing agents
1,000,000 - 10,000,000 lb
All other chemical product and preparation manufacturing|Glycine, sodium salt (1:1): ACTIVE
Computed Properties
Molecular Weight:97.05
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:97.01397265
Monoisotopic Mass:97.01397265
Topological Polar Surface Area:66.2
Heavy Atom Count:6
Complexity:46.8
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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