Guanethidine monosulfate
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Guanethidine monosulfate
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CAS No:
645-43-2
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Formula:
C10H22N4.H2O4S
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Chemical Name:
Guanethidine monosulfate
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Synonyms:
Guanidine,N-[2-(hexahydro-1(2H)-azocinyl)ethyl]-,sulfate (1:1);Guanidine,[2-(hexahydro-1(2H)-azocinyl)ethyl]-,sulfate (1:1);Azocine,guanidine deriv.;Guanethidine monosulfate;[2-(Hexahydro-1(2H)-azocinyl)ethyl]guanidine hydrogen sulfate;Guanethidine sulfate (1:1);1-(2-(Azocan-1-yl)ethyl)guanidine sulfate
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Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs
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CAS No:
Description
Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as norepinephrine.IC50 value:Target: Guanethidine is transported across the sympathetic nerve membrane by the same mechanism that transports norepinephrine itself (NET, uptake 1), and uptake is essential for the drug's action. Once guanethidine has entered the nerve, it is concentrated in transmitter vesicles, where it replaces norepinephrine.It may also inhibit the release of granules by decreasing
Guanethidine monosulfate Use and Manufacturing
It is an adrenal nerve blocker. Its role is to interfere with the release of norepinephrine from the sympathetic nerve endings, and it also depletes the storage of norepinephrine. Therefore, when the adrenal nerve impulses reach the ends, there is no longer enough media to transmit and sympathetic nerve activity Lower blood pressure, lower blood pressure, its antihypertensive effect is strong and lasting. Mainly used for hypertension with moderate and severe diastolic blood pressure, more stubborn hypertension and renal hypertension.
Registered Holders
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FARCHEMIA SRL
Inactive
United States
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DINAMITE DIPHARMA SPA
Inactive
United States
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