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Butylphthalide

Butylphthalide structure

CAS No:
6066-49-5
Formula:
C12H14O2
Chemical Name:
Butylphthalide
Synonyms:
1(3H)-Isobenzofuranone,3-butyl-;Phthalide,3-butyl-;3-Butyl-1(3H)-isobenzofuranone;Butylphthalide;3-n-Butylphthalide;3-Butylphthalide;(±)-3-Butylphthalide;3-Butyl-1,3-dihydro-2-benzofuran-1-one;3-Butyl-3H-2-benzofuran-1-one;L-3-N-Butylphthalide;L-NBP;93133-67-6
Categories:
Cosmetic Ingredient > Perfuming

Description

Butylphthalide(3-n-Butylphthalide) is an anti-cerebral-ischemia drug; first isolated from the seeds of celery, showed efficacy in animal models of stroke.IC50 value:Target:3-n-butylphthalide alleviates oxidative stress caused by chronic cerebral ischemia, improves cholinergic function, and inhibits amyloid beta accumulation, thereby improving cerebral neuronal injury and cognitive deficits [2]. Intragastric NBP administration to 4-month-old SAMP8 mice for 2 months significantly improved

colourless, oily liquid; warm-spicy herbaceous aroma

Butylphthalide is a member of benzofurans.|Butylphthalide has been used in trials studying the prevention of Restenosis.

Butylphthalide Basic Attributes

Molecular Weight：

190.24

Exact Mass：

190.24

EC Number：

228-000-8

HScode：

2932209090

Characteristics

PSA：

26.3

XLogP3：

2.8

Appearance：

colourless, oily liquid; warm-spicy herbaceous aroma

Density：

1.1±0.1 g/cm3

Boiling Point：

138-139 °C @ Press: 6 Torr

Flash Point：

128.3±22.2 °C

Refractive Index：

1.525

Water Solubility：

Slightly soluble in water; soluble in oil

Toxicity：

Oral-rat LD50: 2450 mg/kg

Flammability characteristics：

Thermal decomposition emits spicy and irritating smoke

Safety Information

Storage features：

Warehouse ventilated, low temperature and dry

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 125 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)|Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)

MeSH Entry Terms：

(S)-(-)-3-butylphthalide

Butylphthalide Use and Manufacturing

Manufacturing Info：

1(3H)-Isobenzofuranone, 3-butyl-: ACTIVE

Use Classification：

Food additives -> Flavoring Agents|Flavoring Agents -> JECFA Flavorings Index

Food Additive Classes：

Flavoring Agents

Computed Properties

Molecular Weight:190.24
XLogP3:2.8
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:190.099379685
Monoisotopic Mass:190.099379685
Topological Polar Surface Area:26.3
Heavy Atom Count:14
Complexity:212
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Butylphthalide is a synthetic racemic n-butylphthalide, which has the same structure as the natural L-apigenin. Clinical research results show that butylphthalide can improve the damage of central nervous system function in patients with acute ischemic stroke and promote the improvement of patients' neurological deficits. Animal pharmacodynamic studies have shown that butylphthalide can block multiple pathological links of brain damage caused by ischemic stroke, has a strong anti-cerebral ischemia effect, can significantly reduce the infarct area of local cerebral ischemia in rats, reduce brain edema, improve brain energy metabolism and microcirculation and blood flow in ischemic brain areas, inhibit nerve cell apoptosis, and has anti-cerebral thrombosis and anti-platelet aggregation effects. Butylphthalide may exert the above-mentioned pharmacodynamic effects by reducing arachidonic acid content, increasing the levels of NO and PGI2 in cerebral vascular endothelial cells, inhibiting glutamate release, reducing intracellular calcium concentration, inhibiting free radicals and increasing antioxidant enzyme activity.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Butylphthalide Sodium Chloride Injection
Ingredients	The active ingredient of this product is butylphthalide, and its chemical name is dl-3-butyl-1(3H)-isobenzofuranone. Chemical structure: Molecular formula: C12H14O2 Molecular weight: 190.24 Excipients: sodium chloride, hydroxypropyl-β-cyclodextrin, water for injection.
Indication	Not yet clear.
Specifications	100ml: 25mg butylphthalide and 0.9g sodium chloride

Butylphthalide soft capsule
Ingredients	Butylphthalide.
Indication	The only clinical study results of this product in combination with compound Danshen injection showed no significant effects. There is still a lack of research data on whether it interacts with other drugs.
Specifications	0.1g
Manufacturer	CSPC NBP Pharmaceutical Co., Ltd.

Butylphthalide
Manufacturer	CSPC NBP Pharmaceutical Co., Ltd.

Registered Holders

Zhejiang Liaoyuan Pharmaceutical Co., Ltd.

China
Active
Jilin Qijian Bio-Pharmaceutical Co., Ltd.

China
Active
Xiangbei Welman Pharmaceutical Co., Ltd.

China
Active

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Guide of Butylphthalide

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

Butylphthalide

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