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Trilithium citrate tetrahydrate

Trilithium citrate tetrahydrate structure

CAS No:
6080-58-6
Formula:
C6H8O7.4H2O.3Li
Chemical Name:
Trilithium citrate tetrahydrate
Synonyms:
1,2,3-Propanetricarboxylic acid,2-hydroxy-,lithium salt,hydrate (1:3:4);1,2,3-Propanetricarboxylic acid,2-hydroxy-,trilithium salt,tetrahydrate;Trilithium citrate tetrahydrate
Categories:
Organic Chemistry > Organometalate

Description

Citric acid trilithium salt tetrahydrate is a pharmaceutical and construction material, used in HPLC gradient elution for quantitative amino acid analysis.

Lithium citrate tetrahydrate is a hydrate that is the tetrahydrate form of lithium citrate. It is used as a source of lithium for the treatment of anxiety disorders, bipolar disorder, and depression. It has a role as an antidepressant. It contains a lithium citrate (anhydrous).|Lithium Citrate is the citrate salt of lithium, a monovalent cation with antimanic activity. Although the exact mechanism is unclear, lithium might exert its mood-stabilizing effect via reduction of catecholamine concentration mediated through transneuronal membrane transport of sodium ion by sodium-potassium-stimulated adenosine triphosphatase (Na-K-ATPase). Alternatively, lithium may decrease cyclic adenosine monophosphate (cAMP) concentrations, which would desensitize hormonal-sensitive adenylyl cyclase receptors. Furthermore, lithium, in recommended dosage, blocks the activity of inositol-1-phosphatase, thereby resulting in the subsequent decrease of postsynaptic second messengers, diacylglycerol and inositol triphosphate, that contribute to chronic cell stimulation by altering electrical activity in the neuron.

Trilithium citrate tetrahydrate Basic Attributes

Molecular Weight：

281.98

Exact Mass：

282.093811

EC Number：

213-045-8

UNII：

5Z6E9K79YV

NCI Thesaurus Code：

C61812

HScode：

29181500

Characteristics

PSA：

177.54000

Appearance：

White Fine Crystalline Powder

Melting Point：

112 °C

Boiling Point：

309.6ºC at 760 mmHg

Flash Point：

155.2ºC

Water Solubility：

H2O: 1 M at 20 °C, clear, colorless

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

Marks：

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents, reducing agents, bases.

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (41.54%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 65 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

Litarex

Trilithium citrate tetrahydrate Use and Manufacturing

Uses

alpha-glucosidase inhibitor, antidiabetic

Use Classification：

Human drugs -> Rare disease (orphan)

Computed Properties

Molecular Weight:282.1
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:2
Exact Mass:282.0937965
Monoisotopic Mass:282.0937965
Topological Polar Surface Area:145
Heavy Atom Count:20
Complexity:211
Covalently-Bonded Unit Count:8
Compound Is Canonicalized:Yes

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CAS No.: 6080-58-6

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Guide of Trilithium citrate tetrahydrate

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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