Conduritol B epoxide
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Conduritol B epoxide
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CAS No:
6090-95-5
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Formula:
C6H10O5
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Chemical Name:
Conduritol B epoxide
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Synonyms:
myo-Inositol,1,2-anhydro-;Inositol,1,2-anhydro-,myo-;DL-myo-Inositol,1,2-anhydro-;1,2-Anhydro-myo-inositol;Conduritol B epoxide;11000-80-9;83829-77-0
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CAS No:
Description
Conduritol B epoxide is an irreversible covalently bound acid β-glucosidase (GCase) inhibitor, with IC50s of 1 and 100 μM for β-glucosidase and α-glucosidase respectively.
1-D-1,2-anhydro-myo-inositol is a conduritol epoxide resulting from the formal epoxidation of the double bond of (+)-conduritol B. It has a role as an EC 3.2.1.48 (sucrose alpha-glucosidase) inhibitor and an EC 3.2.1.10 (oligo-1,6-glucosidase) inhibitor. It derives from a (+)-conduritol B. It is an enantiomer of a 1-L-1,2-anhydro-myo-inositol.
Safety Information
3
Moisture Sensitive
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)
conduritol B epoxide
Conduritol B epoxide Use and Manufacturing
Conduritol B Epoxide acts on b-glucosidases from widely differing sources to show a loss of enzymic activity: from various Aspergillus species, yeast, snail, sweet almonds, and mammals. The other enzymes that have been found to be covalently inhibited are a- glucosidase from yeast and the sucrase-isomaltase complex from rabbit small intestine. inhibitor of glucosidases
Computed Properties
Molecular Weight:162.14
XLogP3:-2.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Exact Mass:162.05282342
Monoisotopic Mass:162.05282342
Topological Polar Surface Area:93.4
Heavy Atom Count:11
Complexity:154
Defined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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