5-AMINOBENZENE-1,3-DIOLHYDROCHLORIDE

To phloroglucinol (10.0 g, 79.5 mmol), conc. ammonia water (conc.NHTo phloroglucinol (10.0 g, 79.5 mmol), conc. ammonia water (conc.NHTo 10 mL flask containing 5-Aminobenzene-1, 3-diol hydrochloride(1 mmol)was added 5mL dry acetonitrile and mixturewasstirred at room temperature. Then triethoxy(3-isocyanatopropyl)silane (1.5 mmol) was added under argon protection and solutionwas stirred under argon atmosphere for 48 h at room temperature.To the compound (14) (542 mg, 3.34 mmol) and imidazole (1.01 g, 14.8 mmol), THF (20.0 mL) was added under argon atmosphere. To the obtained solution, t-butyldimethyl silyl chloride (TBS-Cl) (2.02 g, 13.4 mmol) dissolved in THF (13.6 mL) was added with transfer under ice cooling, and then the resulting mixture was stirred at room temperature for 37 hours. The organic layer was sequentially washed with H2O and saturated saline, dried with addition of Na2SO4, subjected to natural filtration, and further concentrated. The obtained reaction mixture was purified with silica gel column chromatography (ethyl acetate/hexane = 1 : 50), to give the targeted compound, that is, the compound (15) as a white solid (72% yield rate, 937 mg yield amount). [0163] The NMR measurement result of the compound (15) was as described below. [0164] 1H NMR (600 MHz, CDCl3) delta0.18 (s, 12H), 0.96 (s, 18H), 3.54 (s, 2H), 5.78 (t, J = 2.0Hz, 1H), 5.84 (d, J = 2.0 Hz, 2H).5-Benzyloxycarboxyaminoresorcinol To a suspension of

Molecular Weight:161.58
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:3
Exact Mass:161.0243562
Monoisotopic Mass:161.0243562
Topological Polar Surface Area:66.5
Heavy Atom Count:10
Complexity:87.1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes