2-amino-4-phosphonobutyric acid
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2-amino-4-phosphonobutyric acid
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CAS No:
6323-99-5
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Formula:
C4H10NO5P
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Chemical Name:
2-amino-4-phosphonobutyric acid
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Synonyms:
2-Amino-4-phosphonobutanoic acid;DL-2-Amino-4-phosphonobutyric Acid, 98.0+ % (HPLC);Butanoic acid, 2-amino-4-phosphono-
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CAS No:
Description
DL-AP4 is a broad-spectrum glutamatergic antagonist. DL-AP4 (2.5 mM) inhibits electrically stimulated synaptic transmission in rabbit hippocampal slices. It also depresses depolarizations induced by NMDA , L-homocysteate, or kainate in isolated frog spinal cord when used at a concentration of 1 mM. DL-AP4 (0.2 mM) inhibits the accumulation of inositol induced by ibotenate , quisqualate, L-glutamate, and L-aspartate in rat hippocampal slices.
2-amino-4-phosphonobutyric acid Basic Attributes
183.1
183.10
354086|30079
White to off-white
2931900090
Characteristics
121
-5.5
1.628±0.06 g/cm3(Predicted)
229-231 °C(Solv: ethanol (64-17-5); water (7732-18-5))
491.7±55.0 °C(Predicted)
Soluble to 50 mM in water
2.19±0.10(Predicted)
Store at RT
Safety Information
Store at RT
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 42 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)|Drugs that bind to and activate excitatory amino acid receptors. (See all compounds classified as Excitatory Amino Acid Agonists.)
2-amino-4-phosphonobutanoic acid
2-amino-4-phosphonobutyric acid Use and Manufacturing
DL-2-Amino-4-phosphonobutanoic acid (AP4) is an amino-acid derivative reported to block cone signals in the rat retina. Improves learning and memory processes in passive and active avoidance situations in rats.
Computed Properties
Molecular Weight:183.10
XLogP3:-5.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:183.02965942
Monoisotopic Mass:183.02965942
Topological Polar Surface Area:121
Heavy Atom Count:11
Complexity:187
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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