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Koumine

Koumine structure

CAS No:
1358-76-5
Formula:
C20H22N2O
Chemical Name:
Koumine
Synonyms:
6,4-(Epoxymethano)-3,11b-methano-11bH-pyrido[4,3-c]carbazole,11c-ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-,(3S,4S,4aR,6R,11bS,11cS)-;Koumine;7,20(2H,19H)-Cyclovobasan,1,2,18,19-tetradehydro-3,17-epoxy-,(3R,7α,20α)-;6,4-(Epoxymethano)-3,11b-methano-11bH-pyrido[4,3-c]carbazole,7,20(2H,19H)-cyclovobasan deriv.;(3S,4S,4aR,6R,11bS,11cS)-11c-Ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-6,4-(epoxymethano)-3,11b-methano-11bH-pyrido[4,3-c]carbazole;2223614-73-9
Categories:
Natural Products > Alkaloids

Description

Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells[1]. Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities[3], protects against the development of arthritis in Rheumatoid arthritis (RA) animal models[2].

15-Ethenyl-13-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.02,10.04,9.010,15.012,17]icosa-2,4,6,8-tetraene is a member of indoles.

Koumine Basic Attributes

Molecular Weight：

306.407

Exact Mass：

306.40

DSSTox ID：

DTXSID30159530

Characteristics

PSA：

24.8

XLogP3：

2.30900

Density：

1.42

Melting Point：

168 °C @ Solvent: Acetone

Boiling Point：

436.5±45.0 °C(Predicted)

Flash Point：

217.8±28.7 °C

Refractive Index：

1.763

Drug Information

MeSH Entry Terms：

koumine

Computed Properties

Molecular Weight:306.4
XLogP3:2.5
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:306.173213330
Monoisotopic Mass:306.173213330
Topological Polar Surface Area:24.8
Heavy Atom Count:23
Complexity:615
Undefined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Koumine, CAS:1358-76-5

Unit Price: $10.1-11.11 /G FOB

CAS No.: 1358-76-5

Grade: Chemical Grade

Content: 99%

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Guide of Koumine

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
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