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Polymyxin B

Polymyxin B structure

CAS No:
1404-26-8
Chemical Name:
Polymyxin B
Synonyms:
Polymyxin B;8054-38-4
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Solid

A mixture of polymyxins B1 and B2, obtained from BACILLUS POLYMYXA strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for treatment of infections with gram-negative bacteria, but may be neurotoxic and nephrotoxic.

Polymyxin B Basic Attributes

Molecular Weight：

1189.450

Exact Mass：

1188.734253

EC Number：

215-768-4

DSSTox ID：

DTXSID1048467|DTXSID80858844

ATC Code：

A - Alimentary tract and metabolism|J - Antiinfectives for systemic use|S - Sensory organs

Characteristics

PSA：

490.66000

XLogP3：

-3.40

Density：

1.3±0.1 g/cm3

Boiling Point：

1572.3±65.0 °C at 760 mmHg

Flash Point：

904.7±34.3 °C

Refractive Index：

1.593

Water Solubility：

7.44e-02 g/L

Safety Information

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

Drug Indication：

Treatment of infections due to aerobic Gram-negative bacteria

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

polymyxin B(1)|Aerosporin

Polymyxin B Use and Manufacturing

Use Classification：

Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Veterinary Drug -> ANTIMICROBIAL_AGENT; -> JECFA Functional Classes

Food Additive Classes：

Veterinary Drug -> ANTIMICROBIAL_AGENT;

Computed Properties

Molecular Weight:1203.5
XLogP3:-2.5
Hydrogen Bond Donor Count:18
Hydrogen Bond Acceptor Count:18
Rotatable Bond Count:29
Exact Mass:1202.74992724
Monoisotopic Mass:1202.74992724
Topological Polar Surface Area:491
Heavy Atom Count:85
Complexity:2150
Undefined Atom Stereocenter Count:13
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Binds to the lipid-A portion of endotoxin, has bactericidal effects against Gram-negative organisms including Pseudomonas spp.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

FONOW- bacitracin, neomycin, polymyxin b, lidocaine hcl_ointment
Manufacturer	Zhejiang Fonow Medicine Co., Ltd.

FONOW- bacitracin, neomycin, polymyxin b, lidocaine hcl_ointment
Manufacturer	Zhejiang Fonow Medicine Co., Ltd.

Recommended Suppliers of Polymyxin B

XI'AN HORLDEN BIO INDUSTRIES INC Contact Supplier

CN
3 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical,Intermediate,5-amino-1mq,SLU-PP332,Tirzepatide,Peptide,KY19382,5-deazaflavin,Dihexa,Urolithin A

High Quality Pure 99% Polymyxin B Base Raw Powder CAS 1404-26-8

CAS No.: 1404-26-8

Grade: Pharmaceutical Grade

Content: 99%

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