Diethylenetriamine

103.17

103.17

605314

203-865-4

03K6SX4V2J

0620

446

2079

DTXSID2025050

YELLOW LIQUID|Colorless liquid|Colorless to yellow liquid ... [Note: Hygroscopic (i.e., absorbs moisture from the air)].

29212900

64.1

-1.3

Clear Liquid

0.9586 g/cm³ @ Temp: 20 °C

-39 °C

207 °C @ Press: 760 Torr

90 °C

n 20/D 1.484(lit.)

Miscible

Store below +30°C.

0.08 mm Hg ( 20 °C)

3.6 (vs air)

Oral-Rat LD50: 74 mg/kg; Abdominal cavity-mouse LD50: 71  mg/kg

Combustible in case of open flame, high temperature and strong oxidant; burning emits irritating smoke

1-10%(V)

AMMONIACAL ODOR

STRONGLY ALKALINE

Kb = 7.07X10-5|pKa = 10.45 @ 20 °C

CORROSIVE TO COPPER & ITS ALLOYS|1 MG/L EQIV TO 237 PPM; 1 PPM EQUIV TO 4.22 MG/U M|HYGROSCOPIC; WT/GAL= 7.9 LB @ 20 °C|Heat of vaporization: 487.7 J/g @ 40 kPa|For more Other Experimental Properties (Complete) data for DIETHYLENETRIAMINE (7 total), please visit the HSDB record page.

Soluble in water.

Amines, Phosphines, and Pyridines

DIETHYLENETRIAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

676 °F (USCG, 1999)|398.9 °C|358 °C

Flammable Limits In Air: 1%-10% (calculated)|Class IIIB Combustible Liquid: Fl.P. at or above 200°F.

The vapour is heavier than air.

456.4 J/g @ 0.1 MPa

II

8

UN 2079 8/PG 2

2

21/22-34-43-37-26

26-36/37/39-45-28

IE1225000

C,T+

Complete packaging, light loading and unloading; warehouse ventilated, away from open flame, high temperature, stored separately from oxidants and acids

Stable, but absorbs carbon dioxide from the air. Incompatible with strong oxidizing agents, copper and its alloys.

P260, P261, P264, P270, P271, P272, P280, P284, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P320, P321, P322, P330, P333+P313, P363, P403+P233, P405, P501

H302

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.|Incinerate in admixture with flammable solvent in furnace equipped with afterburner and scrubber. Recommendable method: Incineration. Peer-review: Mix with excess fuel due to low carbon content and high nitrogen content. (Peer-review conclusions of an IRPTC expert consultation (May 1985))

Explosive solutions of nitromethane in dichloromethane, sensitized by addition of 10-12% of /bis(2-aminoethyl)amine/, retained their sensitivity at -50 °C. Presence of 0-5% of the triamine considerable increases detonation sensitivity of nitromethane.|Cellulose nitrate of high surface area (dry or alcohol-wet guncotton or scrap) spontaneously ignited in contact with various amines used as curing agents for epoxy resins. These included ... diethylenetriamine.|Oxidizers, strong acids, cellulose nitrate [Note: May form explosive complexes with silver, cobalt, or chromium compounds. Corrosive to aluminum, copper, brass & zinc].

Special Hazards of Combustion Products: Irritating vapors are generated when heated. (USCG, 1999)|Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Above 97 °C explosive vapour/air mixtures may be formed.

|Danger|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P260, P261, P264, P270, P272, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P333+P313, P363, P405, and P501|H302+H312 (15.62%): Harmful if swallowed or in contact with skin [Warning Acute toxicity, oral; acute toxicity, dermal]|P260, P261, P264, P270, P271, P272, P280, P284, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P320, P321, P322, P330, P333+P313, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 4214 companies from 44 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H411 (100%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]|P273, P391, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.|P201, P202, P260, P261, P264, P270, P272, P280, P281, P285, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P304+P341, P305+P351+P338, P308+P313, P310, P312, P321, P322, P330, P333+P313, P342+P311, P363, P405, and P501|P201, P202, P260, P261, P264, P270, P271, P272, P280, P281, P284, P285, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P304+P341, P305+P351+P338, P308+P313, P310, P312, P320, P321, P322, P330, P333+P313, P342+P311, P361, P363, P403+P233, P405, and P501

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2016)

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced. Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. Provide: Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2016)|Amine respiratory cartridge mask; rubber gloves; splash-proof goggles.|Wear appropriate eye protection to prevent eye contact.|Wear appropriate personal protective clothing to prevent skin contact.|Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection.|Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.]|(See protection codes)

LOW, WHEN EXPOSED TO HEAT OR FLAME

Explosive limits , vol% in air: 1-10

Use water spray, dry chemical, alcohol foam or carbon dioxide. Discharge is effective for cooling of container, dilution, prevention of spread of the fire.|If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, carbon dioxide or dry chemical.|Wear goggles, self-contained breathing apparatus, and rubber overclothing (including gloves). ... Water or foam may cause frothing.

Overspread sufficient sodium bisulfate and sprinkle water. Drain into the sewer with abundant water.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|...DECR CONCN OF AMINE VAPORS BY GOOD VENTILATION AT ACTUAL PLACE WHERE THEY ARE EVOLVED. AMINES WITH HEAVY VAPORS (EG DIETHYLENETRIAMINE) SHOULD BE DRAWN OFF BY DESCENT.|If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Use water spray to disperse vapors and dilute standing pools of liquid.|Personnel protection: Avoid breathing vapors. Keep upwind. Avoid bodily contact with the material. Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. Wear positive pressure self-contained breathing apparatus when fighting fires involving this material.|For more Preventive Measures (Complete) data for DIETHYLENETRIAMINE (6 total), please visit the HSDB record page.

/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.|/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.|/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas.|/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.|For more DOT Emergency Guidelines (Complete) data for DIETHYLENETRIAMINE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Diethylenetriamine ... is a skin, eye, and respiratory irritant.

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 1 ppm (4 mg/cu m). Skin.

Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Personal protection: complete protective clothing including self-contained breathing apparatus.

Separated from strong oxidants, acids, organic nitro compounds and food and feedstuffs. Keep in a well-ventilated room.

A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C.

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. The effects may be delayed. Medical observation is indicated.

Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma.

NO open flames. Above 97 °C use a closed system, ventilation and explosion-proof electrical equipment.

PREVENT GENERATION OF MISTS! STRICT HYGIENE! IN ALL CASES CONSULT A DOCTOR!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

| 3 - Materials that, under emergency conditions, can cause serious or permanent injury.| 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.| 0 - Materials that in themselves are normally stable, even under fire conditions.

highly toxic

LD50 Mouse ip 71 mg/kg|LD50 Rat ip 74 mg/kg|LD50 Rat oral 1080 mg/kg|LD50 Guinea pig percutaneous 162 mg/kg|For more Non-Human Toxicity Values (Complete) data for DIETHYLENETRIAMINE (6 total), please visit the HSDB record page.

Diethylenetriamine may be released in emissions and wastewater during its manufacture and use as a chemical intermediate in the manufacture of wet strength resins, surfactant-softeners, corrosion inhibitors, gas and lube additives, epoxy curing agents, chelating agents, polyamide resins, and asphalt emulsifiers(1). Spills during transport, storage and use would also result in releases(SRC).

TERRESTRIAL FATE: If released on land, diethylenetriamine would principally leach into the ground. The only circumstance where biodegradation would be significant is where the microorganisms at the site are well acclimated. Some of the diethylenetriamine may volatilize from the soil surface. (SRC)|AQUATIC FATE: The fate of diethylenetriamine released into water is unknown. Volatilization and adsorption to sediment will not be significant loss mechanisms. Biodegradation would not be expected to be significant unless the microorganisms at the site were well acclimated. (SRC)|ATMOSPHERIC FATE: Diethylenetriamine emitted to the atmosphere will degrade by reaction with photochemically produced hydroxyl radicals. The estimated half-life for this reaction is 2.7 hr(1,SRC).

Aliphatic amines do not absorb radiation above 250 nm(1) so diethylenetriamine would not directly photolyze. In the atmosphere, diethylenetriamine will react with photochemically-produced hydroxyl radicals with an estimated rate constant of 1.43X10-10 cu cm/molecule-s(2). Assuming a hydroxyl radical concn of 5X10+5 radicals/cu cm, the estimated half-life of diethylenetriamine in the atmosphere would be 2.7 hr(SRC). Aliphatic polyamines undergo reactions typical of those primary and secondary amines. Some of these reactions that may be important environmentally include reactions with aldehydes to form 2-substituted imidazolines, carboxylic acids to form 1,2-disubstituted imidazolines(3); however, no information specific to diethylenetriamine could be located.

4.47|Diethylenetriamine has a very low estimated log octanol/water partition coefficient, -2.13(1), and, therefore, would not be expected to bioconcentrate in fish(SRC).

The Koc for diethylenetriamine estimated from molecular structure is 88(1). Therefore, it would not be expected to adsorb significantly to soil or sediment. According to a suggested classification scheme(2), this estimated Koc suggests that diethylenetriamine would be highly mobile in soil(SRC).

Diethylenetriamine is miscible in water(3), has a pKa of 10.45(1), and therefore mostly ionized in solution at environmental pH's and has an extremely low estimated Henry's Law constant of 1X10-14 atm-cu m/mole(2). Therefore it would not be expected to volatilize appreciably from water. Its vapor pressure is 0.23 mm Hg at 25 °C(1) and therefore it would volatilize slowly from soil and other surfaces. (SRC)

Exposure to diethylenetriamine would be primarily occupational via inhalation and dermal contact. (SRC)|Exposure to diethylenetriamine will be primarily in the workplace where it is manufactured or used(SRC). NIOSH (NOES Survey 1981-1983) has statistically estimated that 50,637 workers are exposed to diethylenetriamine in the USA(1). Ninety-two percent of these exposures are with tradename products containing diethylenetriamine(1).

EXPL THER: Diethylenetriamine at 1% conc in water, adjusted with boric acid to between pH 7.2 and 8.5, has been used as an irrigating fluid on the surface of eyes of rabbits, causing no irritation or injury, and is said to be effective as a neutralizing solution in treatment of experimental burns of rabbit eyes with sulfuric acid and hydrochloric acid if started within fifteen min after exposure to the acid.|EXPL THER: In treatment of 45 patients with burns of the eye from contact with inorganic acids, organic acids, phenol, and aldehydes, this same solution is said to have been helpful if used within ten to fifteen min. Some benefit has been claimed even when used within ninety min. What local side effect this treatment may produce in patients who are allergic or hypersensitive to diethylenetriamine remains to be seen.

A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81) (See all compounds classified as Nitric Oxide Donors.)

Diethylenetriamine is readily absorbed through the gastrointestinal tract and 96% of the administered dose is excreted withing 48 hr. Roughly equal amounts are excreted in the feces and urine with at least 4 metabolites being detected (but not identified) in the latter. Only a small proportion (<2%) was recovered as expired carbon dioxide. Any residual remaining in the animal was found primarily in kidney, liver, bladder and large intestine.

... The mechanism of action /for pulmonary or dermal sensitization/ is probably a cross-linking of proteins with bifunctional amine groups.

Prolonged breathing of vapors may cause asthma. Liquid burns skin and eyes. A skin rash can form. (USCG, 1999)|Corrosives

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital. (NTP, 1992)|(See procedures)

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

EARLY TREATMENT FOR CORROSIVE BURNS OF ESOPHAGUS CONSISTS OF IV FLUID THERAPY, BROAD SPECTRUM ANTIBIOTICS, SEDATION, PARENTERAL HYDROCORTISONE & MORE IMPORTANTLY MAINTAINING PATENCY OF ESOPHAGUS FOLLOWED BY DILATATION. /ALKALIES/

Diethylenetriamine is characterized by its capacity to cause severe corneal injury and pulmonary and cutaneous sensitization in humans. Solutions of from 15% to 100% caused lasting corneal damage; 5% only minor injury; and unless properly controlled, the vapor and liquid cause sensitization of the respiratory tract and skin with relatively high frequency. Pulmonary and cutaneous sensitization occur with relatively high frequency unless adequate measures are taken to control all contacts. ... Little exposure is necessary in some cases to induce a high degree of sensitivity.|IT IS A POTENT PRIMARY SKIN IRRITANT, CAUSING EDEMA & SOMETIMES NECROSIS. THE SKIN IRRITATION IS FREQUENTLY COMPLICATED BY A HIGH INCIDENCE OF ALLERGIC SKIN SENSITIZATION. THE MAJORITY OF WORKERS CHRONICALLY EXPOSED TO IT BECOME SENSITIZED.|Symptoms: Conjunctivitis, keratitis (inflammation of the cornea), dermatitis, irritation of respiratory tract; asthmatic breathing, nausea, vomiting.|In addition to being an irritant, the polyamines typified by ... diethylenetriamine ... have been reported to cause dermal and pulmonary sensitization.|For more Human Toxicity Excerpts (Complete) data for DIETHYLENETRIAMINE (6 total), please visit the HSDB record page.

diethylene triamine

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.|inhalation, skin absorption, ingestion, skin and/or eye contact

irritation eyes, skin, mucous membrane, upper respiratory system; dermatitis, skin sensitization; eye, skin necrosis; cough, dyspnea (breathing difficulty), pulmonary sensitization

Sore throat. Cough. Burning sensation. Laboured breathing. Symptoms may be delayed.

Pain. Serious skin burns.

Pain. Severe deep burns. Loss of vision.

Eyes, skin, respiratory system

Grade: Technical

All other basic organic chemical manufacturing|1,2-Ethanediamine, N1-(2-aminoethyl)-: ACTIVE

Health Hazards -> Corrosives