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Gramicidin

Gramicidin structure

CAS No:
1405-97-6
Chemical Name:
Gramicidin
Synonyms:
Gramicidin;Gramicidins;Gramoderm;12687-70-6
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

White, crystalline platelets. Soluble in lower alcohols, acetic acid, and pyridine; moderately soluble in dry acetone and dioxane; almost insoluble in water, ether, and hydrocarbons. Depresses surface tension, forms a fairly stable colloidal emulsion in distilled water.An antibiotic produced by the metabolic processes of the bacteria Bacillus brevis. It is a polypeptide that is active against most Gram-positive pathogenic bacteria.

Gramicidin is a heterogeneous mixture of six antibiotic peptides obtained from the soil bacterium Bacillus brevis. Gramicidin is active against most Gram-positive bacteria and against select Gram-negative organisms. It is administered as a topical application.|A group of peptide antibiotics from BACILLUS brevis. Gramicidin C or S is a cyclic, ten-amino acid polypeptide and gramicidins A, B, D are linear. Gramicidin is one of the two principal components of TYROTHRICIN.

Gramicidin Basic Attributes

Molecular Weight：

1882.332

Exact Mass：

1881.07000

EC Number：

215-790-4

NCI Thesaurus Code：

C65816

ATC Code：

R - Respiratory system

HScode：

2941906000

Characteristics

PSA：

549

XLogP3：

11.26260

Melting Point：

228-230 °C @ Solvent: Acetone

Water Solubility：

soluble in acetic acid and lower alcohols. Practically insoluble in water.

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

20/21-36/37/38

safety instructions：

26-36-24/25-22

RTECS Number：

MD8225000

Marks：

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)|Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)

MeSH Entry Terms：

Gramicidin

Gramicidin Use and Manufacturing

Uses

Gramicidins are a family of linear pentadecapeptides isolated from Bacillus brevis by Dubos at the Rockefeller Institute in 1939. Gramicidin is a complex of six closely related analogues A1, A2, B1, B2, C1 and C2 where A1 and A2 are the dominant components. Gramidicins act by forming channels in cell membranes causing ion leakage, and is an essential bioprobe for understanding the nature of the cell membranes.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:1882.3
XLogP3:10.7
Hydrogen Bond Donor Count:21
Hydrogen Bond Acceptor Count:17
Rotatable Bond Count:52
Exact Mass:1882.07388791
Monoisotopic Mass:1881.07053308
Topological Polar Surface Area:549
Heavy Atom Count:136
Complexity:3980
Defined Atom Stereocenter Count:14
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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