1,2-Bis(2-chloroethoxy)ethane

187.06

187.06

506177

203-952-7

28JQ82M13J

DTXSID8047000

Colorless liquid

29091900

18.5

1.1

clear to slightly yellow liquid

1.1974 g/cm³ @ Temp: 20 °C

-31.5 °C

241.3 °C

250 °F

n 20/D 1.461(lit.)

insoluble

2-8°C

0.06 mm Hg @ 20 deg C

Wt/gal: 10.0 lbs/gal at 20 °C

1,2-Bis(2-chloroethoxy)ethane|D: Other compounds that may form peroxides|Kelly

III

6.1

UN 2810 6.1/PG 3

3

19-21/22-37/38-41-36/37/38

26-36/37/39

KH4900000

Xn

Stable under normal temperatures and pressures.

P261-P280-P301 + P310-P305 + P351 + P338

H301-H312-H315-H318-H335

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Combustible when exposed to heat or flame; can react with oxidizing materials.

|Danger|H301 (94.44%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 54 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H301: Toxic if swallowed [Danger Acute toxicity, oral]|P260, P264, P270, P280, P301+P310, P302+P352, P309+P311, P312, P314, P321, P322, P330, P363, P405, and P501

Water or foam may cause frothing.|To fight fire use carbon dioxide or dry chemical.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

A skin and eye irritant.

| 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.| 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.| 0 - Materials that in themselves are normally stable, even under fire conditions.

Effluent samples collected from an industrial chemical plant near Philadelphia, PA (on the Delaware River) in late Aug 1977 contained a 1,2-bis(2-chloroethoxy)ethane level of 100 ppb(1).

LD50 Guinea pig oral 120 mg/kg|LD50 Rabbit dermal 1410 mg/kg|LD50 Rat oral 250 mg/kg

Natural sources of 1,2-bis(2-chloroethoxy)ethane release to the environment is reported as none(1).

1,2-Bis(2-chloroethoxy)ethane's production and use as a solvent and chemical intermediate(1) may result in its release to the environment through various waste streams(SRC). A gross estimate of annual industrial discharge (as of 1975) is 30 tons(2). It has been suggested that 1,2-bis(2-chloroethoxy)ethane is possibly created during drinking water treatment by chlorination of diethoxyethane(2).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 19(SRC), determined from a water solubility of 18,900 mg/l(2) and a regression-derived equation(3), indicates that 1,2-bis(2-chloroethoxy)ethane is expected to have very high mobility in soil(SRC). Volatilization of 1,2-bis(2-chloroethoxy)ethane from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 7.8X10-7 atm-cu m/mole(SRC), derived from its vapor pressure, 0.06 mm Hg(2), and water solubility, 18,900 mg/l(2). 1,2-Bis(2-chloroethoxy)ethane is not expected to volatilize from dry soil surfaces(SRC) based upon a its vapor pressure(2). 1,2-Bis(2-chloroethoxy)ethane is moderately resistent (eg, 2 to 18 months) to biodegradation(4). The compound was not degraded by bacteria isolated from soil enriched with triethylene glycol(5).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 19(SRC), determined from a water solubility of 18,900 mg/l(2) and a regression-derived equation(3), indicates that 1,2-bis(2-chloroethoxy)ethane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 7.8X10-7 atm-cu m/mole(SRC), derived from its vapor pressure, 0.06 mm Hg(2), and its water solubility(2). According to a classification scheme(4), an estimated BCF of 2(SRC), from its water solubility(2) and a regression-derived equation(5), suggests the potential for bioconcentration in aquatic organisms is low(SRC). 1,2-Bis(2-chloroethoxy)ethane is moderately resistent (eg, 2 to 18 months) to biodegradation(6). The compound was not degraded by bacteria isolated from soil enriched with triethylene glycol(7).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,2-bis(2-chloroethoxy)ethane, which has a vapor pressure of 0.06 mm Hg at 20 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere(SRC). Vapor-phase 1,2-bis(2-chloroethoxy)ethane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.8 days(SRC), calculated from its rate constant of 8.9X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3).

The rate constant for the vapor-phase reaction of 1,2-bis(2-chloroethoxy)ethane with photochemically-produced hydroxyl radicals has been estimated as 8.9X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 1.8 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 1,2-Bis(2-chloroethoxy)ethane is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2) nor to directly photolyze due to the lack of absorption in the environmental portion of the UV spectrum (>290 nm)(SRC).

An estimated BCF of 2 was calculated for 1,2-bis(2-chloroethoxy)ethane(SRC), using a water solubility of 18,900 mg/l(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of is estimated as 19(SRC), using a water solubility of 18,900 mg/l(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 1,2-bis(2-chloroethoxy)ethane is expected to have very high mobility in soil(SRC).

The Henry's Law constant for 1,2-bis(2-chloroethoxy)ethane is estimated as 7.8X10-7 atm-cu m/mole(SRC) derived from its vapor pressure, 0.06 mm Hg(1), and water solubility, 18,900 mg/l(1). This Henry's Law constant indicates that 1,2-bis(2-chloroethoxy)ethane is expected to be essentially nonvolatile from water surfaces(2). 1,2-Bis(2-chloroethoxy)ethane is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

DRINKING WATER: 1,2-Bis(2-chloroethoxy)ethane was qualitatively detected in drinking water samples collected from the Torresdale Water Treatment Plant (Philadelphia, PA) during 8 sampling periods between Feb 1975 and Jan 1977(1). It has been tentatively detected in drinking water samples collected from Cincinnati, OH (Oct 1978)(2). A concn of 0.03 ug/l has been reported for drinking water samples from Philadelphia, PA (collection date not reported)(3).|SURFACE WATER: A 1,2-bis(2-chloroethoxy)ethane concn of 15 ppb was detected in samples collected from the Delaware River between Marcus Hook, PA and Trenton, NJ in March 1977(1); it was not detected (detection limit not reported) in samples collected in August, 1976(1). Concn of 0.03 ug/l were detected in the Rhine River (Netherlands) in Oct 1979 near Lobith and Maassluis(2).

NIOSH (NOHS Survey 1972 1974) has statistically estimated that 125 workers are potentially exposed to 1,2-bis(2-chloroethoxy)ethane in the USA(1). Occupational exposure to 1,2-bis(2-chloroethoxy)ethane may occur through inhalation and dermal contact with this compound at workplaces where 1,2-bis(2-chloroethoxy)ethane is produced or used(SRC). Monitoring data indicate that the general population may be exposed to 1,2-bis(2-chloroethoxy)ethane via ingestion of drinking water containing 1,2-bis(2-chloroethoxy)ethane(SRC).

Acidity as HCl, 0.01% by wt, max

/SRP:/ Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Provide a low-stimulus environment. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Treat frostbite by rapid rewarming ... . /Ethers and related compounds/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in respiratory arrest. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Ethers and related compounds/

GRADE: TECHNICAL.|97%

Ethane, 1,2-bis(2-chloroethoxy)-: ACTIVE

Method: EPA-EAD 611, Haloethers in Water by GC/Electrolytic Conductivity Detector; Analyte: bis(2-chloroethoxy)methane; Matrix: water; Detection Level: 0.5 ug/L. /Bis(2-chloroethoxy)methane/|Method: EPA-NERL 625, Base/Neutrals and Acids; Analyte: bis(2-chloroethoxy)methane; Procedure: GC/MS; Matrix: water; Detection Level: 5.3 ug/L. /Bis(2-chloroethoxy)methane/|Method: EPA-OSW 8270D, Semivolatile Organic Compounds by GC/MS; Analyte: bis(2-chloroethoxy)methane; Matrix: various (solid waste matrices, soils, air sampling media and water samples); Detection Level: 10 ug/L. /Bis(2-chloroethoxy)methane/|Method: DOE OM100R, Semivolatile Organic Compounds in Multimedia Samples by Capillary Column Ion Trap MS; Analyte: bis(2-chloroethoxy)methane; Matrix: water; Detection Level: 56 ug/L. /Bis(2-chloroethoxy)methane/|For more Analytic Laboratory Methods (Complete) data for 1,2-BIS(2-CHLOROETHOXY)ETHANE (6 total), please visit the HSDB record page.