Azaribine
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Azaribine
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CAS No:
2169-64-4
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Formula:
C14H17N3O9
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Chemical Name:
Azaribine
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Synonyms:
1,2,4-Triazine-3,5(2H,4H)-dione,2-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-;as-Triazine-3,5(2H,4H)-dione,2-β-D-ribofuranosyl-,2′,3′,5′-triacetate;2-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)-1,2,4-triazine-3,5(2H,4H)-dione;CB 304;Azaribine;Triazure;2′,3′,5′-Tri-O-acetyl-6-azauridine;6-Azauridine triacetate;Azaribin;6-Aza-2′,3′,5′-tri-O-acetyluridine;NSC 67239
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CAS No:
Description
white to off-white powder or crystals
Azaribine is a N-glycosyl-1,2,4-triazine that is 6-azauridine acetylated at positions 2', 3' and 5' on the sugar ring. It is a prodrug for 6-azauridine and is used for treatment of psoriasis. It has a role as an antipsoriatic and a prodrug. It is an acetate ester and a N-glycosyl-1,2,4-triazine. It derives from a 6-azauridine.|Azaribine is the triacetate salt of azauridine, a synthetic triazine nucleoside derivative possessing antineoplastic and anti-psoriatic activity. After metabolism to 6-azauridine-5-prime monophosphate, 6-Azauridine inhibits de novo pyrimidine biosynthesis and its 5-prime triphosphate metabolite gets incorporated into RNA, thereby preventing RNA synthesis.
Drug Information
Drugs used to treat or prevent skin disorders or for the routine care of skin. (See all compounds classified as Dermatologic Agents.)
2-beta-D-ribofuranosyl-as-triazine-3,5(2H,4H)-dione 2',3',5'-triacetate
Computed Properties
Molecular Weight:371.30
XLogP3:-0.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:8
Exact Mass:371.09647913
Monoisotopic Mass:371.09647913
Topological Polar Surface Area:150
Heavy Atom Count:26
Complexity:662
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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