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5-Demethylnobiletin

5-Demethylnobiletin structure

CAS No:
2174-59-6
Formula:
C20H20O8
Chemical Name:
5-Demethylnobiletin
Synonyms:
4H-1-Benzopyran-4-one,2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-;Flavone,5-hydroxy-3′,4′,6,7,8-pentamethoxy-;2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one;5-O-Demethylnobiletin;5-Hydroxy-6,7,8,3′,4′-pentamethoxyflavone;5-Hydroxy-3′,4′,6,7,8-pentamethoxyflavone;5-O-Desmethylnobiletin;5-Desmethylnobiletin;5-Demethylnobiletin;NSC 618927;2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxychromen-4-one
Categories:
Biochemical Engineering > Plant Extracts

Description

5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Sideritis tragoriganum, is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM[1].5-O-Demethylnobiletin (5-demethylnobiletin) promotes neuritogenesis through the activation

Solid

Demethylnobiletin is an ether and a member of flavonoids.

5-Demethylnobiletin Basic Attributes

Molecular Weight：

388.37

Exact Mass：

388.37

UNII：

OGE0V42MOT

NSC Number：

618927

DSSTox ID：

DTXSID60176134

HScode：

2914509090

Characteristics

PSA：

92.7

XLogP3：

3.2

Appearance：

Solid

Density：

1.304±0.06 g/cm3

Melting Point：

145 °C

Boiling Point：

601.4°C at 760 mmHg

Flash Point：

213.9±25.0 °C

Refractive Index：

1.583

Water Solubility：

H2O: Practically insoluble (0.058 g/L) (25 ºC)

Vapor Pressure：

4.68E-15mmHg at 25°C

Collision Cross Section：

186.6 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

5-Demethylnobiletin Use and Manufacturing

Use Classification：

Polyketides [PK] -> Flavonoids [PK12] -> Flavones and Flavonols [PK1211]

Computed Properties

Molecular Weight:388.4
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:388.11581759
Monoisotopic Mass:388.11581759
Topological Polar Surface Area:92.7
Heavy Atom Count:28
Complexity:579
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of 5-Demethylnobiletin

Description
Basic Attributes
Characteristics
Use and Manufacturing
Computed Properties
Learn More Other Chemicals

5-Demethylnobiletin

SDS

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