Phenethyl bromide

185.06

185.06

507487

203-130-8

96O442668X

33926

DTXSID1033876

29036990

0

3.1

Clear colorless to pale yellow Liquid

1.355 g/cm³

-67.5 °C

219 °C

193 °F

n 20/D 1.556(lit.)

H2O: INsoluble

2-8°C

Vapor pressure = 0.2445 mm Hg at 25 deg C

UN 1993 / PGIII

3

22-36-36/37/38

26-37/39-39

CY9032000

Xn

Stable. Incompatible with strong oxidizing agents.

P305 + P351 + P338

H302-H319

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

|Warning|H302 (98.8%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P332+P313, P337+P313, P362, and P501|Aggregated GHS information provided by 83 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H227: Combustible liquid [Warning Flammable liquids]|P210, P260, P264, P270, P280, P301+P312, P309+P311, P330, P370+P378, P403+P235, P405, and P501

(2-Bromoethyl)benzene's use as a starting material for the production of various beta-phenethyl derivatives, pharmaceuticals, fragrances, and other fine chemicals(1) could result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: (2-Bromoethyl)benzene will have low mobility(3) in soil based on estimated Koc values of 581.6 and 955(1,2,SRC). Insufficient data are available to determine the rate or importance of biodegradation of (2-bromoethyl)benzene in soil conditions. Volatilization of (2-bromoethyl)benzene is expected from moist and dry soils based on an experimental vapor pressure of 0.2445 mm Hg at 25 °C(4) and an Henry's Law constant of 1.52X10-3 atm cu m/mole estimated from an experimental water solubility of 39.05 mg/l(4) and a vapor pressure of 0.2445 mm Hg(4).|AQUATIC FATE: (2-Bromoethyl)benzene is expected to volatilize rapidly from water(1) based upon an estimated Henry's Law constant of 1.52X10-3 atm cu m/mol estimated from an experimental water solubility of 39.05 mg/L(2) and a vapor pressure of 0.2445 mm Hg(2). Based on this Henry's Law constant the volatilization half-life from a model river (1 meter deep flowing 1 m/sec with a wind velocity of 3 m/sec) can be estimated to be about 4.8 hours(1,SRC). The volatilization half-life from a model lake (1 meter deep) can be estimated to be about 5.6 days(1,SRC). Insufficient data are available to determine the rate or importance of biodegradation of (2-bromoethyl)benzene in aquatic conditions(SRC). Aquatic bioconcentration and adsorption to sediment may be important fate processes in aquatic systems based on an estimated BCF of 78(1,SRC) and estimated Koc values of 582 and 955(1,3,SRC) but hydrolysis is not expected to be important(SRC).|ATMOSPHERIC FATE: Based on an experimental vapor pressure of 0.2445 mm Hg at 25 °C(1), (2-bromoethyl)benzene will exist in the atmosphere in the vapor phase(2). It will degrade in the atmosphere by reaction with photochemically produced hydroxyl radicals with an estimated half-life of 2.87 days(3). Removal of (2-bromoethyl)benzene from the atmosphere can occur through wet deposition(SRC).

The rate constant for the vapor-phase reaction of (2- bromoethyl)benzene with photochemically produced hydroxyl radicals has been estimated to be approximately 5.59X10-12 cu cm/molecule-sec at 25 °C, which corresponds to an atmospheric half-life of about 2.9 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC).

Based upon an experimental water solubility of 39.05 mg/l(1), the BCF of (2-bromoethyl)benzene can be estimated to be approximately 78 from a regression-derived equation(2). This estimated BCF value suggests that bioconcentration in aquatic organisms may be an important fate process(SRC).

Using a structure estimation method based on molecular connectivity indices, the Koc for (2-bromoethyl)benzene can be estimated to be about 955(1). The Koc for (2-bromoethyl)benzene can also be estimated to be about 582 based on an experimental water solubility of 39.05 mg/l(3) and a regression derived equation(2). According to a suggested classification scheme(4), these estimated Koc values suggest that (2-bromoethyl)benzene has low soil mobility.

The Henry's Law constant for (2-bromoethyl)benzene can be estimated to be 1.52X10-3 atm-cu m/mole based on an experimental water solubility of 39.05(1) and an experimental vapor pressure of 0.2445(1). This value of the Henry's Law constant indicates that volatilization of (2-bromoethyl)benzene from water is rapid(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 meter deep flowing 1 m/sec with a wind velocity of 3 m/sec) can be estimated to be about 4.8 hours(2,SRC). The volatilization half-life from a model lake (1 meter deep) can be estimated to be about 5.6 days(2,SRC).

Occupational exposure to bromine and compounds, such as (2-bromoethyl)benzene(SRC), can occur through dermal contact, inhalation, and ingestion(1).

AFTER INJECTING (2-BROMOETHYL)BENZENE IN RATS ONLY N-ACETYL-S-2-PHENYLETHYLCYSTEINE & N-ACETYL-S-(2-PHENYL-2-HYDROXYETHYL)CYSTEINE WERE FOUND IN URINE. INTERMEDIATE FORMATION OF STYRENE OR STYRENE OXIDE DOES NOT OCCUR.|THE CHIEF SULFUR CONTAINING URINARY METABOLITE OF PHENETHYL BROMIDE IN RAT & RABBIT WAS CHROMATOGRAPHICALLY IDENTIFIED AS N-ACETYL-S-BETA-HYDROXYPHENETHYL-L-CYSTEINE (HYDROXYPHENETHYLMERCAPTURIC ACID) & N-ACETYL-S-PHENETHYL-L-CYSTEINE (PHENETHYLMERCAPTURIC ACID). AMT OF PHENETHYLMERCAPTURIC ACID & HYDROXYPHENETHYLMERCAPTURIC ACID EXCRETED IN URINE OF RABBITS & RATS DOSED BY STOMACH TUBE WERE 11.8 & 6.1, 14.2 & 1.9 OF DOSE RESPECTIVELY. RAT LIVER SLICES CONVERTED PHENETHYLCYSTEINE & PHENETHYLMERCAPTURIC ACID INTO N-ACETYL-S-BETA-HYDROXYPHENETHYL-L-CYSTEINE.

(2-bromoethyl)benzene

All other chemical product and preparation manufacturing|Benzene, (2-bromoethyl)-: ACTIVE