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(-)-Vindoline

(-)-Vindoline structure

CAS No:
2182-14-1
Formula:
C25H32N2O6
Chemical Name:
(-)-Vindoline
Synonyms:
Aspidospermidine-3-carboxylic acid,4-(acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methyl-,methyl ester,(2β,3β,4β,5α,12R,19α)-;Vindoline,(-)-;Aspidospermidine-3-carboxylic acid,4-(acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methyl-,methyl ester,(2β,3β,4β,5α,12β,19α)-;1H-Indolizino[8,1-cd]carbazole,aspidospermidine-3-carboxylic acid deriv.;Vindolin;(-)-Vindoline;Vindoline;NSC 91994;7616-06-0
Categories:
Natural Products > Alkaloids

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Description

Vindoline, a vinca alkaloid extracted from the leaves of Catharanthus roseus, weakly inhibits tubulin self-assembly[1].

(-)-Vindoline Basic Attributes

Molecular Weight：

456.53

Exact Mass：

456.53

EC Number：

218-558-0

HScode：

29339900

Characteristics

PSA：

88.54000

XLogP3：

2.20

Appearance：

White or offwhite powder

Density：

1.3±0.1 g/cm3

Melting Point：

164-165 °C

Boiling Point：

569.8±50.0 °C at 760 mmHg

Flash Point：

298.4±30.1 °C

Refractive Index：

1.626

Storage Conditions：

-20°C Freezer

Vapor Pressure：

0mmHg at 25°C

Specific rotation：

D20 -18° (chloroform); D27 +42° (chloroform)

Safety Information

Transport codes：

NONH for all modes of transport

hazard class code：

safety instructions：

36/37-24/25

RTECS Number：

CJ0120000

Marks：

Precautionary statement(s)：

P281

Hazard Statements：

H341

GHS Classification：

|Warning|H341 (97.5%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]|P201, P202, P281, P308+P313, P405, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

vindoline

(-)-Vindoline Use and Manufacturing

A novel antitumor agent Vendolin has antibacterial, anti-inflammatory and anti-cancer effects; a monomeric vinblastine, which exhibits anti-mitotic activity by inhibiting the assembly of microtubules.

Computed Properties

Molecular Weight:456.5
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:456.22603674
Monoisotopic Mass:456.22603674
Topological Polar Surface Area:88.5
Heavy Atom Count:33
Complexity:864
Defined Atom Stereocenter Count:5
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of (-)-Vindoline

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Vindoline

CAS No.: 2182-14-1

Content: 99.00%

Inquiry
Wuhan Pnq Int Trade Co., Ltd Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of Apigenin,PQQ,NMNH

Herbal extract manufacture PNQ supply vindoline

Unit Price: $10-12 /UNIT FOB

CAS No.: 2182-14-1

Grade: Chemical Grade

Content: 99%

Inquiry

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Guide of (-)-Vindoline

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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(-)-Vindoline

SDS

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