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Thiazolidinedione

Thiazolidinedione structure

CAS No:
2295-31-0
Formula:
C3H3NO2S
Chemical Name:
Thiazolidinedione
Synonyms:
2,4-Thiazolidinedione;Thiazolidinedione;2-Thiazolin-4-one,2-hydroxy-;2,4-Dioxothiazolidine;2,4(3H,5H)-Thiazoledione;U 25560;NSC 6745;Thiazole-2,4-dione;2,4-Dioxo-1,3-thiazolidine;Thiazolidin-2,4-dione;2-Hydroxy-4,5-dihydro-1,3-thiazol-4-one
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

White to Off-White Powder

1,3-thiazolidine-2,4-dione is a thiazolidenedione carrying oxo substituents at positions 2 and 4. It derives from a hydride of a 1,3-thiazolidine.|Thiazolidinedione has been investigated for the treatment of Type 2 Diabetes, Diabetes Mellitus, and DIABETES MELLITUS, TYPE 2.

Thiazolidinedione Basic Attributes

Molecular Weight：

117.122

Exact Mass：

117.13

EC Number：

218-941-2

UNII：

AA68LXK93C

NSC Number：

6745

DSSTox ID：

DTXSID5040623

HScode：

2934999090

Characteristics

PSA：

71.5

XLogP3：

0.1

Appearance：

White to Off-White Powder

Density：

1.5±0.1 g/cm3

Melting Point：

128 °C

Boiling Point：

305.7°C at 760 mmHg

Flash Point：

138.7±19.3 °C

Refractive Index：

1.577

Water Solubility：

Soluble in water (30 mg/ml at 3°C), methanol, DMSO, ethanol, and ethyl ether.

Storage Conditions：

Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Vapor Pressure：

0.000809mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R36/37/38

safety instructions：

S24/25

RTECS Number：

XJ5775000

Marks：

Xi: Irritant;

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (70%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 14 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Substances which lower blood glucose levels. (See all compounds classified as Hypoglycemic Agents.)

MeSH Entry Terms：

2,4-thiazolidinedione

Thiazolidinedione Use and Manufacturing

Uses

Inhibitor of enzyme

Manufacturing Info：

2,4-Thiazolidinedione: ACTIVE

Computed Properties

Molecular Weight:117.13
XLogP3:0.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:116.98844951
Monoisotopic Mass:116.98844951
Topological Polar Surface Area:71.5
Heavy Atom Count:7
Complexity:122
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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High purity 2,4-thiazolidedione CAS 2295-31-0

CAS No.: 2295-31-0

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