7,4′-Dihydroxyflavone
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7,4′-Dihydroxyflavone
structure -
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CAS No:
2196-14-7
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Formula:
C15H10O4
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Chemical Name:
7,4′-Dihydroxyflavone
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Synonyms:
4H-1-Benzopyran-4-one,7-hydroxy-2-(4-hydroxyphenyl)-;Flavone,4′,7-dihydroxy-;7-Hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;7,4′-Dihydroxyflavone;4′,7-Dihydroxyflavone;7-Hydroxy-2-(4-Hydroxyphenyl)chromen-4-one;Kumatakenin B;7-Hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
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CAS No:
Description
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NC
4',7-dihydroxyflavone is a dihydroxyflavone in which the two hydroxy substituents are located at positions 4' and 7. It has a role as a metabolite.
Characteristics
66.8
2.54
1.4±0.1 g/cm3
315 °C @ Solvent: Ethanol
512.8±50.0 °C at 760 mmHg
201.2±23.6 °C
1.699
153.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
7,4′-Dihydroxyflavone Use and Manufacturing
Polyketides [PK] -> Flavonoids [PK12] -> Flavones and Flavonols [PK1211]
Computed Properties
Molecular Weight:254.24
XLogP3:3.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:254.05790880
Monoisotopic Mass:254.05790880
Topological Polar Surface Area:66.8
Heavy Atom Count:19
Complexity:382
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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