Sinensetin
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Sinensetin
structure -
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CAS No:
2306-27-6
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Formula:
C20H20O7
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Chemical Name:
Sinensetin
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Synonyms:
4H-1-Benzopyran-4-one,2-(3,4-dimethoxyphenyl)-5,6,7-trimethoxy-;Flavone,3′,4′,5,6,7-pentamethoxy-;Sinensetin;2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one;5,6,7,3′,4′-Pentamethoxyflavone;3′,4′,5,6,7-Pentamethoxyflavone;Pedalitin permethyl ether;5,6,7,3′,4′-Pentamethoxyl flavone;2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-chromen-4-one;2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxychromen-4-one;27181-91-5
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CAS No:
Description
Sinensetin is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.In vitro: Sinensetin promots adipogenesis in 3T3-L1 preadipocytes growing in incomplete differentiation medium, sinensetin enhances adipogenesis and lipolysis by increasing cAMP levels. [1] Sinensetin shows anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α). [2]In vivo: Sinensetin has the
Solid
Sinensetin is a pentamethoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 3' and 4' respectively. It has a role as a plant metabolite. It derives from a flavone.
Characteristics
72.4
3
white to beige
1.2±0.1 g/cm3
142-143 °C
547.8ºC at 760 mmHg
240.6±30.2 °C
1.566
DMSO: soluble 3mg/mL, clear (warmed)
2-8°C
4.73E-12mmHg at 25°C
186.4 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
UN 2811 6.1 / PGIII
3
25
22-24/25-45
T
P301 + P310
H301
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 41 companies from 2 notifications to the ECHA C&L Inventory.
Sinensetin Use and Manufacturing
Sinensetin exhibits anti-fungal, anti-histamine activity; induce cell differentiation, inhibition of linoleic acid oxidation, inhibition of white blood cells in the human zona protein Interleukin -1-induced expression of tissue factor.
Polyketides [PK] -> Flavonoids [PK12] -> Flavones and Flavonols [PK1211]
Computed Properties
Molecular Weight:372.4
XLogP3:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:372.12090297
Monoisotopic Mass:372.12090297
Topological Polar Surface Area:72.4
Heavy Atom Count:27
Complexity:548
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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