Hydrocortisone hemisuccinate
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Hydrocortisone hemisuccinate
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CAS No:
2203-97-6
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Formula:
C25H34O8
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Chemical Name:
Hydrocortisone hemisuccinate
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Synonyms:
Pregn-4-ene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-,(11β)-;Cortisol,21-(hydrogen succinate);Cortisol,hydrogen succinate;(11β)-21-(3-Carboxy-1-oxopropoxy)-11,17-dihydroxypregn-4-ene-3,20-dione;Cortisol 21-hemisuccinate;Hydrocortisone 21-hemisuccinate;Hydrocortisone 21-(hydrogen succinate);Hydrocortisone 21-succinate;Hydrocortisone hemisuccinate;Cortisol hemisuccinate;Hydrocortisone succinate;Cortisol succinate;Hydrocortisone hydrogen succinate;Saxizon;NSC 7576;Hydrocortisone 21-O-β-carbonylpropionic acid;30210-46-9;53623-76-0
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CAS No:
Description
White or almost white, hygroscopic powder
Hydrocortisone succinate is a derivative of succinic acid in which one of the carboxy groups is esterified by the C-21 hydroxy group of cortisol (hydrocortisone). It is a dicarboxylic acid monoester, a hemisuccinate and a tertiary alpha-hydroxy ketone. It derives from a cortisol.
Characteristics
138.20000
2.13
1.3±0.1 g/cm3
170-172 °C
685.5±55.0 °C at 760 mmHg
231.1±25.0 °C
1.587
−20°C
212.4 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
NONH for all modes of transport
3
22-24/25
TU5010147
|Warning|H302 (20%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P314, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 8 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Danger|H360 (70.59%): May damage fertility or the unborn child [Danger Reproductive toxicity]|P201, P202, P260, P281, P308+P313, P314, P405, and P501|Aggregated GHS information provided by 36 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)
A-hyrocort
Hydrocortisone hemisuccinate Use and Manufacturing
glucocorticoid
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Lipids -> Sterol Lipids [ST] -> Steroids [ST02] -> C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives [ST0203]
Computed Properties
Molecular Weight:462.5
XLogP3:1.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:7
Exact Mass:462.22536804
Monoisotopic Mass:462.22536804
Topological Polar Surface Area:138
Heavy Atom Count:33
Complexity:908
Defined Atom Stereocenter Count:7
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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