2-AMINO-5-FLUOROACETOPHENONE
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2-AMINO-5-FLUOROACETOPHENONE
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CAS No:
2343-25-1
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Formula:
C8H8FNO
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Chemical Name:
2-AMINO-5-FLUOROACETOPHENONE
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Synonyms:
1-(2-Amino-5-fluorophenyl)ethanone;2-amino-5-fluoroacetophenone;Ethanone, 1-(2-amino-5-fluorophenyl)-;C8H8FNO;1-(2-Amino-5-fluorophenyl)ethan-1-one;5-Fluor-2-amino-acetophenon;5-fluoro-2-amino-acetophenone;2"-Amino-5"-fluoroacetophenone;SCHEMBL9665493;CTK0I7944
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CAS No:
Characteristics
43.1
1.9
1.2±0.1 g/cm3
64-65 °C
264.232ºC at 760 mmHg
113.6±21.8 °C
1.548
0.01mmHg at 25°C
2-AMINO-5-FLUOROACETOPHENONE Use and Manufacturing
To a solution of compound 3 (5 g, 0.037 mol) in 50 ml_ of THF was added asolution of MeMgBr (50 ml_, 0.147 mol) dropwise at 0°C. After addition, themixture was heated to reflux for 4 hours. The mixture was quenched by additionof 10percent HCI, heated to reflux for another 1hour. The resulting mixture was extracted with EtOAc, washed with brine. Thesolvent was evaporated and the residue was purified with chromatography onsilica gel to afford compound 3a (2.8 g, yield: 50percent).To a solution of compound 3a (1 g, 6.54 mmol) in 10 mL of AcOH was added KNCO(2.65 g, 0.033 mol), then the mixture was kept at room temperature for 30 minthen heated to 60°C overnight. H
Computed Properties
Molecular Weight:153.15
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:153.058992041
Monoisotopic Mass:153.058992041
Topological Polar Surface Area:43.1
Heavy Atom Count:11
Complexity:160
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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