Phenylthiourea

152.22

152.22

907309

203-151-2

6F82C6Q54C

5779

2811|2767

DTXSID9021134

Needles from water; prisms from alcohol|Needles

29309090

70.1

0.71

Off-white to beige Crystalline Powder

1.3 g/cm³

154 °C

266.7±23.0 °C(Predicted)

115.1±22.6 °C

1.5500 (estimate)

soluble in hot water and alcohol.soluble in alcohol

Poison room

2.8X10-4 mm Hg at 25 deg C (est)

LD50 in rats, rabbits (mg/kg): 3, 40 orally (Scheline)

Bitter or tasteless ... depending upon heredity of taster

Henry's Law constant = 8.7X10-8 atm-cu m/mol at 25 °C (est)

pKa = 9.62 (est)

Hydroxyl radical reaction rate constant = 6.37X10-11 cu cm/molec-sec at 25 °C (est)

Insoluble in water.

Amides and Imides

PHENYLTHIOUREA is incompatible with strong oxidizers, strong acids and strong bases. It emits toxic fumes on contact with acid fumes. (NTP, 1992)

I

6.1

UN 2811 6.1/PG 1

3

28-43

28-36/37-45

YU1400000

T+

Stable. Incompatible with strong acids, strong oxidizing agents, strong bases.

P264-P280-P301 + P310

H300-H317

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number P093, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.|A potential candidate for rotary kiln incineration at a temperature range of 820 to 1600 °C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquidsand gases, and longer for solids.|Waste treatment methods. Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging: Dispose of as unused product.

... On contact with acid or acid fumes, it emits highly toxic fumes of sulfoxides and nitroxides.|Incompatible materials: Strong oxidizing agents, strong acids, strong bases.

DHEW/NCI; Bioassay of 1-Phenyl-2-thiourea for Possible Carcinogenicity (1978) Technical Rpt Series No. 148 DHEW Pub No. (NIH) 78-1704

Dangerous disaster hazard; emits toxic fumes of oxides of sulfur and nitrogen when heated to decomposition. Avoid acids or acid fumes. (EPA, 1998)

|Danger|H300 (98.65%): Fatal if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P272, P280, P301+P310, P302+P352, P321, P330, P333+P313, P363, P405, and P501|Aggregated GHS information provided by 77 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H300: Fatal if swallowed [Danger Acute toxicity, oral]

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Avoid inhalation or contact with skin. (EPA, 1998)

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)|Eye/face protection: Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).|Skin protection: Handle with gloves.|Body Protection: Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.|Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.|Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Special hazards arising from the substance or mixture: Carbon oxides, nitrogen oxides (NOx), sulphur oxides.

Spillages often occur in storage and repacking rooms, and they must be cleaned up with care. /Pesticides/|Accidental Release Measures. Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

... Eating, drinking and smoking should be prohibited /when pesticides are being handled./|Precautions for safe handling: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection.|Appropriate engineering controls: Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.|Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.|SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

P093; An acute hazardous waste when a discarded commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).|Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Phenylthiourea is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 100 or 10,000 lbs. Extremely hazardous substances that are solids are subject to either of two threshold planning quantities ... The lower quantity applies only if the solid exists in powdered form and has a particle size less than 100 microns; or is handled in solution or in molten form; or meets the criteria for a National Fire Protection Association (NFPA) rating of 2, 3 or 4 for reactivity. If the solid does not meet any of these criteria, it is subject to the upper ... threshold planning quantity ... .

P093; As stipulated in 40 CFR 261.33, when phenylthiourea, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to federal and/or state hazardous waste regulations. Also defined as a hazardous waste is any container or inner liner used to hold this waste or any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5(e)).

IDENTIFICATION AND USE: 1-Phenyl-2-thiourea is a bitter or tasteless (depending on the individual's genetic background) needle- or prism-like solid material used in medical genetics studies, as a repellent for rats, rabbits, and weasels, and in the production of rodenticides. HUMAN EXPOSURE AND TOXICITY: 1-Phenyl-2-thiourea can be absorbed by ingestion and parenterally; it may be absorbed and cause systemic toxicity following inhalation or dermal exposure. The bitter taste perception (associated with the ability or inability to taste 1-phenyl-2-thiourea) is mediated by the tas2r38 gene. Some studies have found higher proportions of nontasters among those with a family history of alcoholism than controls, whereas others have not. ANIMAL STUDIES: Vomiting, noisy or difficult breathing, cyanosis, and hypothermia may occur. Pleural effusions and pulmonary edema have been seen in exposed experimental animals, and this compound destroys cytochrome P450 in vivo. Hypoglycemia lasting for up to 5 hours was seen in rats injected with 1-phenyl-2-thiourea. In mice it was nearly as effective as a strong dose of licl in reducing sucrose drinking. 1-Phenyl-2-thiourea produced a concn-dependent inhibition of rat lung acetylcholinesterase activity in vitro. Phenylthiourea caused mutagenicity in the Salmonella typhimurium assay without S9 activation, but was negative in the salmonella/microsome preincubation assay. At the standard concentration of 0.003% (200 uM), 1-phenyl-2-thiourea inhibits melanogenesis and reportedly has minimal other effects on zebrafish embryogenesis. The administration of 0.003% 1-phenyl-2-thiourea altered retinoic acid and insulin-like growth factor regulation of neural crest and mesodermal components of craniofacial development. 1-Phenyl-2-thiourea also decreased retinoic acid-induced teratogenic effects on pharyngeal arch and jaw cartilage despite morphologically normal appearing 1-phenyl-2-thiourea -treated controls. 1-Phenyl-2-thiourea inhibited neural crest development at higher concentrations (0.03%) and had the greatest inhibitory effect when added prior to 22 hours post fertilization (hpf). Addition of 0.003% 1-phenyl-2-thiourea between 4 and 20 hpf decreased thyroxine (T4) in thyroid follicles in the nasopharynx of 96 hpf embryos. 1-Phenyl-2-thiourea is an experimental teratogen in mice. In NTP 78 weeks feeding study 1-phenyl-2-thiourea was not carcinogenic to rats (120 and 60 ppm) and mice (300 and 150 ppm) in both males or females.

The present study examined the combined effect of dopamine and 1-methyl-4-phenylpyridinium (MPP(+)) on the membrane permeability in isolated brain mitochondria and on cell viability in PC12 cells. MPP(+) increased effect of dopamine against the swelling, membrane potential, and Ca(2+) transport in isolated mitochondria, which was not inhibited by the addition of antioxidant enzymes (SOD and catalase). Dopamine or MPP(+) caused the decrease in transmembrane potential, increase in reactive oxygen species, depletion of GSH, and cell death in PC12 cells. Antioxidant enzymes reduced each effect of dopamine and MPP(+) against PC12 cells. Co-addition of dopamine and MPP(+) caused the decrease in the transmembrane potential and increase in the formation of reactive oxygen species in PC12 cells, in which they showed an additive effect. Dopamine plus MPP(+)-induced the depletion of GSH and cell death in PC12 cells were not decreased by the addition of antioxidant enzymes, rutin, diethylstilbestrol, and ascorbate. Melanin caused a cell viability loss in PC12 cells. The N-acetylcysteine, N-phenylthiourea, and 5-hydroxyindole decreased the cell death and the formation of dopamine quinone and melanin induced by co-addition of dopamine and MPP(+), whereas deprenyl and chlorgyline did not show an inhibitory effect. The results suggest that co-addition of dopamine and MPP(+) shows an enhancing effect on the change in mitochondrial membrane permeability and cell death, which may be accomplished by toxic quinone and melanin derived from the MPP(+)-stimulated dopamine oxidation.|Pretreatment of animals with 1-methyl-1-phenylthiourea prevents desulfuration & reduces toxicity of PTU.|Cysteine & reduced glutathione partially reduced the liver glycogen-depleting effect of a toxic phenylthiourea dose in rats.|In vitro binding of (14)Carbon thiourea to rat lung protein was antagonized by the presence of phenylthiourea.|For more Interactions (Complete) data for 1-PHENYL-2-THIOUREA (7 total), please visit the HSDB record page.

LD50 Rat oral 3 mg/kg|LD50 Rabbit oral 40 mg/kg|LD50 Rat ip 5 mg/kg|LD50 Mouse oral 10 mg/kg|LD50 Mouse ip 25 mg/kg

A bioassay of 1-phenyl-2-thiourea for possible carcinogenicity was conducted using Fischer 344 rats and B6C3F1 mice. 1-Phenyl-2-thiourea was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. The high and low concentrations of 1-phenyl-2-thiourea utilized in the chronic studies were, respectively, 120 and 60 ppm for rats and 300 and 150 ppm for mice. Twenty animals of each species and sex were placed on test as controls. A 78 wk period of chemical administration was followed by an additional observation period of 26 wk for rats and 13 wk for mice. ... There were no tumors in either sex of rats or mice for which a significant positive association could be established between chemical administration and tumor incidence. Under the conditions of this bioassay, 1-phenyl-2-thiourea was not carcinogenic to Fischer 344 rats or B6C3F1 mice.

1-Phenyl-2-thiourea's production and use in medical genetics(1) and as an ingredient in silver polishes may result in its release to the environment through various waste streams(SRC). It's limited use as an inert ingredient in residential pesticides(2) will result in its direct release to the environment(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 100(SRC), determined from a structure estimation method(2), indicates that 1-phenyl-2-thiourea is expected to have high mobility in soil(SRC). The estimated pKa of 1-phenyl-2-thiourea is 9.62(3), indicating that this compound will exist partially in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of the anion form of 1-phenyl-2-thiourea from moist soil surfaces is not expected because anions do not volatilize(SRC). Volatilization of neutral 1-phenyl-2-thiourea from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 8.7X10-8 atm-cu m/mole(SRC), using a fragment constant estimation method(2). 1-Phenyl-2-thiourea is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.8X10-4 mm Hg at 25 °C(SRC), determined from a fragment constant method(2). Biodegradation data in soil were not available(SRC, 2014).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 100(SRC), determined from a structure estimation method(2), indicates that 1-phenyl-2-thiourea is expected to adsorb to suspended solids and sediment(SRC). An estimated pKa of 9.62(3) indicates 1-phenyl-2-thiourea will exist partially in the anion form at pH values of 5 to 9 and, therefore, volatilization of the anion form from water surfaces is not expected to be an important fate process(SRC). Volatilization of the neutral form from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 8.7X10-8 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). 1-Phenyl-2-thiourea is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of 0.71(6) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation data in water were not available(SRC, 2014).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-phenyl-2-thiourea, which has an estimated vapor pressure of 2.8X10-4 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-phenyl-2-thiourea is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5 hours(SRC), calculated from its rate constant of 6.3X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). 1-Phenyl-2-thiourea contains chromophores that absorb at wavelengths >290 nm(3) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of 1-phenyl-2-thiourea with photochemically-produced hydroxyl radicals has been estimated as 6.4X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 5 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 1-Phenyl-2-thiourea is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). 1-Phenyl-2-thiourea contains chromophores that absorb at wavelengths >290 nm(2) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 3 was calculated in fish for 1-phenyl-2-thiourea(SRC), using a log Kow of 0.71(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 1-phenyl-2-thiourea can be estimated to be 100(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1-phenyl-2-thiourea is expected to have high mobility in soil. The estimated pKa of 1-phenyl-2-thiourea is 9.62(3), indicating that this compound will exist partially in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).

An estimated pKa of 9.62(1) indicates 1-phenyl-2-thiourea will exist partially in the anion form at pH values of 5 to 9 and, therefore, volatilization of the ionic form from water and moist surfaces is not expected to be an important fate process(SRC). The Henry's Law constant for 1-phenyl-2-thiourea is estimated as 8.7X10-8 atm-cu m/mole(SRC) using a fragment constant estimation method(2). This Henry's Law constant indicates that neutral 1-phenyl-2-thiourea is expected to be essentially nonvolatile from water and moist soil surfaces(3). 1-Phenyl-2-thiourea is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.8X10-4 mm Hg(SRC), determined from a fragment constant method(2).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 2415 workers (483 of these were female) were potentially exposed to 1-phenyl-2-thiourea in the US(1). Occupational exposure to 1-phenyl-2-thiourea may occur through inhalation and dermal contact with this compound at at workplaces where 1-phenyl-2-thiourea is produced or used(SRC). Limited use data indicate that the general population may be exposed to 1-phenyl-2-thiourea via dermal contact with consumer products containing this compound(SRC).

Extensively metabolized in rabbits & 86% excreted in urine over 2 days with addnl 10% in feces. Desulfuration of the molecule is extensive, & the sulfur label is excreted more slowly. Eventually 60% is recovered as urinary sulfate.|After admin of (35)Sulfur-cmpd to ... /rats & rabbits/ excretion of (35)Sulfur was slower compared to that of (14)Carbon after (14)Carbon-cmpd. ... /Results/ indicated that desulfuration of 1-phenyl-2-thiourea occurred in vivo & ... suggested that some hydrogen sulfide was liberated ... & may be responsible for toxic effects ... 2 hr after ip admin of (35)Sulfur-cmpd to rats, levels of (35)Sulfur were high in organs of biotransformation & excretion (liver & kidneys) & also in lung & thyroid gland, organs affected by 1-phenyl-2-thiourea.

Yields aniline, p-hydroxyphenylthiourea, phenylcyanamide, & phenylurea in rabbit. /From table/|... Investigated S-oxidation of N-substituted thioureas by purified hog liver mixed-function amine oxidase and pig and hamster liver microsomal fractions. In the presence of enzyme, O2, and nicotinamide adenine dinucleotide phosphate reductase, phenylthiourea ... metabolized to the corresponding formamidine sulfinic acid ... reaction ... occurred through intermediary sulfenic acids, indicating two consecutive oxidations. The formamidine sulfinic acid products then auto-oxidized slowly to the corresponding sulfonic acids.

Thyroid hormone (T4) can be detected in thyroid follicles in wild-type zebrafish larvae from 3 days of development, when the thyroid has differentiated. In contrast, embryos or larvae treated with goitrogens (substances such as methimazole, potassium percholorate, and 6-n-propyl-2-thiouracil) are devoid of thyroid hormone immunoreactivity. Phenythiourea (PTurea; also commonly known as PTU) is widely used in zebrafish research to suppress pigmentation in developing embryos/fry. PTurea contains a thiocarbamide group that is responsible for goitrogenic activity in methimazole and 6-n-propyl-2-thiouracil. In the present study, /this research/ shows that commonly used doses of 0.003% PTurea abolish T4 immunoreactivity of the thyroid follicles of zebrafish larvae. As development of the thyroid gland is not affected, these data suggest that PTurea blocks thyroid hormone production. Like other goitrogens, PTurea causes delayed hatching, retardation and malformation of embryos or larvae with increasing doses. At doses of 0.003% PTurea, however, toxic side effects seem to be at a minimum, and the maternal contribution of the hormone might compensate for compromised thyroid function during the first days of development.|The ability or inability to taste the compound phenylthiocarbamide (PTC) is a classic inherited trait in humans and has been the subject of genetic and anthropological studies for over 70 years. This trait has also been shown to correlate with a number of dietary preferences and thus may have important implications for human health. The recent identification of the gene that underlies this phenotype has produced several surprising findings. This gene is a member of the T2R family of bitter taste receptor genes. It exists in seven different allelic forms, although only two of these, designated the major taster and major non-taster forms, exist at high frequency outside sub-Saharan Africa. The non-taster allele resides on a small chromosomal region identical by descent, indicating that non-tasters are descended from an ancient founder individual, and consistent with an origin of the non-taster allele preceding the emergence of modern humans out of Africa. The two major forms differ from each other at three amino acid positions, and both alleles have been maintained at high frequency by balancing natural selection, suggesting that the non-taster allele serves some function. We hypothesize that this function is to serve as a receptor for another, as yet unidentified toxic bitter substance. At least some of the remaining five haplotypes appear to confer intermediate sensitivity to PTC, suggesting future detailed studies of the relationships between receptor structure and taste function.|Humans' bitter taste perception is mediated by the hTAS2R subfamily of the G protein-coupled membrane receptors (GPCRs). Structural information on these receptors is currently limited. Here we identify residues involved in the binding of phenylthiocarbamide (PTC) and in receptor activation in one of the most widely studied hTAS2Rs (hTAS2R38) by means of structural bioinformatics and molecular docking. The predictions are validated by site-directed mutagenesis experiments that involve specific residues located in the putative binding site and trans-membrane (TM) helices 6 and 7 putatively involved in receptor activation. Based on our measurements, we suggest that (i) residue N103 participates actively in PTC binding, in line with previous computational studies. (ii) W99, M100 and S259 contribute to define the size and shape of the binding cavity. (iii) W99 and M100, along with F255 and V296, play a key role for receptor activation, providing insights on bitter taste receptor activation not emerging from the previously reported computational models.

It is classified as extremely toxic. The probable oral lethal dose is 5-50 mg/kg or between 7 drops and 1 teaspoon for a 70 kg (150 lb.) person. (EPA, 1998)

Signs and Symptoms of Phenylthiourea Exposure: Acute exposure to phenylthiourea may result in vomiting, difficult breathing, noisy breathing, cyanosis, and low body temperature. Antithyroid activity and hyperglycemia may be observed after chronic sublethal exposure. Emergency Life-Support Procedures: Acute exposure to phenylthiourea may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to phenylthiourea. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Rush to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel shouldavoid self-exposure to phenylthiourea. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas twice with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Rush to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of phenylthiourea is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should not be administered to children under6 months of age. Warning: Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step 4.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be re-administered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2oz) is recommended for adults. 6. Rush to a health care facility. (EPA, 1998)

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/amines and related compounds/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/amines and related compounds/|/SRP:/Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W TKO /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/amines and related compounds/

/SIGNS AND SYMPTOMS/ Information profiles were presented for thiourea and the following thiourea compounds considered important in the industrial community: 1-allyl-3-(2-hydroxyethyl)-2-thiourea (105817), allylthiourea (109579), N,N'-bis(hydroxymethyl)thiourea (3084251), N,N'-bis(methoxymethyl)thiourea (51872265), 1-butyl-3-ethyl-2-thiourea (32900064), 1,3-dibutyl-2-thiourea (109466), 1,3-diisopropyl-2-thiourea (2986176), 1,3-dimethyl-2-thiourea (534134), N,N'-di-o-tolylthiourea (137973), 3-ethyl-1,1-dimethyl-2-thiourea (15361861), ethylthiourea (625536), (hydroxymethyl)thiourea (1000835), (2-methylphenyl)thiourea (614788), thiourea (62566), 1,3-diethyl-2-thiourea (105555), 1,3-diphenyl-2-thiourea (102089), ethylenethiourea (96457), 1-naphthylthiourea (86884), 1-phenyl-2-thiourea (103855), 1,1,3,3-tetramethylthiourea (2782914) and 1,1,3-trimethyl-2-thiourea (2489772)... Positive mutagenic effects have been elicited in various assays with several of these compounds. The use of thiourea, diethylthiourea and tetramethylthiourea as antithyroid drugs indicated these compounds have antithyroidal effects in humans. Frequently observed side effects from the use of these medications have included headache, anxiety, fever, skin rash, and gastrointestinal disturbances. /thioureas/|/SIGNS AND SYMPTOMS/ In the manufacture of rubber, irritant contact dermatitis may occur from a variety of acids, alkalis, detergents, and solvents used in the process. Allergic contact dermatitis occurs not infrequently and is almost always due to an organic accelerator or antioxidant. While the list of potential sensitizing accelerators and antioxidants is enormous, common allergens include ... thioureas. /Thioureas/|/EPIDEMIOLOGY STUDIES/ The bitter taste perception (associated with the ability or inability to taste phenylthiocarbamide) is mediated by the TAS2R38 gene. Most of the variation in this gene is explained by three common amino-acid polymorphisms at positions 49 (encoding proline or alanine), 262 (alanine or valine) and 296 (valine or isoleucine) that determine two common isoforms: proline-alanine-valine (PAV) and alanine-valine-isoleucine (AVI). PAV is the major taster haplotype (heterozygote and homozygote) and AVI is the major non-taster haplotype (homozygote). Amino acid 49 has the major effect on the distinction between tasters and non-tasters of all three variants. The sense of bitter taste protects us from ingesting toxic substances, present in some vegetables, that can affect the thyroid when ingested in large quantities. Balancing selection has been used to explain the current high non-taster frequency, by maintaining divergent TAS2R38 alleles in humans. /Researchers/ have amplified and sequenced the TAS2R38 amino acid 49 in the virtually uncontaminated Neanderthal sample of El Sidron 1253 and have determined that it was heterozygous. Thus, this Neanderthal was a taster individual, although probably slightly less than a PAV homozygote. This indicates that variation in bitter taste perception pre-dates the divergence of the lineages leading to Neanderthals and modern humans.|/EPIDEMIOLOGY STUDIES/ Test strips impregnated with phenylthiocarbamide (PTC) have been used to identify genetic differences based on whether a bitter taste is perceived. To determine whether smokers who perceive PTC as bitter tasting ("tasters") would differ from those who describe it as tasteless ("non-tasters") on smoking-related variables, /this research/ studied 464 current smokers (70% female, 79% White; mean age 30.5+/-9 years) recruited to participate in laboratory experiments and clinical trials. Of these, 217 (47%) reported the PTC strips as tasteless and 154 (33%) as tasting bitter. The remaining 93 (20%) described the taste as salty, sweet, or other and were excluded from further analyses. Comparing tasters with non-tasters, /this research/ found significant differences in mean (S.D.) total years smoked (14.5 [9.2] for non-tasters, vs. 12.6 [8.4] for tasters, p<.05), Fagerstrom Tolerance Questionnaire scores (6.4 [2.1] vs. 5.8 [2.1], p<.01), and scores on the Positive Reinforcement scale of the Michigan-Nicotine Reinforcement Questionnaire (8.1 [2.9] vs. 6.8 [3.1], p<.05). Results suggest that among smokers, ability to taste PTC may confer some protection from development of nicotine dependence and positive reinforcement from smoking.|For more Human Toxicity Excerpts (Complete) data for 1-PHENYL-2-THIOUREA (9 total), please visit the HSDB record page.

Phenylthiocarbamide

Thiourea, N-phenyl-: ACTIVE|Phenylthiourea is a repellent for rats, rabbits, and weasels. Effective concn are 0.012-0.014%, & can be lowered to 0.002-0.003% by addition of 5% sucrose.

Polarographic behavior of phenylthiourea in Britton-Robinson buffer & sodium hydroxide solutions was investigated. Differential pulse voltammetry was used to resolve a mixt containing phenylthiourea. This technique can be used to determine concn down to 0.1 uM.