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Periciazine

Periciazine structure

CAS No:
2622-26-6
Formula:
C21H23N3OS
Chemical Name:
Periciazine
Synonyms:
10H-Phenothiazine-2-carbonitrile,10-[3-(4-hydroxy-1-piperidinyl)propyl]-;Phenothiazine-2-carbonitrile,10-[3-(4-hydroxypiperidino)propyl]-;10-[3-(4-Hydroxy-1-piperidinyl)propyl]-10H-phenothiazine-2-carbonitrile;FI 6145;RP 8909;2-Cyano-10-[3-(4-hydroxy-1-piperidyl)propyl]phenothiazine;10-[3-(4-Hydroxypiperidino)propyl]phenothiazine-2-carbonitrile;Neulactil;Neuleptil;Periciazine;Pericyazine;Propericiazine;2-Cyano-10-[3-(4-hydroxypiperidino)propyl]phenothiazine;Aolept;Periciazinum;Bayer 1409;Nemactil;Properciazine;Nelactil;SKF 20716;Propericyazine;47476-90-4
Categories:
Chemical Reagents > Organic Reagents

Description

Pericyazine (Propericiazine) is a first-generation antipsychotic drug that is used as an adjunct to the short-term management of severe anxiety states and psychosis[1]. Pericyazine (Propericiazine) is a selective D2-dopamine receptor antagonist[2][3].

Solid

Periciazine is a member of the class of phenothiazines that is 10H-phenothiazine substituted by a 3-(4-hydroxypiperidin-1-yl)propyl group at the nitrogen atom and a carbonitrile group at position 2. Periciazine is a first generation antipsychotic. It has a role as a sedative, an adrenergic antagonist and a first generation antipsychotic. It is a nitrile, a member of phenothiazines and a hydroxypiperidine. It derives from a hydride of a 10H-phenothiazine.|Periciazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic and endocrine effects and an action on the extrapyramidal system. It is used as an adjunctive medication in some psychotic patients, for the control of residual prevailing hostility, impulsiveness and aggressiveness. Pericyazine, like other phenothiazines, is presumed to act principally in the subcortical areas, by producing what has been described as a central adrenergic blockade.

Periciazine Basic Attributes

Molecular Weight：

365.492

Exact Mass：

365.49

EC Number：

220-071-3

UNII：

3405M6FD73

NSC Number：

758641

DSSTox ID：

DTXSID5045910

ATC Code：

N - Nervous system

HScode：

2934300000

Characteristics

PSA：

75.80000

XLogP3：

3.76

Appearance：

Solid

Density：

1.3±0.1 g/cm3

Melting Point：

116-117 °C

Boiling Point：

593.4±50.0 °C at 760 mmHg

Flash Point：

312.7±30.1 °C

Refractive Index：

1.694

Water Solubility：

38.01mg/L(37 ºC)

Storage Conditions：

2-8ºC

Vapor Pressure：

6.29E-15mmHg at 25°C

Toxicity：

LD50 orally in rats: 395 mg/kg (Schafer)

Collision Cross Section：

186.4 Å² [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]|186.6 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

hazard class code：

R22

safety instructions：

26-36

Marks：

Xn: Harmful;

Precautionary statement(s)：

P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P321, P322, P330, P333+P313, P363, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P321, P322, P330, P333+P313, P363, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity Summary：

In milder cases of phenothiazine overdosage the patient may be agitated, delirious and confused. Frequently he is lethargic or in a comatose state. Twitching, dystonic movements or convulsions may be present and hypotension, cardiovascular collapse, arrhythmias and hypothermia might be observed.

Drug Information

Drug Indication：

For use as adjunctive medication in some psychotic patients. Propericiazine (Pericyazine)is used for the control of residual prevailing hostility, impulsiveness and aggressiveness.

Pharmacology：

Pericyazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic and endocrine effects, and an action on the extrapyramidal system.

Mechanism of Action：

Pericyazine, like other phenothiazines, is presumed to act principally in the subcortical areas, by producing what has been described as a central adrenergic blockade of the alpha adrenergic receptors as well as antagonism of the D(1) dopamine receptor.

MeSH Entry Terms：

Aolept

Periciazine Use and Manufacturing

Uses

Spectrophotometric reagent for palladium and ruthenium. Psychotherapeutic phenothiazine. Antipsychotic.

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:365.5
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:365.15618354
Monoisotopic Mass:365.15618354
Topological Polar Surface Area:75.8
Heavy Atom Count:26
Complexity:513
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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PROPERICYAZINE, CAS:2622-26-6

Unit Price: $30-35 /KG FOB

CAS No.: 2622-26-6

Grade: Reagent Grade

Content: 99%

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