Chlorphenesin
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Chlorphenesin
structure -
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CAS No:
104-29-0
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Formula:
C9H11ClO3
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Chemical Name:
Chlorphenesin
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Synonyms:
1,2-Propanediol,3-(4-chlorophenoxy)-;1,2-Propanediol,3-(p-chlorophenoxy)-;3-(4-Chlorophenoxy)-1,2-propanediol;Adermykon;p-Chlorophenyl glyceryl ether;p-Chlorophenyl-α-glyceryl ether;Chlorphenesin;Glycerol α-p-chlorophenyl ether;Mycil;3-(p-Chlorophenoxy)propane-1,2-diol;Demykon;Gecophen;p-Chlorphenesin;(±)-Chlorphenesin;(±)-p-Chlorphenesin;Elestab CPN;NSC 6401;1,2-Ethanediol,1-(4-chlorophenoxy)-;62067-20-3;2320573-12-2
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CAS No:
Description
White to Off-White SolidChEBI: Glycerol in which the hydrogen of one of the primary hydroxy groups is substituted by a 4-chlorophenyl group. It has antifungal and antibacterial properties, and is used for treatment of cutaneous and vaginal infections. Its 1-carbamate is used as a skelet l muscle relaxant for the treatment of painful muscle spasm.
Solid
Chlorphenesin is glycerol in which the hydrogen of one of the primary hydroxy groups is substituted by a 4-chlorophenyl group. It has antifungal and antibacterial properties, and is used for treatment of cutaneous and vaginal infections. Its 1-carbamate is used as a skeletal muscle relaxant for the treatment of painful muscle spasm. It has a role as a muscle relaxant, an antibacterial drug and an antifungal drug. It is a glycol, a member of propane-1,2-diols and a member of monochlorobenzenes.|A centrally acting muscle relaxant. Its mode of action is unknown. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1203)
Chlorphenesin Basic Attributes
202.63
202.63
203-192-6
6401
DTXSID0049028
D - Dermatologicals
29094990
Characteristics
49.7
1.2
Solid
1.2411 (rough estimate)
78 °C
290.96°C (rough estimate)
177.2±23.7 °C
1.5470 (estimate)
Slightly soluble in water.
4.13E-06mmHg at 25°C
Safety Information
20/21/22-36/37/38
26-36-37
TY4260000
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501
H302
|Danger|H302 (32.43%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 394 companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Used, along with rest and physical therapy, to treat injuries and other painful muscular conditions. Investigated for use in trigeminal neuralgia (tic douloureux), a neuropathic disorder characterized by severe facial pain. Was investigated as a modulator of histamine release.
Chlorphenesin is a muscle relaxant. It blocks nerve impulses (or pain sensations) that are sent to the brain.
A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) (See all compounds classified as Muscle Relaxants, Central.)
Rapid and complete.
Hepatic. 85% of a dose excreted within 24 hours as the glucuronide metabolite.
2.3-5 hours
The mechanism of action of chlorphenesin is not well defined, and its effects are measured mainly by subjective responses. It is known that chlorphenesin acts in the central nervous system (CNS) rather than directly on skeletal muscle.
Chlorphenesin
Chlorphenesin Use and Manufacturing
Chlorphenesin is an antigen-associated immunosuppressant that inhibits IgE-mediated histamine release. Chlorphenesin is also used as an antimycotic agent.
Cosmetics -> Preservative
Computed Properties
Molecular Weight:202.63
XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:202.0396719
Monoisotopic Mass:202.0396719
Topological Polar Surface Area:49.7
Heavy Atom Count:13
Complexity:135
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Preservative with antimicrobial properties, helps prevent microbial growth in cosmetic formulations
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