4-PYRROLIDIN-1-YLANILINE

General procedure: The nitrophenyl analogue 7a–7e (7.5 mmol) was dissolved in ethanol (50 mL), and to this solution was added 10percent Pd/C (0.2 g). The reaction mixture was stirred at room temperature under an atmosphere of HGeneral procedure: To a solution of 1-(substituted) 4-nitrobenzene IVa, b, e, f(0.01 mol) in NH4OH (20 mL, 30percent), a solution of sodium dithionite(7 g, 0.04 mol) in water (30 mL) was quickly added, the reactionmixture was refluxed for 15 min. After cooling, the crude productwas filtered, washed and crystallized from methylene chloride toyield target compounds Va, b, e, f. 4-(Pyrrolidin-1-yl) aniline Vb 2) The second step: to install a magnetic stir, thermometer, condenser 500mL three-necked flask is addedThe first step in the reaction of 10.0g of 4-nitrophenyl pyrrolidine powder, 1.5g of 10percent mass fraction ofPd / C, was added 150mL ethanol as a solvent, to give a uniform suspension with stirring. After heating to reflux, The suspension was slowly added dropwise 32.0g mass fraction of 80percent hydrazine hydrate, stirring continued at reflux for 12h. ReactionIs completed, the reaction solution was filtered hot to remove Pd / C, the filtrate was concentrated under reduced pressure to 1/4 of its original volume, in a nitrogen atmosphereUnder cooling and crystallization, to give a gray crystalline 4-amino-phenyl pyrrolidine 6.8g, 80percent yield;;

Molecular Weight:162.23
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:162.115698455
Monoisotopic Mass:162.115698455
Topological Polar Surface Area:29.3
Heavy Atom Count:12
Complexity:133
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes