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4-Nitroanisole

4-Nitroanisole structure

4-Nitroanisole 

structure
  • CAS No:

    100-17-4

  • Formula:

    C7H7NO3

  • Chemical Name:

    4-Nitroanisole

  • Synonyms:

    Benzene,1-methoxy-4-nitro-;Anisole,p-nitro-;1-Methoxy-4-nitrobenzene;p-Methoxynitrobenzene;p-Nitroanisole;4-Nitroanisole;4-Methoxynitrobenzene;4-Methoxy-1-nitrobenzene;Methyl p-nitrophenyl ether;p-Nitromethoxybenzene;4-Nitrophenyl methyl ether;4-Nitromethoxybenzene;4-Nitro-1-methoxybenzene;p-Nitrobenzene methyl ether;Methyl 4-nitrophenyl ether;NSC 5507;1-Nitro-4-methoxybenzene;721942-42-3

  • Categories:

    Chemical Reagents  >  Organic Reagents

Description

In the vast sky of chemistry, 4-Nitroanisole is a remarkable presence because of its unique structure and properties. This organic compound, marked by the unique nitro-substituted methoxy group in its molecules, not only shows a charming color of light red or amber in appearance, but also shows many remarkable characteristics in physical and chemical properties. First, from a physical point of view, 4-Nitroanisole is unique among many organic compounds because it is insoluble in water. It is denser than water, which allows us to easily separate it from water in the laboratory by density differences. However, while this substance is beautiful, it also has a certain hidden danger. Because 4-Nitroanisole May irritate the skin, eyes and mucous membranes, and may be toxic to the human body through ingestion, inhalation or skin absorption, we must always be vigilant when operating 4-nitroanisole and take strict safety measures, such as wearing protective glasses, gloves and respirators, to ensure our safety. So where exactly is 4-Nitroanisole used? In fact, this compound plays an important role in many fields such as the chemical industry, pharmaceutical manufacturing, and pesticide production. In the chemical industry, it is often used as a raw material for the synthesis of other complex organics; In the field of pharmaceutical manufacturing, because of its unique chemical properties, it is used to synthesize some compounds with special pharmacological effects; In the production of pesticides, 4-Nitroanisole is widely used in the synthesis of pesticides such as insecticides and herbicides. In order to better understand the toxicity of 4-Nitroanisole and its potential threat to human health, we have to mention some relevant scientific studies. Experiments have shown that long-term exposure to 4-Nitroanisole May lead to a series of health problems, such as skin allergies, respiratory diseases and even nervous system damage. Therefore, it is particularly important for those working with 4-Nitroanisole to have regular health checks, strengthen personal protection and strictly follow the operating procedures. In addition, it is worth mentioning that with the continuous development of science and technology, the research on 4-Nitroanisole is also going deeper and deeper. By using modern analytical techniques and synthetic methods, scientists have not only revealed more of its unknown chemical properties and application potential, but also provided us with more scientific basis for its toxic mechanism and protective strategies. These research results not only help us make better use of 4-Nitroanisole, a valuable resource, but also provide strong support for our own health and safety.

4-Nitroanisole Basic Attributes

153.14

153.14

1865361

202-825-3

2909309090

Characteristics

55

2.03

Green to brown Crystals

1.2083 g/cm3 @ Temp: 68.4 °C

54 °C

274 °C

130 °C

1.5030 (estimate)

H2O: 0.468 g/L (20 ºC)

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

1 mm Hg at 127° F ; 18.5 mm Hg at 167° F; 30.0 mm Hg at 194° F (NTP, 1992)

Oral-rat LD50: 2300 mg/kg;Oral-Mouse LDL0:300 mg/kg

Open flame is flammable; burning releases toxic nitrogen oxide fumes

Safety Information

III

6.1

UN 3458 6.1/PG 3

1

52/53-68

61-36/37

BZ8800000

Xn

Treasury is ventilated at low temperature and dry; stored separately from oxidants and food additives

Stable. Incompatible with strong oxidizing agents, strong bases.

P201, P202, P273, P281, P308+P313, P405, P501

H351

UN 3458

Toxicity

moderately toxic

Name Type of Test Exposure Route Species Observed Dose/Duration Toxic Effects Reference
ACUTE TOXICITY DATA LD50 - Lethal dose, 50 percent kill Oral Rodent - rat 2300 mg/kg Details of toxic effects not reported other than lethal dose value-- Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued. Volume(issue)/page/year: 128,14,1979
ACUTE TOXICITY DATA LD50 - Lethal dose, 50 percent kill Administration onto the skin Rodent - rat >16 gm/kg Liver--fatty liver degeneration
Kidney, Ureter, Bladder--other changes
Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW. Volume(issue)/page/year: 17,217,1959
ACUTE TOXICITY DATA LD50 - Lethal dose, 50 percent kill Intraperitoneal Rodent - rat 1400 mg/kg Behavioral--general anesthetic
Gastrointestinal--other changes
Liver--fatty liver degeneration
Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW. Volume(issue)/page/year: 17,217,1959

4-Nitroanisole Use and Manufacturing

Methods of Manufacturing

By nitrochlorobenzene by methoxylation reaction.

Uses

The name 4-Nitroanisole May seem strange to many people, but it is a shining pearl in the chemical industry, and its application range and role are far beyond the imagination of ordinary people. As a vital organic compound, 4-Nitroanisole shines in many fields with its unique chemical properties, becoming an important bridge between the chemical world and real life. First, let's focus on 4-Nitroanisole's central role in the pharmaceutical industry. In this highly sophisticated and challenging field, the choice of each chemical feedstock is critical. Due to its excellent reactivity and stability, 4-Nitroanisole is a key intermediate in many drug synthesis pathways. Like a behind-the-scenes hero, it silently participates in the construction process of complex drug molecules, contributing its own strength to the treatment of diseases and saving lives. For example, 4-Nitroanisole plays a crucial role in the development of some anti-cancer drugs. Through its unique structural properties, 4-nitroanisole promotes the effective binding of drug molecules with cancer cell targets, thus achieving precise attack on cancer cells. In addition, the field of agricultural chemicals is also a stage for 4-Nitroanisole to show its strength. In modern agriculture, the widespread use of chemicals such as pesticides and fertilizers has greatly improved the yield and quality of crops. As one of the most important synthetic raw materials for these chemicals, 4-Nitroanisole is of great importance. It can not only improve the insecticidal effect of pesticides, but also enhance the utilization rate of fertilizers, providing strong support for agricultural production. By participating in the synthesis process of pesticides and fertilizers, 4-Nitroanisole indirectly contributes to the stability and development of global food production. In addition to the pharmaceutical and agricultural chemicals sector, 4-Nitroanisole also plays an irreplaceable role in the dyes and pigments industry. As an excellent synthetic raw material, it can react with a variety of chemical substances to produce bright colors and strong stability of dyes and pigments. These dyes and pigments are widely used in textile, printing, plastics and other industries, adding rich color and beauty to our lives. The contribution of 4-Nitroanisole, an important raw material, from colorful clothing to exquisite prints, is indispensable. It is worth mentioning that 4-Nitroanisole also plays an important role in the field of organic synthesis. Its good solubility and reactivity make it an ideal choice for many organic synthesis reactions. Whether it is to build a complex organic molecular skeleton or introduce specific functional groups, 4-Nitroanisole can easily cope with its unique chemical properties. Therefore, 4-Nitroanisole also plays a key role in the development of new materials and compounds. It is like a key that opens the door to the world of new materials and provides unlimited possibilities for scientific research and industrial production.

Analysis Methods

Name Column Shape Active Phase(℃) Retention index Temperature Control Method Comments Reference
Van Den Dool and Kratz RI, non-polar column, temperature ramp Capillary VF-5MS 1414. temperature ramp 30. m/0.25 mm/0.25 μm, He; Tstart: 60. C; Tend: 270. C Todua, N.G.Retention Data. NIST Mass Spectrometry Data Center.NIST Mass Spectrometry Data Center, 2011.
Van Den Dool and Kratz RI, non-polar column, temperature ramp Capillary VF-5MS 1424.3 custom temperature program 30. m/0.25 mm/0.25 μm, He; Program: Multi-step temperature program; T(initial)=60C; T(final)=270C Tret'yakov, K.V.Retention Data. NIST Mass Spectrometry Data Center.NIST Mass Spectrometry Data Center, 2007.
Van Den Dool and Kratz RI, non-polar column, temperature ramp Capillary HP-5MS 1463. temperature ramp 30. m/0.25 mm/0.25 μm, Helium, 50. C @ 1. min, 7. K/min, 250. C @ 5. min Zouari, S.Zouari, N.Fakhfakh, N.Bougatel, A.Ayadi, M.A.Neffati, M.Chemical composition and biological activities of a new essential oil chemotype of Tunisian Artemisia herba alba AssoJ. Medicinal Plants Res.2010, 4, 10, 871-880.

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