H-Lys(Boc)-OH
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H-Lys(Boc)-OH
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CAS No:
2418-95-3
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Formula:
C11H22N2O4
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Chemical Name:
H-Lys(Boc)-OH
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Synonyms:
Lys(Boc)-OH;(S)-2-AMino-6-((tert-butoxycarbonyl)aMino)hexanoic acid;L-Lysine,N6-[(1,1-diMethylethoxy)carbonyl]-;H-Lys(Boc)-OH >=95%;Nε-Boc-L-Lysine≥ 98% (HPLC);Ne-Boc-L-lysine Nε-Boc-L-lysine N-epsilon-tert-Butoxycarbonyl-L-lysine;Nepsilon-Boc-L-lysine H-Lys(Boc)-OH;N6-Boc-L-lysine
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CAS No:
Description
white crystalline powder
H-Lys(Boc)-OH, also known as H-Lys(t-BOC)-OH, is an ε-amino-protected lysine. Its e-amino free lysine could be conjugated to polyurethane surfaces by reaction of the alpha-amino group with the NHS and deprotection. The covalent conjugation was carried out in phosphate-buffered saline (PBS), pH 8.2. Lysine was used to create a plasminogen-binding potentially fibrinolytic surface[1].
Characteristics
102
-1.6
White powder
1.1313 (rough estimate)
250 °C (dec.)(lit.)
389.3°C (rough estimate)
203.5±27.3 °C
18 ° (C=1, AcOH)
Slightly soluble in water.
2-8°C
17 º (c=1% in acetic acid)
2.53±0.24(Predicted)
2-8°C
Safety Information
NONH for all modes of transport
3
24/25
|Warning|H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
H-Lys(Boc)-OH Use and Manufacturing
Step 1. To a stirred solution of compound 20-1 (5 g, 10.7 mmol) in DCM was added compound 20-2 (5.5 ml, 53 mmol) at r.t. The mixture was stirred at r.t. for 16 h. The reaction mixture was extracted with HL-Lysine monohydrochloride (3.0 g, 16.4 mmol), sodium carbonate (2.09g, 19.7 mmol) and Copper (II) carbonate hydroxide [CuA solution of L-lysine monohydrochloride (20.0 g, 109.5 mmol) and benzotriazole (14.3 g, 120.0 mmol) in a mixture of water (66.6 mL) and THF (111.0 mL) at pH 12 was treated with t-butyl phenyl carbonate (24.3 mL, 131.4 mmol) and stirred 18 hours at 60
It is used as therapy to treat recurrent herpes simplex infections.
Computed Properties
Molecular Weight:246.30
XLogP3:-1.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:246.15795719
Monoisotopic Mass:246.15795719
Topological Polar Surface Area:102
Heavy Atom Count:17
Complexity:261
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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