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H-Lys(Boc)-OH

H-Lys(Boc)-OH structure

CAS No:
2418-95-3
Formula:
C11H22N2O4
Chemical Name:
H-Lys(Boc)-OH
Synonyms:
Lys(Boc)-OH;(S)-2-AMino-6-((tert-butoxycarbonyl)aMino)hexanoic acid;L-Lysine,N6-[(1,1-diMethylethoxy)carbonyl]-;H-Lys(Boc)-OH >=95%;Nε-Boc-L-Lysine≥ 98% (HPLC);Ne-Boc-L-lysine Nε-Boc-L-lysine N-epsilon-tert-Butoxycarbonyl-L-lysine;Nepsilon-Boc-L-lysine H-Lys(Boc)-OH;N6-Boc-L-lysine
Categories:
Biochemical Engineering > Amino Acids and Derivatives

Description

white crystalline powder

H-Lys(Boc)-OH, also known as H-Lys(t-BOC)-OH, is an ε-amino-protected lysine. Its e-amino free lysine could be conjugated to polyurethane surfaces by reaction of the alpha-amino group with the NHS and deprotection. The covalent conjugation was carried out in phosphate-buffered saline (PBS), pH 8.2. Lysine was used to create a plasminogen-binding potentially fibrinolytic surface[1].

H-Lys(Boc)-OH Basic Attributes

Molecular Weight：

246.3

Exact Mass：

246.157959

BRN：

2417626

Color/Form：

White to Almost white

HScode：

29241990

Characteristics

PSA：

102

XLogP3：

-1.6

Appearance：

White powder

Density：

1.1313 (rough estimate)

Melting Point：

250 °C (dec.)(lit.)

Boiling Point：

389.3°C (rough estimate)

Flash Point：

203.5±27.3 °C

Refractive Index：

18 ° (C=1, AcOH)

Water Solubility：

Slightly soluble in water.

Storage Conditions：

2-8°C

Specific rotation：

17 º (c=1% in acetic acid)

PKA：

2.53±0.24(Predicted)

Critical Temperature & Pressure：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

24/25

GHS Classification：

|Warning|H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

Boc-lysine

H-Lys(Boc)-OH Use and Manufacturing

Methods of Manufacturing

Step 1. To a stirred solution of compound 20-1 (5 g, 10.7 mmol) in DCM was added compound 20-2 (5.5 ml, 53 mmol) at r.t. The mixture was stirred at r.t. for 16 h. The reaction mixture was extracted with HL-Lysine monohydrochloride (3.0 g, 16.4 mmol), sodium carbonate (2.09g, 19.7 mmol) and Copper (II) carbonate hydroxide [CuA solution of L-lysine monohydrochloride (20.0 g, 109.5 mmol) and benzotriazole (14.3 g, 120.0 mmol) in a mixture of water (66.6 mL) and THF (111.0 mL) at pH 12 was treated with t-butyl phenyl carbonate (24.3 mL, 131.4 mmol) and stirred 18 hours at 60

Uses

It is used as therapy to treat recurrent herpes simplex infections.

Computed Properties

Molecular Weight:246.30
XLogP3:-1.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:246.15795719
Monoisotopic Mass:246.15795719
Topological Polar Surface Area:102
Heavy Atom Count:17
Complexity:261
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of H-Lys(Boc)-OH

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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