8-HYDROXY-QUINOLINE-5-CARBALDEHYDE
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8-HYDROXY-QUINOLINE-5-CARBALDEHYDE
structure -
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CAS No:
2598-30-3
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Formula:
C10H7NO2
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Chemical Name:
8-HYDROXY-QUINOLINE-5-CARBALDEHYDE
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Synonyms:
5g1pcs;IFLAB-BBF2108-0159;8-HYDROXY-QUINOLINE-5-CARBALDEHYDE;5-Quinolinecarboxaldehyde,8-hydroxy-
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CAS No:
8-HYDROXY-QUINOLINE-5-CARBALDEHYDE Basic Attributes
173.17
173.04800
122131
DTXSID70298275
2933499090
Safety Information
26
Xn
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
H302
8-HYDROXY-QUINOLINE-5-CARBALDEHYDE Use and Manufacturing
8-Hydroxyquinoline (5 g, 0.3 mol) was dissolved in ethanol (50 mL) to which was added sodium hydroxide (10 g, 0.25 mol) dissolved in water (15 mL). The solution was refluxed during which time chloroform was added dropwise over 30 min. After refluxing for 20 h, ethanol and excess chloroform were evaporated in vacuo. The resulting residue was dissolved in 150 mL of water and the solution was made slightly acidic by adding dilute hydrochloric acid. The resulting yellow colored solid was extract with dichloromethane then purified by column chromatography (silica gel, dichloromethane/methanol) to afford the title product as a white solid (115 mg, 0.67 mmol).
Computed Properties
Molecular Weight:173.17
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:173.047678466
Monoisotopic Mass:173.047678466
Topological Polar Surface Area:50.2
Heavy Atom Count:13
Complexity:195
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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8-HYDROXY-QUINOLINE-5-CARBALDEHYDE
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