3-Chlorophenyl isocyanate

clear colourless to slightly yellow liquid

The preparation method is to add toluene into the reaction kettle, pass a certain amount of phosgene under cooling, then add the toluene solution of m-chloroaniline dropwise to the reaction kettle, continue stirring for a certain period of time after the addition, and then transfer the materials. In the hot reaction kettle, continue to pass in phosgene and slowly raise the temperature to a certain temperature. At this time, a large amount of hydrogen chloride and phosgene escape, which are absorbed by toluene after condensation, and continue to pass in phosgene to react until the material is transparent. End. Blow in nitrogen to drive off phosgene and hydrogen chloride, then move the materials to a desolventizing kettle, and desolvate toluene to obtain a finished product.

3-chlorophenyl isocyanate is an intermediate of the herbicide chloramphenicol.

Molecular Weight:153.56
XLogP3:3.4
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:152.9981414
Monoisotopic Mass:152.9981414
Topological Polar Surface Area:29.4
Heavy Atom Count:10
Complexity:154
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes