3,6-Dichloro-4-pyridazinol

Production of 6-chloro-3-(2-cyclopropyl-6-methylphenoxy)-4-pyridazinol To a mixture of 25.5 g (150 mmol) of sodium 2-cyclopropyl-6-methylphenoxide and 12.5 g of t-butanol in an autoclave was added 2.5 g (purity: 99%; 15.0 mmol) of Example 34 Production of 6-chloro-3-phenoxy-4-pyridazinol A mixture of 25.0 g (266 mmol) of phenol and 30.0 g of cyclohexanol was charged, and 25.5 g (266 mmol) of sodium t-butoxide was added to the mixture over one hour, and then stirred at 70 C. for 30 minutes. The resultant solution was cooled to 40 C., and then 8.94 g (purity: 98%; 153.1 mmol) of Example 33 Production of 6-chloro-3-[3-(trifluoromethyl)phenoxy]-4-pyridazinol 3.0 g (purity: 90%; 16.4 mmol) of Example 32 Production of 6-chloro-3-(4-t-butylphenoxy)-4-pyridazinol 3.0 g (purity: 90%; 16.4 mmol) of Example 1Production of 6-chloro-3-(2-cyclopropyl-6-methylphenoxy)-4-pyridazinolTo a mixture of 13.0 g (87.0 mmol) of 2-cyclopropyl-6-methylphenol and 1, 2-dichlorobenzene (78.3 mL) was added 3.67 g (87.0 mmol) of 95% sodium hydroxide at room temperature. The resultant mixture was heated to 180 C. and subjected to azeotropic dehydration under reflux while stirring for 30 minutes. To the resultant solution was added dropwise the preliminarily prepared solution of 5.00 g (purity: 95.7%; 29.0 mmol) of

Molecular Weight:164.97
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:163.9544181
Monoisotopic Mass:163.9544181
Topological Polar Surface Area:41.5
Heavy Atom Count:9
Complexity:209
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes