N-Methyldiethanolamine

119.16

119.16

1734441

203-312-7

3IG3K131QJ

1600

51500|49131|11690

DTXSID8025591

Colorless liquid|Liquid

2922194000

43.7

-1.08

Clear colorless to light yellow Liquid

1.0377 g/cm³ @ Temp: 20 °C

-21 °C

247 °C

260 °F

1.4675-1.4695

Micible with water.

Store below +30°C.

0.01 mm Hg ( 20 °C)

4 (vs air)

0.9-8.4%(V)

Amine-like odor

Henry's Law constant = 3.14X10-11 atm-cu m/mol at 25 °C (est)

pKa = 8.52 (conjugate acid)

Hydroxyl radical reaction rate constant = 9.69X10-11 cu cm/molec-sec at 25 °C (est)

Very water soluble (NTP, 1992).

Alcohols and Polyols

METHYLDIETHANOLAMINE is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. This compound may react with oxidizing materials. (NTP, 1992)

265 °C

The vapour is heavier than air.

418.7 kJ/kg

II

8

2735

1

36

24

KL7525000

Xi

Store in an area without drain or sewer access. Separated from strong acids.

Stable under recommended storage conditions.

P264, P280, P305+P351+P338, P33, P313

H319

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.|Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.|Principles and methods for destruction of chemical weapons: ... "Destruction of chemical weapons" means a process by which chemicals are converted in an essentially irreversible way to a form unsuitable for production of chemical weapons, and which in an irreversible manner renders munitions and other devices unusable as such. ... Each ... /nation/ shall determine how it shall destroy chemical weapons, except that the following processes may not be used: dumping in any body of water, land burial or open-pit burning. It shall destroy chemical weapons only at specifically designated and appropriately designed and equipped facilities. ... Each ... /nation/ shall ensure that its chemical weapons destruction facilities are constructed and operated in a manner to ensure the destruction of the chemical weapons; and that the destruction process can be verified under the provisions of this Convention.

Incompatible materials: Oxidizing agents. Do not store near acids.

Organization for the Prohibition of Chemical Weapons; Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and Their Destruction. The Chemical Weapons Convention (CWC) is an international treaty which bans the development, production, stockpiling, and transfer or use of chemical weapons. The Convention mandates the destruction and prohibition of chemical weapons and related facilities and provides for restrictions on international trade in toxic chemicals and precursors.[Available from, as of November 12, 2008: http://www.opcw.org]

Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as nitrogen oxides and carbon monoxide, may be formed when involved in fire. (USCG, 1999)|Combustible.

|Warning|H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P280, P305+P351+P338, and P337+P313|H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|Aggregated GHS information provided by 1469 companies from 5 notifications to the ECHA C&L Inventory.|H320: Causes eye irritation [Warning Serious eye damage/eye irritation]|P201, P202, P264, P281, P305+P351+P338, P308+P313, P337+P313, P405, and P501

SMALL SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and keep it away from oxidizing materials. (NTP, 1992)

Full impervious protective clothing, including boots and gloves. Where splashing is possible wear full face shield or chemical safety goggles. Use approved respirator to protect against vapors. (USCG, 1999)|Eye/face protection: Safety glasses with side-shields conforming to EN 166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).|Handle with gloves.|Body Protection: Impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.|Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Explosive limits , vol% in air: 0.9-8.4

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.|Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Environmental precautions: Do not let product enter drains. Methods and materials for containment and cleaning up: Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Environmental precautions: Do not let product enter drains.|Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist.|Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.|Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.|SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

A skin and eye irritant.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Store in an area without drain or sewer access. Separated from strong acids.

Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying.

The substance is irritating to the eyes and skin.

NO open flames.

Use ventilation, local exhaust or breathing protection.

Protective gloves.

Wear safety goggles.

| 1 - Materials that, under emergency conditions, can cause significant irritation.| 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.| 0 - Materials that in themselves are normally stable, even under fire conditions.

IDENTIFICATION AND USE: N-Methyldiethanolamine (MDEA) is a colorless liquid. MDEA is used as an intermediate, in absorption of acidic gases, as a catalyst for polyurethane foams, and pH control agent. HUMAN STUDIES: There are no data available. ANIMAL STUDIES: MDEA was irritating to the guinea pig skin, and showed potential to induce allergic contact dermatitis. MDEA caused slight eye irritation. In rats, recurrent skin application of MDEA produced a dose-related irritant effect, but there was no evidence for systemic cumulative or specific target organ or tissue toxicity. Rat dams showed dose-dependent skin irritation following repeated cutaneous application of MDEA during pregnancy. In addition, maternal toxicity was also present as anemia in dams receiving 1000 mg/kg/day. Despite maternal toxicity, there was no evidence of developmental effects. MDEA was not genotoxic when tested in the Salmonella/microsome reverse gene mutation test, the CHO/HGPRT forward gene mutation test, a sister chromatid exchange test in cultured CHO cells, and an in vivo peripheral blood micronucleus test in mice.

LD50 Rabbit (male) percutaneous 9.85 mL/kg|LD50 Rabbit (female) percutaneous 10.9 mL/kg|LD50 Mouse ip 500 mg/kg|LD50 Rat oral 4780 mg/kg

N-Methyldiethanolamine's production and use in the absorption of acidic gases, catalyst for polyurethane foams, pH control agent(1) and surfactant intermediate(2) may result in its release to the environment through various waste streams(SRC). Its use as an agent precursor(3) and possible chemical warefare agent(4) will result in its direct release to the environment(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that N-methyldiethanolamine is expected to have very high mobility in soil(SRC). The pKa of N-methyldiethanolamine is 8.52(3), indicating that this compound will exist partially in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of the cation from moist soil is not expected because cations do not volatilize(SRC). Volatilization of neutral N-methyldiethanolamine from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.1X10-11 atm-cu m/mole(SRC) based upon its vapor pressure, 2.0X10-4 mm Hg(5), and assigned value for water solubility of 1X10+6 mg/L (miscible)(6). N-Methyldiethanolamine is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(5). N-Methyldiethanolamine did not biodegrade after 28 days in activated sludge, but degraded >96% after 40 days in a continuous-flow experiment where the inoculum had time to acclimate(7). These data indicate that biodegradation of N-methyldiethanolamine in soil may only be important under acclimated conditions(7).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that N-methyldiethanolamine is not expected to adsorb to suspended solids and sediment(SRC). A pKa of 8.52(3) indicates N-methyldiethanolamine will exist partially in the cation form at pH values of 5 to 9 and, therefore, volatilization of the cation from water surfaces is not expected to be an important fate process(SRC). Volatilization of neutral N-methyldiethanolamine from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 3.1X10-11 atm-cu m/mole(SRC) derived from its vapor pressure, 2.0X10-4 mm Hg(5), and assigned value for water solubility of 1X10+6 mg/L (miscible)(6). N-Methyldiethanolamine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(4). According to a classification scheme(7), an estimated BCF of 3(SRC), from an estimated log Kow of -1.50(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low. N-Methyldiethanolamine did not biodegrade after 28 days in activated sludge, but degraded >96% after 40 days in a continuous-flow experiment where the inoculum had time to acclimate(8). These data indicate that biodegradation of N-methyldiethanolamine in water may only occur under acclimated conditions(8). [|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), N-methyldiethanolamine, which has a vapor pressure of 2.0X10-4 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase N-methyldiethanolamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4 hours(SRC), calculated from its rate constant of 9.7X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). N-Methyldiethanolamine does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of N-methyldiethanolamine with photochemically-produced hydroxyl radicals has been estimated as 9.7X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 4 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). N-Methyldiethanolamine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). N-Methyldiethanolamine does not contain chromophores that absorb at wavelengths >290 nm(2) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 3 was calculated in fish for N-methyldiethanolamine(SRC), using an estimated log Kow of -1.50(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low.

Using a structure estimation method based on molecular connectivity indices(1), the Koc of N-methyldiethanolamine can be estimated to be 1(SRC). According to a classification scheme(2), this estimated Koc value suggests that N-methyldiethanolamine is expected to have very high mobility in soil. The pKa of N-methyldiethanolamine is 8.52(3), indicating that this compound will exist partially in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).

A pKa of 8.52(1) indicates N-methyldiethanolamine will exist partially in the cation form at pH values of 5 to 9 and, therefore, volatilization from water surfaces of the cation is not expected to be an important fate process(SRC). The Henry's Law constant for neutral N-methyldiethanolamine is estimated as 3.1X10-11 atm-cu m/mole(SRC) derived from its vapor pressure, 2.0X10-4 mm Hg(2), and assigned value for water solubility of 1X10+6 mg/L (miscible)(3). This Henry's Law constant indicates that N-methyldiethanolamine is expected to be essentially nonvolatile from water and moist soil surfaces(4). N-Methyldiethanolamine is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(2).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 6811 workers (1031 of these are female) were potentially exposed to N-methyldiethanolamine in the US(1). Occupational exposure to N-methyldiethanolamine may occur through dermal contact with this compound at workplaces where N-methyldiethanolamine is produced or used(SRC). Use data indicate that the general population is not likely to be exposed to N-methyldiethanolamine unless released towards people as a chemical warfare agent.(SRC).

A study was conducted examining the pharmacokinetics and tissue distribution of N-methyldiethanolamine (MDEA) following intravenous (iv) or cutaneous exposure in the rat. The metabolic fate and disposition of MDEA was assessed following infusion of 50 or 500 mg/kg of radiolabeled MDEA into the jugular veins of Fischer-344-rats or following application of 500 mg/kg to the shaved skin. MDEA was rapidly metabolized following iv administration with only 9% and 44% of the total radioactivity remaining in the plasma as unchanged MDEA 1 hour after dosing with 50 and 500 mg/kg, respectively. The pharmacokinetics at the higher dose appeared to be nonlinear. Plasma radioactivity increased slowly following cutaneous exposure and continued to be available after the chemical was washed off of the skin. Up to 50% of the applied dose was absorbed after 72 hours of skin contact. Up to 24% and 36% of the respective iv and cutaneously administered doses remained in the carcass 72 hours after dosing. The liver and the kidneys contained the highest levels of radioactivity. The principal route of elimination after both methods of exposure was urinary; the elimination half life following cutaneous dosing was more than 30 hours. The major urinary component 72 hours after iv dosing with 500 mg/kg was the parent compound, whereas following cutaneous dosing and iv dosing with 50 mg/kg, the major urinary component was metabolites. The authors conclude that MDEA is easily absorbed from the skin, and that metabolic processes play an important role in the elimination of this compound.

... The elimination half life following cutaneous dosing /in rats/ was more than 30 hours.

Exposure can cause irritation of eyes, nose and throat. (USCG, 1999)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Fresh air, rest.

Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/Amines and related compounds/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/Amines and related compounds/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen ... . Treat seizures with diazepam (Valuim) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/Amines and related compounds/

2,2'-(methylimino)diethanol

The substance can be absorbed into the body by ingestion.

Cough. Nausea. Sore throat.

Redness. Pain.

Redness. Pain.

Grade: Technical.

Adhesive manufacturing|Ethanol, 2,2'-(methylimino)bis-: ACTIVE|/The Chemical Weapons Convention (CWC) is an international treaty which bans the development, production, stockpiling, and transfer or use of chemical weapons. The Convention mandates the destruction and prohibition of chemical weapons and related facilities and provides for restrictions on international trade in toxic chemicals and precursors./ The Convention's monitoring and verification measures involve submission of declarations regarding ... /Schedule 1, 2, and 3 chemicals/ and inspections by the Organization for the Prohibition of Chemical Weapons of the facilities where these chemicals are produced. ... Schedule 3 chemicals ... /may/ have been stockpiled or used as weapons, but ... are produced /and used/ in large quantities for purposes not prohibited by the Convention (2). Methyldiethanolamine is listed in the CWC Annex on Chemicals under Schedule 3 (1).

Method: EPA-RCA 8321B; Procedure: high-performance liquid chromatography, coupled with both thermospray-mass spectrometry and an ultraviolet detector; Analyte: N-methyldiethanolamine; Matrix: various; Detection Limit: not provided.|... Alkanolamines are analyzed by gas chromatography or wet test methods. /Alkanolamines/