2,3-Dimethylanisole

clear light yellow liquid

1) 2, 3-dimethylphenol is dissolved in an equimolar 15percent aqueous solution of sodium hydroxide and added at twice the molar amount at 10-20°C.Dimethyl sulphate was added dropwise, warmed up to 50°C, and kept warm for 2 hours. The mixture was allowed to stand for stratification, and the upper ether layer was taken and washed with a little dilute alkali.This time, 2, 3-dimethylanisole was obtained in a yield of 95percent.KGeneral procedure: General procedure for the alkylation of phenols with dimethyl carbonate. A 17-mL stainless steel high-pressure micro reactor was charged with 3 mmol of Mn2(CO)10, W(CO)6, or Co2(CO)8, 100 mmol of the corresponding phenol, and 300 mmol of dimethyl carbonate, and the reactor was hermetically closed and heated for 1 h at 180°C. The reactor was then cooled to room temperature and opened, and the mixture was filtered through a layer of alumina. Unreacted dimethyl carbonate was distilled off, and the residue was distilled under atmospheric or reduced pressure or recrystallized from ethanol. 1-Methoxy-2, 3-dimethylbenzene. Yield 99percent, bp 95.8–96°C (30 mm). 13C NMR spectrum, δC, ppm: 11.99 (CH3), 20.56 (CH3), 55.83 (OCH3), 110.02 (C6), 122.43 (C4), 124.78 (C2), 128.74 (C5), 137.70 (C3), 157.36 (C1). Found, percent: C 79.29; H 8.82. C9H12O. Calculated, percent: C 79.37percent; H 8.88.

Molecular Weight:136.19
XLogP3:2.5
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:136.088815002
Monoisotopic Mass:136.088815002
Topological Polar Surface Area:9.2
Heavy Atom Count:10
Complexity:101
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes