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Formocortal

Formocortal structure

CAS No:
2825-60-7
Formula:
C29H38ClFO8
Chemical Name:
Formocortal
Synonyms:
Pregna-3,5-diene-6-carboxaldehyde,21-(acetyloxy)-3-(2-chloroethoxy)-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-20-oxo-,(11β,16α)-;Pregna-3,5-diene-6-carboxaldehyde,3-(2-chloroethoxy)-9-fluoro-11β,16α,17,21-tetrahydroxy-20-oxo-,cyclic 16,17-acetal with acetone,21-acetate;3H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole,pregna-3,5-diene-6-carboxaldehyde deriv.;(11β,16α)-21-(Acetyloxy)-3-(2-chloroethoxy)-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-20-oxopregna-3,5-diene-6-carboxaldehyde;3-(2-Chloroethoxy)-9-fluoro-11β,16α,17,21-tetrahydroxy-20-oxo-3,5-pregnadiene-6-carboxaldehyde cyclic 16,17-acetal with acetone 21-acetate;Formocortal;Fluoroformylon;3-(2′-Chloroethoxy)-6-formyl-9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-3,5-diene-20-one 16,17-acetonide,21-acetate;Fluoroformylone;Deflamene;3-(2-Chloroethoxy)-6-formyl-9α-fluoropregna-3,5-diene-11β,16α,17,21-tetrol-20-one 21-acetate 16α,17α-acetonide;3-(2-Chloroethoxy)-9α-fluoro-6-formyl-11β,21-dihydroxy-16α,17α-isopropylidenedioxypregna-3,5-dien-20-one;FI 6341;Fluderma;Cortocin F;Cutisterol;Deflamin;Dermacort;Fluoformylon;NSC 150527
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

Formocortal is a steroid. It derives from a hydride of a pregnane.

Formocortal Basic Attributes

Molecular Weight：

569.063

Exact Mass：

569.06

EC Number：

220-584-2

UNII：

8E21R0Z4M5

NSC Number：

150527

ATC Code：

S - Sensory organs

Characteristics

PSA：

108

XLogP3：

3.96280

Density：

1.33g/cm3

Melting Point：

181 °C

Boiling Point：

683.7ºC at 760mmHg

Flash Point：

367.3ºC

Refractive Index：

1.564

Toxicity：

LD50 in mice: >2000 mg/kg orally; 490 mg/kg s.c.; 537 mg/kg i.p. (Bertazzoli)

Formocortal Use and Manufacturing

formocortal is a corticosteroid with antiinflammatory activity used in ophthalmology.

Computed Properties

Molecular Weight:569.1
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:8
Exact Mass:568.2239240
Monoisotopic Mass:568.2239240
Topological Polar Surface Area:108
Heavy Atom Count:39
Complexity:1150
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes