Ethyl 2-(dimethoxyphosphinyl)acetate

The dry and clean 500mL coil was heated to 150 degree celcius , take the compound 1 (standard atmospheric pressure boiling point of 142 ~145 ° C) 1000 g (0.7 eq. 8.16 mol) was placed in a shot bottle A, Add 4000g toluene dilution, take trimethyl phosphite (standard Atmospheric pressure at the boiling point of 112 ° C) 1417g (1.0eq.11.42mol) placed in the bottle B, adding 3583g toluene diluted until The coil was started at a stable temperature and pump A (compound 1 in toluene): 25.0 g / min, pump B (trimethyl phosphite):25.0 g / min. Residence time 10min, the reaction pressure is 0.5 ~ 2.0Mpa. The discharge port is directly connected to the thin film evaporation device, control The pressure of 4 ~ 10 × 102Pa, temperature 95 ~ 105 , the final product Compound 3 (boiling point 110 ~ 112 , 466Pa) 1344 g, yield 84percent.

Molecular Weight:196.14
XLogP3:-0.2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:196.05006051
Monoisotopic Mass:196.05006051
Topological Polar Surface Area:61.8
Heavy Atom Count:12
Complexity:182
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes