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D-Serine

D-Serine structure

CAS No:
312-84-5
Formula:
C3H7NO3
Chemical Name:
D-Serine
Synonyms:
D-Serine;Serine,D-;(R)-Serine;NSC 77689;(R)-2-Amino-3-hydroxypropanoic acid;(2R)-2-Amino-3-hydroxypropanoic acid
Categories:
Pharmaceutical Intermediates > Blood Glucose Regulators

Description

(R)-Serine is a non-essential amino acid involved in the biosynthesis of amino acids.

Solid

D-serine is the R-enantiomer of serine. It has a role as a NMDA receptor agonist, a human metabolite and an Escherichia coli metabolite. It is a D-alpha-amino acid and a serine. It is a conjugate base of a D-serinium. It is a conjugate acid of a D-serinate. It is an enantiomer of a L-serine. It is a tautomer of a D-serine zwitterion.|D-Serine is a non-essential amino acid and dextro isomer of serine with antipsychotic activity. D-serine is a selective full agonist at the glycine site of N-methyl-D-aspartate (NMDA)-type glutamate receptor. Hypofunction of NMDA type of neurotransmission is believed to play a major role in pathophysiology of schizophrenia, therefore, administration of D-serine and subsequent activation of NMDA receptors may alleviate psychotic tendencies.

D-Serine Basic Attributes

Molecular Weight：

105.09300

Exact Mass：

105.09

EC Number：

206-229-4

UNII：

1K77H2Z9B1

DSSTox ID：

DTXSID9041021

NCI Thesaurus Code：

C61739

HScode：

2922509090

Characteristics

PSA：

83.55000

XLogP3：

-3.1

Appearance：

Solid

Density：

1.415g/cm3

Melting Point：

229 °C (decomp)

Boiling Point：

394.8ºC at 760mmHg

Flash Point：

192.6ºC

Refractive Index：

1.519

Water Solubility：

H2O: 346 g/L (20 ºC)

Storage Conditions：

Store at RT.

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R36/37/38

safety instructions：

S24/25

RTECS Number：

VT8200000

Marks：

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

D-Serine Use and Manufacturing

Uses

A proteinogenic amino acids involved in the biosynthesis of purines and pyrimidines. Inhibitor of serine palmitoyltransferase. A neuromodulator.

Manufacturing Info：

D-Serine: ACTIVE

Computed Properties

Molecular Weight:105.09
XLogP3:-3.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:105.042593085
Monoisotopic Mass:105.042593085
Topological Polar Surface Area:83.6
Heavy Atom Count:7
Complexity:72.6
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Methyl phenylacetate

Formaldehyde

Glycine

Hydrochloric acid

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