Berberine, sulfate

768.79

768.19900

206-258-2

FST3E667FF

YELLOW CRYSTALS

29399990

170

5.93540

Yellow powder with an orange cast

H2O: almost transparency

Subcutaneous-mouse LD50: 13.2 mg/kg; peritoneal-mouse LD50: 26.4 mg/kg

Flammable; burning produces toxic nitrogen oxides and sulfur oxide fumes

RED-YELLOW NEEDLES /TRIHYDRATE/|YELLOW NEEDLES /TRIHYDRATE/|SOLUBLE IN ABOUT 30 PARTS WATER, IN ALC /TRIHYDRATE/

Ⅲ

6.1(b)

1544

6.1

DR9867300

Low temperature, low ventilation and low dryness; store it separately from the food materials in the warehouse

highly toxic

LD50 RATS ORAL MORE THAN 1 G/KG|LD50 RATS INTRAPERITONEAL 88.5 MG/KG|LD50 RATS INTRAMUSCULAR 14.5 MG/KG

SHOULD NOT BE HANDLED EXCESSIVELY, SINCE IT MAY BE ABSORBED THROUGH THE SKIN AND HAVE TOXIC EFFECT UPON THE BODY. /BERBERINE/

EXPTL USE (VET): ORALLY ADMIN BERBERINE SULFATE (350-700 MG/KG) WAS EFFECTIVE IN TREATING CANDIDA ALBICANS INFECTIONS OF THE INTESTINE IN MICE.|EXPTL USE: DILATION OF HUMAN EYE PUPILS, TOPICAL ANESTHESIA &/OR FLUORESCENT STAINING OF CORNEAL EPITHELIAL DEFECTS &/OR FLUORESCENCE IN APPLANATION TONOMETRY, IS ACCOMPLISHED BY TOPICAL APPLICATION OF OPHTHALMIC SOLN OF HYDRASTIS COMPD SUCH AS BERBERINE.|/PRC: FORMER USES/ BITTER STOMACHIC; ANTIBACTERIAL; ANTIMALARIAL; ANTIPYRETIC /BERBERINE/|MILD LOCAL ANESTHETIC ON MUCOUS MEMBRANE. /BERBERINE/

...MAY BE ABSORBED THROUGH THE SKIN... /BERBERINE/

TOXIC DOSES DEPRESS HEART (DIRECTLY & REFLEXLY THROUGH THE VAGUS), RELAX BLOOD VESSELS, DEPRESS RESPIRATIONS, & STIMULATE SMOOTH MUSCLE IN INTESTINES, BRONCHI, & POSSIBLY UTERUS. /BERBERINE/|AN ALKALOID POISON. IN TOXIC DOSES IT LOWERS TEMPERATURE, INCREASES PERISTALSIS, AND CAUSES DEATH BY CENTRAL PARALYSIS. /BERBERINE/|TOXIC BY INGESTION, INHALATION, AND SKIN ABSORPTION. /BERBERINE/

/BERBERINE IS/ ALKALOID, USUALLY AS SULFATE; OBTAINED FROM RHIZOMES AND ROOTS OF HYDRASTIS CANADENSIS.|/BERBERINE/...BEHAVES AS A QUATERNARY BASE, FORMING SALTS BY REPLACEMENT OF THE OH GROUP: PERKIN, JR, J CHEM SOC 113, 503 (1918). /BERBERINE/

MICROCHEMICAL TESTS FOR ALKALOIDS AND RELATED AMINES...REAGENT: HYDROCHLORIC ACID. /BERBERINE/|BERBERINE SULFATE IN 95% ETHANOL WAS SUBJECTED TO THIN LAYER CHROMATOGRAPHY.