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Allopurinol

Allopurinol structure

CAS No:
315-30-0
Formula:
C5H4N4O
Chemical Name:
Allopurinol
Synonyms:
4H-Pyrazolo[3,4-d]pyrimidin-4-one,1,5-dihydro-;1,5-Dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one;BW 56-158;Allopurinol;HPP;Zyloprim;Zyloric;4-Hydroxypyrazolo[3,4-d]pyrimidine;Allopurinol(I);Milurit;1H-Pyrazolo[3,4-d]pyrimidin-4-ol;4-Hydroxy-1H-pyrazolo[3,4-d]pyrimidine;Bloxanth;Foligan;Epidropal;Uricemil;Urosin;Allopur;Uriprim;Atisuril;Gotax;Gichtex;4-Oxopyrazolo[3,4-d]pyrimidine;Sllo-puren;Cellidrin;Cosuric;Caplenal;Ketanrift;Monarch;BW 15658;Riball;Anoprolin;Alositol;Urtias;NSC 1390;Bleminol;Ketobun A;Suspendol;Hexanurat;Uripurinol;Takanarumin;Lysuron;Urobenyl;Nektrohan;Urbol;Allurtal;Xanturat;Geapur;Lopurin;Dabroson;Anzief;Miniplanor;Apurol;Sigapurol;Apurin;Remid;Allozym;Hamarin;Aloral;Ledopur;Embarin;Adenock;Apulonga;NSC 101655;1,5-Dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one;Aloprim;Alopurinol;1H,4H,7H-Pyrazolo[3,4-d]pyrimidin-4-one;1H,4H,5H-Pyrazolo[3,4-d]pyrimidin-4-one;1H-Pyrazolo[3,4-d]pyrimidin-4(5H)-one;22767-92-6;39464-14-7;184856-42-6
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

Allopurinol (Zyloprim) is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.Target: XAOAllopurinol (Zyloprim, and generics) is a drug used primarily to treat hyperuricemia (excess uric acid in blood plasma) and its complications, including chronic gout. It is a xanthine oxidase inhibitor which is administered orally. A common misconception is that allopurinol is metabolized by its target, xanthine oxidase, but this action is principally carried out by Aldehyde oxidase. The active

Allopurinol Basic Attributes

Molecular Weight：

136.11100

Exact Mass：

136.11

EC Number：

206-250-9

HScode：

2933990090

Characteristics

PSA：

74.43000

XLogP3：

-0.5

Appearance：

4-hydroxypyrazolo(3,4-d)pyrimidine is an odorless tasteless white microcrystalline powder. (NTP, 1992)

Density：

1.89g/cm3

Melting Point：

>350 °C

Boiling Point：

290.8ºC at 760 mmHg

Flash Point：

129.7ºC

Refractive Index：

1.816

Water Solubility：

H2O: 0.35 g/L (25 ºC)

Storage Conditions：

Store in a tightly closed container. Store in a cool, dry area away from incompatible substances.

Vapor Pressure：

1.17X10-8 mm Hg at 25 deg C (est)

Toxicity：

LD50 oral in mouse: 78mg/kg

Odor：

SLIGHT

Taste：

TASTELESS

PKA：

10.2(at 25℃)

Safety Information

Packing level：

III

Hazard category：

6.1

Transport codes：

UN 2811

wgk germany：

hazard class code：

R25; R36/37/38; R43

safety instructions：

S24-S26-S36/37/39-S45

RTECS Number：

UR0785000

Marks：

Stability/Shelf Life：

Stable in light and air

Precautionary statement(s)：

Missing Phrase - N15.00950417-P280

Hazard Statements：

H301-H317

Allopurinol Use and Manufacturing

1. Xanthine oxidase inhibitor; decreases uric acid production. Used in treatment of hyperuricemia and chronic gout. Antiurolithic
2. Antihyperuricemia, antigout, antiurolithic

Computed Properties

Molecular Weight:136.11
XLogP3:-0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Exact Mass:136.03851076
Monoisotopic Mass:136.03851076
Topological Polar Surface Area:70.1
Heavy Atom Count:10
Complexity:190
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Ethyl cyanoacetate

Drug Function and Efficacy

Inhibit uric acid synthesis, prevent hypoxanthine and xanthine from being metabolized into uric acid by inhibiting xanthine oxidase, reduce uric acid production, lower uric acid levels in blood and urine, prevent uric acid crystal deposition, and help redissolve uric acid crystals in the tissues of gout patients.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Allopurinol Tablets
Ingredients	The main ingredient of this product is allopurinol. Its chemical name is 1H-pyrazolo[3,4-d]pyrimidine-4-ol. Molecular formula: C5H4N4O Molecular weight: 136.11
Indication	1. Drinking alcohol, chlorthalidone, ethacrynic acid, furosemide, metolazone, pyrazinamide or thiazide diuretics can increase the uric acid content in serum. When using this product to control gout and hyperuricemia, attention should be paid to the adjustment of the dosage. For patients with hypertension or poor renal function, there are reports of renal failure and allergies when this product is used together with thiazide diuretics; 2. When this product is used together with ampicillin, the incidence of rash increases, especially in patients with hyperuricemia; 3. When this product is used together with anticoagulants such as dicoumarol and indandione derivatives, the effect of anticoagulants can be enhanced, and attention should be paid to adjusting the dosage; 4. When this product is used together with azathioprine or mercaptopurine, the latter's dosage should generally be reduced by 1/4 to 1/3; 5. When this product is used together with cyclophosphamide, the suppression of bone marrow can be more obvious; 6. When this product is used together with uricosuric drugs, the possibility of kidney stone formation can be increased.
Specifications	0.1g
Manufacturer	Han Hui Pharmaceuticals Company Limited

Allopurinol
Ingredients	The main ingredient of this product is allopurinol, whose chemical name is 1H-pyrazolo[3,4-d]pyrimidine-4-ol.
Indication	1 Drinking alcohol, diuretics such as chlorthalidone, uric acid, furosemide, pyrazinamide and thiazide can increase serum uric acid concentration. When this product is used with these drugs, it is necessary to adjust the dosage to control hyperuricemia. 2 When used with aspirin or other salicylates, the uric acid excretion effect of this product can be inhibited. 3 When used with indomethacin, dapsone, naproxen, etc., the blood concentration of the latter increases, and the toxicity is increased. 4 When used with various penicillins and cephalosporins, the blood concentration of the latter increases and lasts for a long time, and the toxicity is increased, especially the toxicity to the kidneys. 5 When used with oral hypoglycemic drugs, the effect of the latter is enhanced.
Manufacturer	Wuxi Taxus Pharmaceutical Co., Ltd.

Allopurinol Tablets
Ingredients	The main ingredient of this product is allopurinol, whose chemical name is 1H-pyrazolo[3,4-d]pyrimidine-4-ol.
Indication	1 Drinking alcohol, diuretics such as chlorthalidone, uric acid, furosemide, pyrazinamide and thiazide can increase serum uric acid concentration. When this product is used with these drugs, it is necessary to adjust the dosage to control hyperuricemia. 2 When used with aspirin or other salicylates, the uric acid excretion effect of this product can be inhibited. 3 When used with indomethacin, dapsone, naproxen, etc., the blood concentration of the latter increases, and the toxicity is increased. 4 When used with various penicillins and cephalosporins, the blood concentration of the latter increases and lasts for a long time, and the toxicity is increased, especially the toxicity to the kidneys. 5 When used with oral hypoglycemic drugs, the effect of the latter is enhanced.
Specifications	0.1g*100s
Manufacturer	Matrix Laboratories (Xiamen) Ltd.

See More Related Drugs

Registered Holders

INDOCO REMEDIES LTD

United States
Active
MATRIX PHARMACORP PRIVATE LTD

United States
Active
SIGNA SA DE CV

United States
Active

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