4-AMINOMETHYL-BENZAMIDEHYDROCHLORIDE

Ethyl 2-(2-fluoro-4-(2, 2, 2-trifluoroethyl)phenoxy)-4-formylnicotinate (0.15 g) obtained in Reference Example 326 was dissolved in methanol (3 mL), Ethyl 2-(2-fluoro-4-propylphenoxy)-4-formylnicotinate (0.13 g) obtained in Reference Example 319 was dissolved in methanol (3 mL), Ethyl 2-(4-cyclopropyl-2-fluorophenoxy)-4-formylnicotinate (0.13 g) obtained in Reference Example 317 was dissolved in methanol (3 mL), Ethyl 2-(4-ethyl-2-fluorophenoxy)-4-formylnicotinate (0.13 g) obtained in Reference Example 313 was dissolved in methanol (3 mL), To a solution of ethyl 2-(bromomethyl)-6-(2-fluoro-4-(trifluoromethyl)phenoxy)benzoate (0.21 g) obtained in Reference Example 328 in ethanol (2 mL) were added Example A85 Preparation of (2S, 3Z)-5-{[(2R, 3R, 5S, 6S)-6-{(2E, 4E)-5-[(3R, 4R, 5R, 7S)-7-{2-[(4- carbamoylbenzyl)amino]-2-oxoethyl}-4-hydroxy-l, 6-dioxaspiro[2.5]oct-5-yl]-3-methylpenta-2, 4- dien-l-yl}-2, 5-dimethyltetrahydro-2H-pyran-3-yl]amino}-5-oxopent-3-en-2-yl acetate (B266). Step 1. Synthesis of (2S, 32)-5- {[(2R, 3R, 5S, 6S)-6- {(2£', 4£')-5-[(3R, 4R, 5R, 7S)-7-{2-[(4- carbamoylbenzyl)amino]-2-oxoethyl}-4-hydroxy-l, 6-dioxaspiro[2.5]oct-5-yl]-3-methylpenta-2, 4-dien- l-yl} -2, 5-dimethyltetrahydro-2H-pyran-3-yl]amino} -5-oxopent-3-en-2-yl acetate (B266). To a solution of B1 (18.7 mg, 0.03 mmol, 1 eq.) in NN-dimethylformamide (0.5 mL) at rt was added NN- diisopropylethylamine (21.2 L, 0.12 mmol, 2 eq.) and

Molecular Weight:186.64
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:186.0559907
Monoisotopic Mass:186.0559907
Topological Polar Surface Area:69.1
Heavy Atom Count:12
Complexity:139
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes