4,5-DIMETHOXY-ISATOICANHYDRIDE

6, 7-dimethoxy-2H-3, 1-benzoxazine-2, 4(1H)-dione, 13a; 2-amino-4, 5-dimethoxybenzoic acid (25 g, 0.13 mole) was added to THF (400 ml), then benzyl chloroformate (54 ml, 0.38 mole) was added with very vigorous stirring. The mixture was refluxed overnight, evaporated to dryness and the residue was vacuum evaporated. Ether (425 ml) was poured on the residue, PBr3 (11.88 ml, 0.13 mole) was added and the mixture was refluxed for 48 h. The reaction mixture was filtered and washed with 3.x.150 ml of ether. The residue was taken up in ether and stirred for 1 h, then filtered, washed and dried. The reaction produced 27 g of the above product in the form of a white powder. Yield: 96percent. 10.0 g (50.7 mmol) 2-Amino-4, 5-dimethoxy-benzoic acid were dissolved in 150 ml tetrahydofuran. 6.52 g (22.0 mmol) triphosgene were added and the solution was boiled for 3 h. After equilibration to room temperature the reaction mixture was poured on a water/ice mixture. The residue was filtrated and rinsed with methanol. Yield: 8.7 g=86percent Grey powder

Molecular Weight:223.18
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:223.04807239
Monoisotopic Mass:223.04807239
Topological Polar Surface Area:73.9
Heavy Atom Count:16
Complexity:306
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes