1-(2-Phenylethyl)piperidine
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1-(2-Phenylethyl)piperidine
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CAS No:
332-14-9
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Formula:
C13H19N
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Chemical Name:
1-(2-Phenylethyl)piperidine
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Synonyms:
Piperidine,1-(2-phenylethyl)-;Piperidine,1-phenethyl-;1-(2-Phenylethyl)piperidine;FMP 199;1-Phenethylpiperidine;N-(2-Phenylethyl)piperidine;NSC 122975;AC 927
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CAS No:
Description
AC927 or 1-(2-phenylethyl)piperidine is a selective sigma receptor antagonist, with reported binding affinity of Ki = 30 ± 2 nM for the sigma-1 receptor and Ki = 138 ± 18 nM for the sigma-2 receptor, and negligible binding affinity for other major central nervous system receptors, transporters, and ion channels.
Characteristics
3.2
3.27
0.9542 g/cm3 @ Temp: 20 °C
190-192 °C @ Solvent: Ethanol
162 °C @ Press: 35 Torr
108.5±15.6 °C
1.530
LD50 scu-mus: 150 mg/kg ARZNAD 15,126,65
Toxicity
| Name | Type of Test | Exposure Route | Species Observed | Dose/Duration | Toxic Effects | Reference |
|---|---|---|---|---|---|---|
| ACUTE TOXICITY DATA | LD50 - Lethal dose, 50 percent kill | Subcutaneous | Rodent - mouse | 150 mg/kg | Behavioral--convulsions or effect on seizure threshold Lungs, Thorax, or Respiration--dyspnea |
Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 15,126,1965 |
Computed Properties
Molecular Weight:189.30
XLogP3:3.1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:189.151749610
Monoisotopic Mass:189.151749610
Topological Polar Surface Area:3.2
Heavy Atom Count:14
Complexity:143
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes